Detection method of pulse-an granules

A detection method and technology of Mai'an granules are applied in the field of detection of active ingredients in traditional Chinese medicine formulations, which can solve the problems of no quality index, no identification method, no detection, etc., and achieve the effect of safe and effective medication.

Inactive Publication Date: 2012-10-31
SICHUAN FENGCHUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in addition to the determination of citric acid in the original standard, there is no other test for the two traditional Chinese medicines of northern hawthorn and malt in the prescription, and there are neither quality indicators nor identification methods for these quality indicators.
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Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0024] Example 1:

[0025] 【Prescription】 Northern Crataegus 100g Malt 100g

[0026] [Preparation method] The above two flavors, the northern hawthorn mashed and the malt are decocted twice, 1 hour each time, the decoction is combined, filtered, and concentrated to a clear paste with a relative density of 1.30 and a temperature of 80°C, and an appropriate amount of ethanol , Stir well, take 1 part of clear paste, add 2 parts of sucrose, 1.2 parts of dextrin, make granules, dry, sieving, and get, divide into 20g bags.

[0027] 【Properties】 The product is brownish-yellow to brown granules; it tastes sweet and slightly sour.

[0028] [Identification] (1) Thin-layer identification of Hawthorn

[0029] Take 30g of this product, add 60ml of ethyl acetate, sonicate for 20 minutes, filter, evaporate the filtrate, add 1ml of methanol to the residue to dissolve, as the test solution; take another reference substance of oleanolic acid and add methanol to make each 1ml The solution containing 0...

Example Embodiment

[0041] Example 2:

[0042] 【Prescription】 Northern Crataegus 100g Malt 100g

[0043] [Preparation method] The above two flavors, the northern hawthorn mashed and the malt are decocted twice, 1 hour each time, the decoction is combined, filtered, and concentrated to a clear paste with a relative density of 1.30 and a temperature of 80°C, and an appropriate amount of ethanol , Stir well, take 1 part of clear paste, add 2 parts of sucrose, 1.2 parts of dextrin, make granules, dry, sieving, and get, divide into 20g bags.

[0044] [Identification] (1) Thin-layer identification of Hawthorn

[0045] Take 50g of this product, add 100ml of ethyl acetate, sonicate for 40 minutes, filter, evaporate the filtrate, add 1.5ml of methanol to dissolve the residue, and use it as the test solution; take the oleanolic acid reference substance and add methanol to make each 1ml contains 0.3mg of the solution, as the reference solution; draw 108μl of each of the above two solutions, respectively spot on ...

Example Embodiment

[0053] Example 3:

[0054] 【Prescription】 Northern Crataegus 100g Malt 100g

[0055] [Preparation method] The above two flavors, the northern hawthorn mashed and the malt are decocted twice, 1 hour each time, the decoction is combined, filtered, and concentrated to a clear paste with a relative density of 1.30 and a temperature of 80°C, and an appropriate amount of ethanol , Stir well, take 1 part of clear paste, add 2 parts of sucrose, 1.2 parts of dextrin, make granules, dry, sieving, and get, divide into 20g bags.

[0056] [Identification] (1) Thin-layer identification of Hawthorn

[0057] Take 40g of this product, add 80ml of ethyl acetate, sonicate for 30 minutes, filter, evaporate the filtrate, add 0.5ml of methanol to the residue to dissolve, as the test solution; take another reference substance of oleanolic acid and methanol to make each 1ml contains 0.3mg of the solution as a reference solution; pipette 8μl of each of the above two solutions, respectively spot on the sam...

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PUM

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Abstract

The invention provides a detection method of pulse-an granules (particle). The detection method comprises projects of identification and content determination, the identification comprises thin layer chromatography of north hawthorn and thin layer chromatography of malt in the pulse-an granules; and the content determination comprises content determination of citric acid in the pulse-an granules. The detection method conducts effective quality control on all traditional chinese medicinal materials in a prescription, can better and comprehensively reflect quality of the pulse-an granule drug, and can effectively prevent illegal manufacturers from producing fake pulse-an granules so as to guarantee safety and efficiency of pharmacy of the masses.

Description

technical field [0001] The invention relates to a method for detecting active ingredients in traditional Chinese medicine prescriptions, in particular to a method for detecting active ingredients in Maian Granules. Background technique [0002] Mai'an Granules (Granules) is a variety recorded in the first volume of traditional Chinese medicine preparations in the "Drug Standards of the Ministry of Health". The standard number is WS3-B-0115-89. The prescription is hawthorn and malt. It is a granule made of pure Chinese medicine agent. It can treat hyperlipoproteinemia, reduce serum cholesterol, prevent atherosclerosis, and also have certain effects on reducing triglyceride and β-lipoprotein. Mai'an Granules are commonly used medicines currently on the market for treating hyperlipoproteinemia, lowering serum cholesterol, preventing atherosclerosis, lowering triglycerides, and lowering β-lipoprotein. However, in addition to the determination of citric acid in the original sta...

Claims

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Application Information

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IPC IPC(8): G01N30/90G01N21/79
Inventor 钟茂团黎勇温国梁邹波
Owner SICHUAN FENGCHUN PHARMA
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