Nux vomica alkaloid patch for treating local myalgia and arthralgia and preparation method

A technology for joint pain and nuxe nux, which is applied in the direction of non-central analgesics, medical preparations containing active ingredients, anti-inflammatory agents, etc. It can solve the problems of stopping drug absorption, etc., and achieve high content of active ingredients and good sticking performance , the effect of high drug concentration in skin and muscle

Inactive Publication Date: 2014-08-20
XIANGTAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is reported in the literature that part of strychnine and the total alkaloids of Strychnium Semen were removed to make gel respectively. Stronger; but the gel needs to be administered several times a day, and it is easy to be wiped off by clothes during use, which will stop the drug from being absorbed through the skin

Method used

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  • Nux vomica alkaloid patch for treating local myalgia and arthralgia and preparation method
  • Nux vomica alkaloid patch for treating local myalgia and arthralgia and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Take 1.0ml of 0.1mg / ml strychnine strychnine alkaloid extract solution, add 0.1g of azone, then add acrylate pressure-sensitive adhesive to 10.0g, mix well, and evenly coat on the release layer, Dry at 80°C for 20 minutes, compound with backing materials such as PVC or non-woven fabric, punch out to a certain size and specification, and strychnine and strychnine account for 0.1% of the drying matrix.

Embodiment 2

[0044] Take 1.0ml of 5.0mg / ml strychnine strychnine alkaloid extract solution, add acrylate pressure sensitive adhesive to 10.0g, mix well, evenly spread on the anti-adhesive layer, dry at 80°C for 20 minutes, use Composite backing materials such as PVC or non-woven fabrics, punched and cut into certain sizes and specifications.

Embodiment 3

[0046] Take 1.0ml of strychnine strychnine alkaloid extract solution of 50.0mg / ml, add 1.5g of propylene glycol, 0.5g of oleic acid, then add acrylate pressure-sensitive adhesive to 10.0g, mix well, and evenly spread on the On the adhesive layer, dry at 80°C for 20 minutes, compound with backing materials such as PVC or non-woven fabric, and punch out to a certain size and specification.

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Abstract

The invention discloses a nux vomica alkaloid patch for treating local myalgia and arthralgia and a preparation method. The patch consists of a medicine storage magazine, a backing layer and an anti-sticking layer, wherein the medicine storage magazine comprises nux vomica total alkaloid with parts of strychnine removed, pressure-sensitive adhesive and transdermal absorption accelerant; the nux vomica has an obvious clinic curative effect on local myalgia and arthralgia caused by rheumatism and traumatic injury; the main active ingredient of the nux vomica is nux vomica total alkaloid, but the strychnine has the disadvantages of big toxin and high ratio in total alkaloid amount, and is likely to generate the toxic symptom when being orally taken; and a poisoning risk due to the damage of patient keratoderma may be caused even if the nux vomica is externally applied. Compared with the nux vomica total alkaloid patch nux vomica alkaloid patch, the external transdermal absorption rate of the strychnine in the patch disclosed by the invention is obviously lowered, and the concentration of the strychnine in the skin and the muscle on the belly pasting position of a mouse is obviously lowered. Compared with the traditional black plaster and adhesive plaster matrix in the traditional Chinese medicine, the patch disclosed by the invention is characterized by having the characteristic that a high-polymer pressure-sensitive adhesive with smaller skin irritation and irritability is selected, and the adhesion can be better. The patch disclosed by the invention has the advantages of high effective ingredient content, big transdermal absorption amount, and high medicine concentration of skin and muscle of the pasted position. The patch production equipment and the technology are mature, and the invention is suitable for large-scale industrial production.

Description

technical field [0001] The invention relates to a patch prepared by removing part of strychnine from the total alkaloids of Nuxebra chinensis and polymer pressure-sensitive adhesive. Background technique [0002] Local muscle or joint pain caused by rheumatism or bruises is a common and frequently-occurring disease in people's lives. It is an economical and practical treatment for patients to apply traditional Chinese medicine plasters on their own. Currently commercially available Chinese medicine plasters are mainly composed of Chinese medicine compound adhesive plasters and black plasters, and some patients cannot tolerate them because of skin irritation and anaphylaxis. Due to the low content of active ingredients in traditional Chinese medicine plasters, it is difficult to reach the affected area through the skin of the application site, and the clinical curative effect cannot be fully exerted. [0003] Nuxychia is a species recorded in Part One of the Chinese Pharmaco...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/56A61K9/70A61P29/00
Inventor 汤淮波胡海肖筱武杨占京张水香罗青魏爱丽
Owner XIANGTAN UNIV
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