In-water type mecamylamine and celery seed oil nanoemulsion antihypertensive medicine

Abstract

The invention discloses an in-water type mecamylamine and celery seed oil nanoemulsion antihypertensive medicine which comprises the following raw materials by mass percent: 1-20% of mecamylamine, 15-40% of surfactant, 1-20% of cosurfactant, 1-25% of celery seed oil and the balance of distilled water. The nanoemulsion droplet particles are small, are uniformly distributed and have small viscosity and good liquidity. The nanoemulsion organically combines the water-soluble medicine mecamylamine and the fat-soluble celery seed oil together, so the dissolution and infiltration capacities of the celery seed oil are improved, and the stability and pharmaceutical effect of the mecamylamine are enhanced. After the mecamylamine and the celery seed oil are prepared into the nanoemulsion, the advantages of the mecamylamine and the celery seed oil are combined together, so the antihypertensive effect is obviously improved, the pharmaceutical half-life period of the antihypertensive medicine is prolonged, and the medicine administration times are reduced.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new dosage form of an antihypertensive drug mecamylamine and celery seed oil, in particular to a nanoemulsion antihypertensive drug of mecamylamine and celery seed oil. Background technique [0002] Mecamylamine, methyl(2,3,3-trimethyltrinorbornan-2-yl)amine; N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride (1:1), CAS No. : 60-40-2, molecular formula: C 11 h 2l N. Molecular weight: 203.7521. The shape is white crystalline powder. The melting point is 245.5-246.5°C. Soluble in water, ethanol, glycerin. It is an N1 cholinergic receptor blocker, a ganglion blocking drug, and a non-depolarizing competitive antagonist. Ganglion-blocking drugs. Anti-ganglionic action to lower blood pressure, fast and lasting antihypertensive effect, and not easy to produce drug resistance. Celery seeds are taken from the flowers of celery, so the seeds are very small in shape, oval in sh...

AI Technical Summary

Problems solved by technology

There are antihypertensive drugs such as mecamylamine tablets on the market, and the use of celery seed oil is also available. Although it can be absorbed from the gastrointestinal tract after oral administration, the absorption is not complete. In addition, the dissolution rate of the drug is slow and the bioavailability is poor. Coupled with the slow action of mecamylamine, the medicinal effects of mecamylamine and celery seed oil cannot be utilized