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Method for improving humidity resistance of extract powder of Qiluyishen tablets

A moisture-proof performance and extract powder technology, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the deformation of tablet cores and affect the large-scale production of Qilu Yishen Tablets, Sticking and other problems, to achieve the effect of improved anti-corrosion, superior moisture-proof effect, and easy degradation

Active Publication Date: 2012-10-31
GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
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AI Technical Summary

Problems solved by technology

[0004] In the course of the research, we found that crushing some of the starchy medicinal materials in the formula into powder and mixing them with the extract powder for granulation can temporarily solve the problem of granulation, but it has not been solved in essence. The problem of moisture absorption of extract powder, in the process of tablet compression and coating, there will still be production problems such as sticking, punching and deformation of tablet core due to moisture absorption
It affects the large-scale production of Qilu Yishen Tablets and the shelf life after production

Method used

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  • Method for improving humidity resistance of extract powder of Qiluyishen tablets
  • Method for improving humidity resistance of extract powder of Qiluyishen tablets
  • Method for improving humidity resistance of extract powder of Qiluyishen tablets

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Embodiment Construction

[0035] The present invention will be further described below in conjunction with the examples and experimental results.

[0036] The following examples adopt chitosan produced by Jinhu Shell Products Co., Ltd.

[0037] One, the measuring method of the critical relative humidity of sample in the embodiment is:

[0038] Place the weighing bottle in a glass desiccator and dry it in a phosphorus pentoxide desiccator to constant weight. Fill the bottom with different saturated salt solutions (respectively CH 3 COOK, MgCl 2 、K 2 CO 3 , NaBr, KI, NaCl, KCl, Na 2 HPO 4 Saturated saline solution, relative humidity of 20%, 33%, 43%, 58%, 69%, 75%, 84%, 98%) was placed in a constant temperature incubator at 25 °C for 24 hours. Take 14 parts of Qilu Yishen extract powder prepared according to the process, divide it into 2 groups, each group has 7 parts, each part is about 1 g, put it at the bottom of the weighing bottle with constant weight, place it in a desiccator after accurat...

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Abstract

The invention discloses a method for improving humidity resistance of extract powder of Qiluyishen tablets. The method comprises the steps as follows: the raw material of Qiluyishen tablets is extracted to prepare a thick extract; water is added to disperse 1.0-3.0% (by weight) of chitosan, and the chitosan is added to the thick extract, so that the chitosan is dissolved and swelled to colloid and uniformly wrap the thick extract; and the product obtained in last step is dried and crushed to obtain the extract powder. Compared with the prior art, the method can improve humidity resistance and fluidity of the extract powder of Qiluyishen tablets drastically, is safe, free of toxity, and easy to degrade, and further improves the technology efficiency.

Description

technical field [0001] The invention relates to the moisture-proof technology of traditional Chinese medicine preparations, in particular to a method for improving the moisture-proof performance of Qilu Yishen tablet extract powder. Background technique [0002] The whole extract of traditional Chinese medicine is the main form of modern Chinese medicine preparation. Due to the complex composition of traditional Chinese medicine, most of which contain moisture-absorbing ingredients such as sugars, tannins, and inorganic salts, the whole extract of traditional Chinese medicine made after extraction and separation has varying degrees of moisture absorption. Moisture absorption, leading to softening, agglomeration, and reduced fluidity of Chinese medicine solid preparations due to moisture absorption of extract powder during the molding process, which brings difficulties to the production of medicines; it even leads to mildew of Chinese medicine preparations, thus affecting medi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61K9/20A61K47/36A61P1/14
Inventor 黄光亮许小春罗建明黄子健王莎黎洪
Owner GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
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