Processed product of polygala tenuifolia with mangnolia officinalis and preparation method of same
A technology of Magnolia officinalis and Polygala, applied in the field of medicine, can solve the problems of restricting the safety, effective application and low safety of Polygala, and achieve the effects of calming the nerves, reducing gastrointestinal motility, and reducing side effects.
Active Publication Date: 2014-12-31
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology
The low safety of clinical use restricts the safe and effective clinical application of polygala
Method used
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[0029] 1. Experimental research
[0030] 1 Experimental materials
[0031] 1.1 Experimental animals
[0032] Kunming mice, 18-22g, provided by the Experimental Animal Center of Chengdu University of Traditional Chinese Medicine, certificate number: scxk (Sichuan) 2009-11.
[0033] 1.2 Test drugs, main reagents, drugs and equipment
[0034] 1.2.1 Test drug
[0035] Polygala tenuifolia: purchased from the Chinese medicinal material market in the lotus pond of Chengdu City, and identified as the root of Polygala tenuifolia willd by Professor Lu Xianming of Chengdu University of Traditional Chinese Medicine, belonging to the 2010 edition of the "Chinese Pharmacopoeia".
[0036] Magnolia officinalis: purchased from the Chinese herbal medicine market in the lotus pond of Chengdu, and identified as Magnolia officinalis Rehd.et Wils. and Magnolia officinalis Rehd.et Wils.var.biloba Rehd.et Wils. by Professor Lu Xianming of Chengdu University of Traditional Chinese Medicine. Root bark is a variet...
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The invention belongs to the field of medicine, and particularly relates to a processed product of polygala tenuifolia with mangnolia officinalis and a preparation method of the processed product. The invention aims at solving the technical problems of easing the side effect of polygala tenuifolia to stomach and intestine ,retaining the effects of soothing the nerves, eliminating phlegm and inducing resuscitation of polygala tenuifolia. The preparation method of the processed product provided by the invention comprises the following steps: 1, preparing mangnolia officinalis and polygala tenuifolia based on crude drug ratio in part by weight: 1-3 parts of mangnolia officinalis and 1 part of polygala tenuifolia or 2 parts of high-class mangnolia officinalis and 1 parts of polygala tenuifolia; 2, preparing mangnolia officinalis juice: mangnolia officinalis herbs are boiled in water and filtered to get mangnolia officinalis juice; and 3, processing the polygala tenuifolia with the mangnolia officinalis juice: the mangnolia officinalis juice obtained in step 1 is used to the soak polygala tenuifolia until the mangnolia officinalis juice are totally absorpt by the polygala tenuifolia, the polygala tenuifolia is roasted at the temperature of 60-180 DEG C for 6-18 minutes, and the processed product of polygala tenuifolia with mangnolia officinalis is obtained after drying. The processed product of polygala tenuifolia with mangnolia officinalis can effectively reduce the side effects of polygala tenuifolia that restrains stomach and intestine moving and retain the curative effects of relieving cough, eliminating phlegm and soothing the nerves, so as to achieve the purposes of reducing side effects and retaining curative effect. The invention has clinical application values.
Description
Technical field [0001] The invention belongs to the field of medicine, and specifically relates to a processed product of Magnolia and Zhiyuanzhi and a preparation method thereof. Background technique [0002] Polygala is a traditional Chinese medicine for tranquilizing the nerves. It has the effect of calming the nerves and calming the mind. It is mainly used for the treatment of restlessness, palpitations, insomnia, and forgetfulness. Modern pharmacological studies have shown that Polygala extract has sedative and anti-convulsant effects on the central nervous system, and its root bark, whole root and muxin are fed to mice with sedative and tranquilizing effects. However, Polygala products are more toxic. Studies have shown that Polygala can significantly inhibit gastrointestinal motility and hinder gastrointestinal digestion, showing obvious side effects such as flatulence, gastric mucosal damage and inhibition of digestive enzymes. The safety of clinical use is low, which re...
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IPC IPC(8): A61K36/69A61P25/08A61P25/20
Inventor 王建夏厚林马骁罗凤娟吴纯洁曾南黄聪袁奕田徽黄立华
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE