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Allergen microarray

A microarray, antigen-based technology used in the field of assessing whether a subject has developed or is at risk of developing asthma, conjunctivitis or rhinitis

Inactive Publication Date: 2013-01-23
MICROTEST MATRICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Thus, while it is relatively straightforward to determine whether a patient or subject displays an immune response to a particular antigen, there is no easy way to determine whether the same patient or subject is at risk of developing a more serious condition such as asthma, conjunctivitis, or rhinitis

Method used

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  • Allergen microarray
  • Allergen microarray
  • Allergen microarray

Examples

Experimental program
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Embodiment

[0115] group case study

[0116] The study included families whose offspring had atopic asthma. All asthmatics are atopic. Sibling duos (siblings) and trios with atopic asthma were collected over a 4-year period, mainly from pediatric and pulmonary centers. To avoid phenocopy, all patients met the following criteria: at least 3 generations of Sardinian origin and age >6 years at visit.

[0117] During the enrollment period, each subject was interviewed, had a physical examination to determine disease status, requested permission to use personal health records, and collected blood samples. Each participant signed an informed consent form approved by the local ethics committee (Azienda Sanitaria Locale number 8 protocol 24 / Comitato Etico / 02, authorization number 4737). Asthma was diagnosed by a pulmonologist, and lung function was evaluated by spirometry according to the standards of the American Thoracic Society (1): the forced expiratory volume at one time (FEV1) was expres...

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Abstract

The present invention relates to a method of assessing if a subject is at risk of developing or has already developed asthma, conjunctivitis or rhinitis. The invention further relates to antigen sets for use in such methods including identifying other suitable antigens correlated with asthma, conjunctivitis or rhinitis.

Description

[0001] The present invention relates to a method for assessing whether a subject has developed or is at risk of developing asthma, conjunctivitis or rhinitis. The invention also relates to a collection of antigens for use in the method comprising identifying antigens associated with such risk. Background technique [0002] Asthma is widely recognized as a major global health problem. It has been one of the most common diseases affecting adults and children over the past five decades, causing as many as 300 million cases worldwide, and its frequency is worryingly increasing every year. [0003] Both genetic factors (cytokines and immune response genes) and environmental factors (eg, viral infections, allergens, and occupational exposures) are associated with asthma susceptibility, age of onset, and severity. However, the pathogenesis of this disease has not been fully elucidated. [0004] A major risk factor is the development of an immune response to foreign antigens that is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N2800/162G01N33/6854G01N2800/122
Inventor 安德烈亚·克里桑蒂塔尼亚·多托里尼
Owner MICROTEST MATRICES