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Zinc sulfate syrup oral liquid preparation

A liquid preparation, zinc sulfate technology, applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, drug delivery, etc. Effect

Active Publication Date: 2012-10-10
MAYINGLONG PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although there is no international limit on the content of 5-HMF in invert syrup, it is a by-product harmful to the human body after all.

Method used

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  • Zinc sulfate syrup oral liquid preparation
  • Zinc sulfate syrup oral liquid preparation
  • Zinc sulfate syrup oral liquid preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A kind of zinc sulfate syrup oral liquid preparation, its preparation method is as follows:

[0018] Take 650g of sucrose and add 350mL of purified water, heat to 95°C and stir to dissolve, then cool to 60°C to obtain solution A;

[0019] Dissolve 0.48g of ethylparaben in 3mL of 95v / v% ethanol, add it to solution A, stir well to obtain solution B;

[0020] Dissolve 2g of zinc sulfate in 80mL of purified water and add it to solution B, stir well to obtain solution C;

[0021] 0.50g citric acid (C 6 h 8 o 7 ·H 2 O) Stir and dissolve with 80mL of purified water, add it to solution C, and stir well to obtain solution D;

[0022] Take 3.50g sodium citrate (C 6 h 5 o 7 Na 3 2H 2 O), add 200mL of purified water, heat in a water bath to 55°C and stir to dissolve, then add the obtained solution into solution D under stirring until the pH is 5.0-5.2, stop adding, and stir evenly;

[0023] Finally, in a static state, add water to 1000ml, and stir for 15 minutes to obtai...

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Abstract

The invention belongs to the technical field of oral liquid preparations and particularly discloses a zinc sulfate syrup oral liquid preparation, which is suitable for supplementing zinc for user groups with zinc deficiency. Main medicine is zinc sulfate, cane sugar is a sweetening agent, ethylparaben is a preservative, and citric acid and sodium citrate are pH stabilizers. Experiments show that the pH value of the oral liquid preparation added with the pH stabilizers is stabilized in a certain range in the specified validity period.

Description

technical field [0001] The invention relates to the technical field of oral liquid preparations, in particular to a zinc sulfate syrup oral liquid preparation, which is suitable for zinc supplementation for zinc-deficient people. Background technique [0002] Zinc is an important component of many enzymes in the body, which can promote growth and development, improve taste and so on. When lacking, growth stagnation, reproductive impotence, difficult wound healing, body weakness, conjunctivitis, stomatitis, glossitis, loss of appetite, chronic diarrhea, loss of taste and neurological symptoms may also occur. Zinc is especially important for the growth and development of children. Zinc sulfate syrup can be used for zinc supplementation for zinc deficiency patients. [0003] National Drug Standards, Local Standards of Chemical Drugs, National Standard Volume IV WS-10001-(HD-0382)-2002 stipulates that the pH value of zinc sulfate syrup is 3.5-5.5. The validity period of the z...

Claims

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Application Information

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IPC IPC(8): A61K33/30A61K47/12A61K9/08A61P3/12
Inventor 陈平夏军喻红王晓伟叶琦袁义华
Owner MAYINGLONG PHARMA GROUP