131results about How to "Reduce and avoid" patented technology

Microparticles and a method for their production is described. The process of the present invention provides a simple, quick, and efficient one-pot process for the production of microparticles containing a non-water soluble active agent. The microparticles are preferably used for pharmaceutical applications and comprise at least 80 wt % microspheres.

A turbulator for a heat exchanger tube, and a method of manufacturing the heat exchanger tube. The turbulator comprises a mesh, ideally a woven mesh, of material, ideally metallic wires. The mesh is formed into corrugations of a size substantially to fill the heat exchanger tube. The method comprises the steps of: making a mesh of material; forming the mesh into corrugations; and fitting the corrugated mesh into the heat exchanger tube so that the corrugated mesh substantially fills the heat exchanger tube for some or all of its length. The turbulator and method are particularly suited to flat heat exchanger tubes.

A medical, electrically powered thermal cover for fitting predominantly the trunk and head of a person experiencing or potentially experiencing traumatic or cold-exposure hypothermia. The thermal cover encases all of the torso and neck, and portions of other body areas. Heating may be distinctly non-uniform, being applied to the body surface only in special regions where the body's capacity for heat uptake may be relatively high. In sum, the system may monitor deep body core temperature, direct heat to the body core where it may be most needed, and controls therapy over time to restore normothermia.

To effect power control of a power amplifier 2 having three amplifier stages 3, 4 and 5 used to amplify input signals modulated in accordance with a variable envelope modulation scheme, there is used a power amplifier 2 having a gain which reduces as the supply voltage to the power amplifier 2 reduces, and the output power POUT of the power amplifier 2 is controlled by regulation of the supply voltage VS. Taking advantage of the reduction in gain of the power amplifier 2, it is ensured that, in respect of each respective amplifier stage 3, 4 and 5 and at each respective value of the supply voltage in the voltage control range, the output power POUT of the respective amplifier stage 3, 4 and 5 is less than the saturation output power PSAT of the respective amplifier stage 3, 4 and 5. As a result, distortion of the signal is reduced. The power control technique improves efficiency over known techniques of backing off the output power and using a variable gain amplifier stage to control the output power.

A nasopharyngeal airway for providing an air passage through a nose to a nasopharynx includes a cannula having a proximal open end, a distal closed end, and a sidewall surrounding a lumen of the cannula. The nasopharyngeal airway has an opening in the sidewall at a distal portion of the cannula for providing fluid communication between a distal portion of the lumen and the nasopharynx when the cannula is inserted into the nose and a conduit in the sidewall of the cannula, the conduit having an opening adjacent to the proximal open end of the cannula and a conduit opening in a distal portion of the cannula for providing fluid communication between the conduit and the distal portion of the lumen.

This invention teaches methods of combining ion implantation steps with in situ or ex situ heat treatments to avoid and / or minimize implant-induced amorphization (a potential problem for source / drain (S / D) regions in FETs in ultrathin silicon on insulator layers) and implant-induced plastic relaxation of strained S / D regions (a potential problem for strained channel FETs in which the channel strain is provided by embedded S / D regions lattice mismatched with an underlying substrate layer). In a first embodiment, ion implantation is combined with in situ heat treatment by performing the ion implantation at elevated temperature. In a second embodiment, ion implantation is combined with ex situ heat treatments in a “divided-dose-anneal-in-between” (DDAB) scheme that avoids the need for tooling capable of performing hot implants.

A monitoring device for monitoring a therapy device, for example, an anesthesia device or a respirator, is provided by which an alarm device for triggering an alarm when the value drops beyond a warning limit (4) is automatically activated when a determined therapy parameter drops beyond this warning limit (4). The warning limit (4) is set automatically in this case. In addition, a therapy device monitored by the monitoring device and especially an anesthesia device as well as a respirator are provided. A process for triggering an alarm as well as a process for treating a patient is also provided.

An improved technique for managing multiple virtual machines includes a presentation layer that receives user input for multiple virtual machines and renders output from the virtual machines in a unified presentation, which can be displayed to a user. In certain examples, Red / Green security is implemented by designating one virtual machine as a Green virtual machine and another as a Red virtual machine. Although different virtual machines are used, the presentation layer unifies the user's interaction with the virtual machines and reduces the need for the user to keep track of different virtual machines or to switch manually between them.

The invention relates to a field effect transistor in which the planar channel region on the upper surface of the elevation is extended in width by means of additional vertical channel regions on the lateral surfaces of the elevation. Said additional vertical channel regions connect directly to the planar channel region (vertical extended channel regions). Said field effect transistor has the advantage that a significant increase in the effective channel width for the current flow ION can be guaranteed relative to conventional transistor structures used up until the present, without having to accept a reduction in the achievable integration density. Said field effect transistor furthermore has a low reverse current IOFF. The above advantages are achieved without the thickness of the gate insulators up to the region of the charge transfer tunnels having to be reduced or a reduced stability.

A thermally insulating tile floor covering system comprising a water resistant, inorganic, thermal air-gap plastic barrier tile layer which is provided with a network of integral spaced plastic studs, legs or wall sections on the underside thereof, to form an interconnected space network between the undersurface of the flat plastic tile and the surface of a concrete floor supporting the tile. The space network provides an insulating thermal air gap barrier space to receive and circulate any water vapor penetrating up through the concrete floor.

A low water content soft lens for eye is provided, which includes a layer made of an acidic polymer and a basic polymer on at least a part of a surface of a base material containing a polysiloxane compound. Adhesion of the lens to the cornea during wear, which has hitherto been regarded as a problem in a conventional low water content soft lens for eye, can be reduced or avoided when using the low water content soft lens.

A change in the surface properties of apparatus for pharmaceutical preparation results from steam sterilization. This change may be avoided by the use of apparatus with more hydrophilic post-sterilization surfaces, e.g. those of gold. Hence there is provided a process for the preparation of a mixture comprising a discontinuous phase in a continuous phase which comprises using a mixing apparatus having a non-porous mixing surface which is repellant to the discontinuous phase and / or attractive to the continuous phase when the continuous phase is liquid or which is attractive to the discontinuous phase when the continuous phase is gaseous, whereby to improve the efficacy of the preparation of said mixture and / or to reduce physical degradation of said mixing surface, said surface if hydrophilic being more hydrophilic after sterilization than is stainless steel and if hydrophobic being more hydrophobic after sterilization than is stainless steel.

The ECC circuit generates the first syndrome of write data, which have not been written to the memory. The EDC circuit generates the second syndrome of verification read data, which have been written to the memory. The EDC circuit detects errors due only to the “read disturb phenomenon” using the second syndrome, the errors occurring in data scanned from the memory. The ECC circuit detects and corrects errors due to the “program disturb phenomenon” and the “read disturb phenomenon” using the first syndrome, the errors occurring in the data in which the errors due only to the “read disturb phenomenon” have been detected. As a result, both the circuit size and the processing time can be reduced.

Systems and methods for modeling the interactions of the several genes, proteins and other components of a cell, employing mathematical techniques to represent the interrelationships between the cell components and the manipulation of the dynamics of the cell to determine which components of a cell may be targets for interaction with therapeutic agents. A first such method is based on a cell simulation approach in which a cellular biochemical network intrinsic to a phenotype of the cell is simulated by specifying its components and their interrelationships. The various interrelationships are represented with one or more mathematical equations which are solved to simulate a first state of the cell. The simulated network is then perturbed by deleting one or more components, changing the concentration of one or more components, or modifying one or more mathematical equations representing the interrelationships between one or more of the components. The equations representing the perturbed network are solved to simulate a second state of the cell which is compared to the first state to identify the effect of the perturbation on the state of the network, thereby identifying one or more components as targets. A second method for identifying components of a cell as targets for interaction with therapeutic agents is based upon an analytical approach, in which a stable phenotype of a cell is specified and correlated to the state of the cell and the role of that cellular state to its operation. A cellular biochemical network believed to be intrinsic to that phenotype is then specified by identifying its components and their interrelationships and representing those interrelationships in one or more mathematical equations. The network is then perturbed and the equations representing the perturbed network are solved to determine whether the perturbation is likely to cause the transition of the cell from one phenotype to another, thereby identifying one or more components as targets.

The invention discloses a preparation method of LCZ696 intermediate and relates to the technical field of preparation of an aromatic nucleus compound containing 2 benzene rings and 1 chiral center. The preparation method includes the steps of S1, allowing benzyl magnesium bromide to react with methyl oxalyl chloride to obtain a compound as shown in formula I; S2, allowing the compound as shown in formula I to have a bromination reaction with a bromination reagent to generate a compound as shown in formula II; S3, coupling the compound as shown in formula II with phenylboronic acid to obtain a compound as shown in formula III; S4, performing reductive ammoniation on the compound as shown in formula III to obtain a compound as shown in formula IV; S5, applying Boc to the compound as shown in formula IV to obtain a compound as shown in formula V; S6, performing ester group reduction on the compound as shown in formula V to obtain a compound as shown in formula VI. The preparation method has the advantages that overall raw material consumption is lowered, and product productivity and market competiveness are increased; by the overall process optimization, the reaction of each step can be performed and controlled easily, the use of heavy metal catalysts is reduced and avoided, and accordingly the quality index of the final product is increased, and an economic and environment-friendly process route is developed.

A method and a trolley for facilitating a passenger's way through an airport terminal, and improved methods for boarding aircrafts. The trolley may include an interface, such as a boarding card reader, for receiving information identifying the passenger and / or the passenger's flight. Mobile wireless communication means may be provided at the trolley for receiving airport information data, such as flight departure gate, delay or cancellation information, from a computer network within an airport terminal. Data output means are provided to communicate information to the passenger. The trolley may be X-ray compliant. A communication interface may be provided at the trolley for communicating with a portable device, such as a smartphone or equivalent means of the passenger. Individually selected information based on passenger identity, destination, position or past collection of passenger behaviour may be disseminated to passengers on an individual basis. Passengers may be allowed to pass a gate for aircraft boarding only when called in accordance with a predetermined boarding sequence on the basis of, e.g., seat number or seat row.

A liquid discharging apparatus includes a print head that discharges a liquid, a carriage that is mounted on the print head, a control signal generation circuit, a drive signal generation circuit, a first cable through which a drive signal generation control signal is transmitted to the drive signal generation circuit, a second cable through which a drive signal is transmitted to the print head, a control circuit substrate on which the control signal generation circuit is provided, and a drive circuit substrate on which the drive signal generation circuit is provided. The shortest distance between the control circuit substrate and the carriage is longer than the shortest distance between the drive circuit substrate and the carriage. The drive circuit substrate is provided at a position where a region in which the carriage moves and at least a part of the drive circuit substrate overlap each other.

The invention discloses a medical suture wire with a natural antibacterial medicine release function and a preparation method thereof. A composite structure weaving process is used; silk fibroin is used as a coating carrier; natural antibacterial medicine is loaded; the antibacterial medicine suture wire with durable antibacterial performance is obtained; the suture wire material has the good mechanical property; meanwhile, the long-effect medicine slow release effect is realized; the bacteria can be inhibited or killed; the operation position infection is reduced.

A low water content soft lens for eye is provided, which includes a layer made of an acidic polymer and a basic polymer on at least a part of a surface of a base material containing a polysiloxane compound. Adhesion of the lens to the cornea during wear, which has hitherto been regarded as a problem in a conventional low water content soft lens for eye, can be reduced or avoided when using the low water content soft lens.

Firearms having a carrier assembly, buffer systems, and methods, having a carrier spindle, carrier saddle, or both, to reduce carrier tilt or wobble, reduce wear, or both. A carrier spindle can be located forward of the buffer spring, buffer weight, or both, and aft of the carrier assembly, and can slidably engage the carrier assembly. A spindle spring can bias the carrier spindle aft from the carrier assembly. In some embodiments, a taper on the carrier spindle facilitates separation of the lower receiver from the upper receiver. In some embodiments, the spindle spring is a helical spring that is loaded in compression and pushes the carrier spindle aftward. Some embodiments include a carrier saddle that supports the aft end of the carrier assembly. The carrier saddle can be raised, have a concave top surface, be made of a softer material, have dimensions within certain ranges, or a combination thereof.

A controller for a brushless motor that includes a PWM module configured in half-bridge or full-bridge mode. The PWM module outputs control signals for controlling the excitation of a winding of the motor, and one of the duty cycle and the period of the PWM module defines a time at which the winding is commutated.

Disclosed herein is a process for conditioning natural gas containing C3+ hydrocarbons, so that it can be used as combustion fuel to run gas-powered equipment, including gas engines and turbine-driven compressors, in the gas field or the gas processing plant. The claimed process use glassy polymeric membranes that are preferentially permeable to methane over C2+ hydrocarbons to produce a partially purified methane stream. The process operates at a stage cut of at least about 5%.

When a host system outputs a read command to a memory controller, it measures a load count of a memory area on which a read access load is imposed. Then, when the host system judges that the load count of a memory area reaches a predetermined count, it causes the memory controller to perform an error detection on the memory area. Further, when the host system finds that an error occurs in the memory area, it causes the memory controller to perform an error correction on the memory area. This can avoid or reduce unintended rewriting due to repeated readouts.

An anatomically designed egg-shaped or elliptical-shaped nasopharyngeal airway for providing a comfortable and safe air passage through a nose to a nasopharynx includes a cannula having a proximal open end, a distal end, and a sidewall surrounding a lumen of the cannula. The nasopharyngeal airway has a port, which includes two or more openings separated by one or more bridges, in the sidewall, at a distal portion of the cannula. Upper and lower conduits may be located in channels of the sidewall of the cannula for delivery of oxygen and measurement of CO2 or other purposes.

When a host system outputs a read command to a memory controller, it measures a load count of a memory area on which a read access load is imposed. Then, when the host system judges that the load count of a memory area reaches a predetermined count, it causes the memory controller to perform an error detection on the memory area. Further, when the host system finds that an error occurs in the memory area, it causes the memory controller to perform an error correction on the memory area. This can avoid or reduce unintended rewriting due to repeated readouts.

The invention relates to an inspection device for a production machine, in particular, a bottling plant 1 with a filling device 7 or a filling and sealing device 13, with a stream of products (5) consisting of one or more columns, wherein the inspection device is arranged in the production machine, advantageously in the bottling plant 1, directly after the filling device 7 or the filling and sealing device 13 or before a separating device 23, so that the products 5 are inspected before the separation 23 or packaging 25 of the products 5. Furthermore, the invention relates to an inspection method for a production machine, in particular, for a bottling plant 1, in which an inspection device consisting of a source 17 and a sensor 19 scans several products 5 perpendicular or diagonal to the product motion B.