New medical application of rhodospirillum

A new-use technology for Rhodospirillum, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, and medical raw materials derived from bacteria, etc., and can solve problems such as unclear mechanisms of action

Inactive Publication Date: 2012-12-19
韩少坤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The phenomenon of endotoxin resistance has been recognized a century ago, but its mechanism of action has not been studied clearly, and whether the emergence of endotoxin resistance is related to the inhibition of apoptosis is also a question that has attracted much attention;

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1. Preparation of Rhodospirillum pharmaceutical preparations.

[0022] Rhodospirillum: Cells are arc-shaped or spiral, 0.8-1.5 μm wide, polar flagella move, cells divide in two, Gram staining is negative. The photosynthetic pigments are bacteriochlorophyll a and rhodospiraxanthin carotenoids. Rhodospirillum lives in the mud of lakes and ponds, and its cells like to grow photosynthetically and heterotrophically under anaerobic conditions under light. Type species: Rhodospirillum rubrum, Rhodopseudomonas palustris.

[0023] The formula of Rhodospira culture medium is: NH4Cl: 0.1g; NaHCO3: 0.1g; K2HPO4: 0.05g; CH3COONa: 0.1~0.5g; MgSO4·7H2O: 0.02g; NaCl: 0.05~0.2g; 97ml, 1ml trace element solution, pH 7.0, add 0.1% ~ 0.3% peptone. Add Rhodospirillum strains to the above medium, anaerobic culture under light at 25-35°C, the culture medium will slowly turn red, and after a week, the concentration of the bacteria solution can reach 3 billion per ml, and th...

Embodiment 2

[0024] Example 2. Animal experiments: verify the safety and effectiveness of Rhodospirillum preparations.

[0025] Add a large amount of Rhodospirillum preparations to the drinking water of poultry and livestock, or mix it into the feed for feeding. It is widely used in the breeding of chickens, ducks, geese, pigs, dogs, cattle and sheep, fish, shrimps, crabs, and mussels. It has not had any toxic and side effects in the past 19 years. It has been verified that Rhodospirillum has high safety and can treat skin bumps and gastrointestinal problems of poultry and livestock. Diseases, asthma and other diseases have special effects on the treatment of red and white dysentery. After feeding for a period of time, the skin and meat of poultry and livestock are fresh and tender, and the coat color is bright. Rhodospirillum preparations can improve the temperament of farmed animals and prevent mutual attacks within the farmed group, because it reduces the toxicity of endotoxin in the f...

Embodiment 3

[0026] Example 3. The Rhodospirillum preparation of the present invention is clinically used in the treatment of type I, II, III, and IV allergic diseases in humans, all of which show good therapeutic effects, and the results are immediate. When a large amount of Rhodospirillum enters the human stomach orally, the bacteria will immediately decompose and release endotoxin. Due to the anergy mechanism of the body's cells, tolerance to endotoxin will be generated, and oral immune tolerance will be established to desensitize . Clinically used to prevent and treat type I, II, III, IV allergic diseases such as eczema, urticaria, allergic asthma, diabetes, hyperthyroidism, uremia, lupus erythematosus, psoriasis, various ulcers and burns, various cancers It can also be used in the prevention and treatment of cardiovascular diseases such as arteriosclerosis and hypertension:

[0027] 1. Treatment of gastrointestinal allergy: It belongs to type I and type IV hypersensitivity diseases...

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PUM

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Abstract

The invention discloses a new medical application of rhodospirillum, namely the application of rhodospirillum in preparing a medicine for treating and preventing allergic diseases of types I, II, III and IV, which is mainly used for diminishing inflammation, clearing heat and relieving pain. No medicine with a real treatment effect on the hypersensitive allergic diseases is available except glucocorticoid and immunosuppressor. A great quantity of animal experiments prove that the rhodospirillum preparation is safe and effective; the rhodospirillum preparation is clinically used for preventing and treating the allergic diseases of types I, II, III and IV such as eczema, urticaria, allergic asthma, diabetes, hyperthyroidism, uremia, lupus erythematosus, psoriasis, various ulcers, burns and scales, various cancers and the like, and also can be used for preventing and treating the cardiovascular diseases such as arteriosclerosis, hypertension and the like; and a great quantity of clinical cases indicate that the effective rate of the rhodospirillum preparation in treating allergic diseases is 100%; the rehabilitation degree depends on the constitution and condition of patients; and younger patients enjoy a better long-term effect.

Description

technical field [0001] The invention discloses a new medical application of Rhodospirillum, that is, the application of Rhodospirillum in the preparation of medicines for treating and preventing type I, II, III, and IV allergic diseases, the main functions of which are anti-inflammatory, antipyretic and analgesic effects ; Belong to the field of medicine. Background technique [0002] The human immune system is the main biological defense system for identifying and resisting diseases. Under normal circumstances, this system does not cause immune damage to various tissues and organs in the human body, but under the stimulation of various factors, the immune function of the body is disordered, resulting in immune Various cellular functions of the system and their secreted factors are out of balance to produce diseases. Because the treatment of diseases caused by autoimmune abnormalities is quite difficult, oral immune tolerance provides a new way and idea for the treatment of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A61P29/00A61P37/08A61K35/741
Inventor 韩少坤
Owner 韩少坤
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