Gastrodin derivatives, their preparation methods, their applications and pharmaceutical preparations

Abstract

The invention provides a gastrodin derivative and a preparation method thereof. The gastrodin derivative contains substituted indene ring. The invention also provides a preparation method of the gastrodin derivative. A turbidimetry is used for determining a platelet aggregation rate so as to evaluate an inhibition rate of the gastrodin derivative for the platelet aggregation. An experiment result shows that the gastrodin derivative has an obvious anticoagulation effect and can be used as a potential lead compound in preparing drugs for treating thrombus, cardiovascular and cerebrovascular diseases, stroke and other diseases associated with blood coagulation.

Description

technical field

[0001] The invention relates to the technical field of gastrodin, in particular to gastrodin derivatives, their preparation methods, their applications and pharmaceutical preparations. Background technique

[0002] Cardiovascular and cerebrovascular diseases are a common disease that seriously threatens human beings, especially the health of middle-aged and elderly people. The number of people who die from cardiovascular and cerebrovascular diseases in the world is as high as 15 million every year, ranking first among various causes of death. At present, there are more than 270 million patients with cardiovascular and cerebrovascular diseases in my country, and nearly 3 million people die from cardiovascular and cerebrovascular diseases in China every year, accounting for 51% of the total annual death causes in my country. Cardiovascular and cerebrovascular diseases have become the number one killer with the highest cause of death for human beings, and they a...

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