30 results about "Toxic symptom" patented technology

The object of the present invention is to provide a composition which is effective in retarding or preventing the development of energy decrease, appearance change, etc. of humans and animals due to aging, and is highly safe even with a long period of taking. The present invention relates to an antiaging composition which comprises reduced coenzyme Q as an active ingredient. By feeding mice which develop the aging symptom early (aging-accelerated model mice) with a feed containing reduced coenzyme Q10 for a long period of time, aging process was prevented and retarded. Furthermore, aging-accelerated model mice fed with reduced coenzyme Q10 for a long period of time showed no toxic symptom, thus it was found that the antiaging composition comprising a composition containing said substance can be made into a safe antiaging composition capable of being taken for a long period of time.

The invention discloses an aquaculture pond detoxification composition which is characterized by containing polymeric ferric sulfate, calcium peroxide, humic acid and zeolite powder. The four ingredients can be directly and uniformly mixed by a stirrer to form powder or processed by a tablet machine to form granules. The granules can be directly thrown into a fish pond when in use. The composition can be used for quickly relieving and reducing the toxic symptoms of aquatic animals caused by such harmful substances in the aquaculture pond as ammonia nitrogen, hydrogen sulfide, algal toxins, heavy metals and pesticides, and also quickly and effectively increasing the dissolved oxygen in the water body, thereby being suitable for high-density aquaculture water bodies.

The invention discloses a data retrieval system of common poisons. The system includes 403 types of poisons, including various pesticides, natural toxins, poisonous animals and plants, heavy metals and the like, and provides relevant information on toxic symptoms, assay technologies, site disposal, clinical diagnosis and treatment principles. In the system, data and application of the system are operated on a server without installation of any software, a database can be logined remotely and accessed through common browsers, two efficient retrieval routes of poison names and clinical symptoms are set, and various basic databases are related through the poison names, which is convenient to use with full and has accurate information and provides technical guarantees for the quick querying and disposal of possible poisoning accidents.

The invention provides a method for repairing soil heavy metal cadmium pollution through an endive-oil sunflower crop rotation mode. According to the method, endives and oil sunflowers are planted in the soil of heavy metal compound pollution in the endive-oil sunflower crop rotation mode according to the natural growing periods of the endives and the oil sunflowers, and conventional cultivation is conducted. Both the endives and the oil sunflowers can grow normally in the cadmium-polluted soil, no obvious toxic symptom occurs, and the yield of the endives and the oil sunflowers is not influenced. In addition, the biomass of the overground part is large, a large quantity of various heavy metals can be absorbed and accumulated, especially the content of the heavy metal cadmium in the plants is obviously larger than the soil background value, and the enrichment level is reached. By the adoption of the method, cultivation is easy, the management cost is low, the oil sunflowers have quite high edible value and medicinal value, the endives contain a large amount of protein and have quite high feeding value, the heavy metals can be prevented from entering the food chain again through simple treatment, and high economic income can be obtained while pollution treatment is achieved.

The invention discloses a method used for preventing alien weed Alternanthera philoxeroides with pathogenic fungus. The method comprises following steps: preparation of a fluid nutrient medium; culturing of alternaria alternata; preparation of alternaria alternata toxin, and application of alternaria alternata toxin, wherein active toxin is prepared into a mixed solution with a concentration ranging from 125 to 2000<mu>g / ml, and the mixed solution is sprayed onto Alternanthera philoxeroides, so that obvious toxic symptoms of Alternanthera philoxeroides can be observed in three days, and weeds are killed. The alternaria alternata toxin possesses killing effect on most symbiotic weeds of Alternanthera philoxeroides. Operation of the preparation method of the liquid nutrient medium is simple; culture medium raw materials are easily available; needed equipment is simple; stability of the used toxin is high; extraction purification technology is simple; large-scale batch production can be realized; added accessory ingredients possess excellent synergistic effects on alternaria alternata toxin; the alternaria alternata toxin is applied via stem and leaf spraying; application is convenient; target weed Alternanthera philoxeroides can be killed effectively, and most symbiotic weeds can be killed at the same time; and environmental safety of the method is relatively high.

The present invention discloses a use of N-acetyl-D-glucosamine or pharmaceutically acceptable salts thereof in the manufacture of a medicament for treating local lesions or systematic symptoms caused by infections of virus or bacteria. A parenteral preparation comprising N-acetyl-D-glucosamine or pharmaceutically acceptable salts thereof as active component is capable of controlling systematic toxic symptoms caused by infections of virus and bacteria and local and systematic lesions caused by endotoxins and exotoxins, and exhibits an excellence rate of 90%.

The invention discloses a compound feed additive with an antioxidant function capable of relieving mycotoxicosis of a piggy. The compound feed additive comprises the following components in percentage by weight: 1-2% of vitamin A, 3.23-4% of vitamin C, 5.11-6% of vitamin E, 3-4% of selenium yeast, 2-3% of grape seed proanthocyanidins and 81-85% of mixture of rice chaff and husks. The compound feed additive disclosed by the invention aims at a toxic mechanism of mycotoxin, selects a natural antioxidant as the raw material, adopts a reasonable compounding ratio of the components and has better relieving effects on oxidative injuries, structural damage and growth inhibition, which are caused by the mycotoxin, of intestinal tracts of an animal; besides, the compound feed additive with the antioxidant function, disclosed by the invention, has a better relieving effect on various animal toxic symptoms caused by the mycotoxin in the practice production; the components of the additive disclosed by the invention have the characteristics of safety and nutrition, micro nutritional substances in the feed cannot be adsorbed, and the breeding efficiency can be improved.

The invention relates to an antidote for preventing and treating livestock aflatoxicosis. The weight ratio of active ingredients, namely, glutathione and berberine, is (1:20)-(20:1). Compared with a common antidote, the livestock feed antidote provided by the invention is simple to prepare and reasonable in compatibility and can remarkably relieve the toxic symptoms of the livestock and is proved by experiments to have a special effect on preventing and treating livestock aflatoxicosis; and without Western medicine components in additives, the antidote avoids toxic and side effects, drug resistance and pollution.

The invention relates to a veterinary compound oral nano-emulsion containing zinc chelate, selenium and multivitamins and a preparation method for the same, wherein the veterinary compound oral nano-emulsion comprises the following components: zinc gluconate, a chelant, vitamin A, vitamin D3, vitamin E, sodium selenite, an emulsifier, an emulsifying aid, a preservative, an antioxidant and water. The veterinary compound oral nano-emulsion disclosed by the invention can comprehensively supplement vitamins; moreover, zinc can enhance esterase activity and thus promoting absorption for vitamin A,vitamin D can promote skeletal development, and selenium can promote absorption for vitamin E and enhance the antioxidation of vitamin E; and when toxic symptom appears due to excessive selenium, vitamin E can enhance excretion for selenium and decrease toxicity.

Six-ingredient rehmannia pill is a famous ancient medicine which is applied for almost a thousand years, and is also a popular drug which is often taken by people for a long term in pursuit of health care and body building, however, alisma in the raw material medicine can cause gastroenteritis, nausea, vomiting, dizziness, eye faint, abdominal pain, diarrhea, limb weakness, loss of appetite, itching, angioedema, allergic skin rashes or even respiratory paralysis and other poisoning symptoms. The ancient and modern medical literature points out that the alisma can not be taken for a long term or with a large amount at early time, or else, the long-term taking of the alisma can also cause sever side effects such as kidney toxicity and thus resulting in acute tubular necrosis and the like. The traditional Chinese medicine phellodendron has the function of reducing renal fire of the alisma in the six-ingredient rehmannia pill. The six-ingredient rehmannia pill is used to replace the alisma, is improved into a new six-ingredient rehmannia pill, not only can maintain the functions of nourishing yin and tonifying the kidney of the ancient six-ingredient rehmannia pill, but also can avoid adverse reactions caused by the use of the alisma, thereby being conducive to improving the safety of the medicine and being capable of obtaining a considerable amount of market share in the competition with the original six-ingredient rehmannia pill.

The invention provides a method for improving the soil cadmium removal capability of tobacco by use of a fertilization and harvesting technology. The method comprises the following steps of: transplanting tobacco seedlings to heavy metal cadmium contaminated soil according to a natural growing period of the tobacco seedlings, performing conventional cultivation, applying additional fertilizers during a vigorous growing period, and harvesting tobacco after the tobacco seedlings are mature; and performing conventional cultivation again, and applying additional fertilizers so as to promote growth of regenerated tobacco, so that the cadmium absorption and enrichment capability is improved by virtue of application of additional fertilizers and the growing process of regenerated tobacco, and thus the purpose of removing excessive cadmium in soil is achieved. The tobacco seedlings can grow normally in cadmium contaminated soil without obvious toxic symptoms and influence on tobacco yield, and the tobacco seedlings can be regenerated; furthermore, the overground part of the tobacco is large in biomass, so that a large amount of heavy metal cadmium can be absorbed and accumulated. The method provided by the invention is relatively simple in cultivation and low in management cost; harvesting can be performed twice through once planting; tobacco has relatively high protein content; after being treated, tobacco can serve as a feed, and heavy metals can be prevented from entering a food chain again by virtue of a utilization mode of the tobacco, so that certain economical benefits can be achieved while pollution is treated.

The invention discloses traditional Chinese medicinal oral paste for treating pyretic and toxic symptoms and myocarditis and a preparation method of the traditional Chinese medicinal oral paste. The traditional Chinese medicinal oral paste is prepared from the following raw materials in parts by weight: 15 to 20 parts of purple snowy powder, 25 to 35 parts of coptis chinensis, 15 to 20 parts of scutellaria baicalensis, 25 to 35 parts of cape jasmine, 20 to 30 parts of fructus forsythia, 15 to 20 parts of gypsum fibrosum, 20 to 30 parts of rhizoma anemarrhenae, 25 to 35 parts of compound of glauber-salt and liquorice, 4 to 8 parts of calculus bovis, 15 to 20 parts of rehmannia glutinosa libosch, 15 to 20 parts of radix paeoniae rubra, 20 to 30 parts of moutan bark, 15 to 20 parts of folium isatidis, 15 to 20 parts of isatis root, 25 to 35 parts of radix lithospermi and 15 to 20 parts of rheum officinale. The traditional Chinese medicinal oral paste prepared by preparation method disclosed by the invention really has treatment effects for the pyretic and toxic symptom, the myocarditis, vigorous heat at qi-blood phase symptoms, has the advantages of short treatment period, high cure rate, early recovery, no toxic or side effects, and efficacy of quickly alleviating the symptoms.

The invention discloses a compound traditional Chinese herbal medicinal drink for relieving effects of alcohol. The drink is prepared by blending purified water and extract liquids from the root of kudzu vine, Hovenia duleis Thunb fruit, orange peel, tropical fruit and citric acid. Each 100 ml of the drink comprises the components according to the following ratio: 1-1.5g of the root of kudzu vine, 0.9-1 g of Hovenia duleis Thunb fruit, 0.15-0.25 g of orange peel, 19-20 g of tropical fruit, 0.045-0.055 g of citric acid and 76-80 g of purified water. The drink provided by the invention is prepared by blending pure natural traditional Chinese medicinal materials and a small amount of western medicinal vitamins and adding a proper amount of tropical fruit as a sweetener. The drink has a unique mouthfeel, tastes fresh and cool, and has functions of clearing away heat and toxic materials, enhancing liver detoxification, enzymatic hydrolysis and dieresis, accelerating internal ethanolysis and discharge, increasing blood flow volume in cerebral and coronary vessels and relieving toxic symptom. Drunkenness can be prevented before people drink alcohol; and after people get drunk and then drink the product, drunkenness time can be shortened, discomfortable feelings such as gasteremphraxis and nausea, headache and dizziness, dry mouth and the like which are caused by drunkenness are relieved, increased heart rate and elevation of blood pressure which are caused by excessive drinking are alleviated, and liver injury caused by alcohol can be prevented.

The invention relates to an antidote for preventing and treating livestock aflatoxicosis. The weight ratio of active ingredients, namely, glutathione and berberine, is (1:20)-(20:1). Compared with a common antidote, the livestock feed antidote provided by the invention is simple to prepare and reasonable in compatibility and can remarkably relieve the toxic symptoms of the livestock and is proved by experiments to have a special effect on preventing and treating livestock aflatoxicosis; and without Western medicine components in additives, the antidote avoids toxic and side effects, drug resistance and pollution.

The invention discloses a nux vomica alkaloid patch for treating local myalgia and arthralgia and a preparation method. The patch consists of a medicine storage magazine, a backing layer and an anti-sticking layer, wherein the medicine storage magazine comprises nux vomica total alkaloid with parts of strychnine removed, pressure-sensitive adhesive and transdermal absorption accelerant; the nux vomica has an obvious clinic curative effect on local myalgia and arthralgia caused by rheumatism and traumatic injury; the main active ingredient of the nux vomica is nux vomica total alkaloid, but the strychnine has the disadvantages of big toxin and high ratio in total alkaloid amount, and is likely to generate the toxic symptom when being orally taken; and a poisoning risk due to the damage of patient keratoderma may be caused even if the nux vomica is externally applied. Compared with the nux vomica total alkaloid patch nux vomica alkaloid patch, the external transdermal absorption rate of the strychnine in the patch disclosed by the invention is obviously lowered, and the concentration of the strychnine in the skin and the muscle on the belly pasting position of a mouse is obviously lowered. Compared with the traditional black plaster and adhesive plaster matrix in the traditional Chinese medicine, the patch disclosed by the invention is characterized by having the characteristic that a high-polymer pressure-sensitive adhesive with smaller skin irritation and irritability is selected, and the adhesion can be better. The patch disclosed by the invention has the advantages of high effective ingredient content, big transdermal absorption amount, and high medicine concentration of skin and muscle of the pasted position. The patch production equipment and the technology are mature, and the invention is suitable for large-scale industrial production.

The invention discloses traditional Chinese medicinal powder for oral administration. The traditional Chinese medicinal powder for oral administration consists of the following components in parts byweight: 3-5 parts of radix puerariae, 3-4 parts of seaweed, 5 parts of herba patriniae, 3 parts of honeysuckle flowers, 6 parts of flos chrysanthemi indici, 5-6 parts of herba taraxaci, 5-6 parts of herba violae, 5 parts of radix scrophulariae, 3-5 parts of radix rehmanniae praparata, 3-5 parts of coix seeds, 3-5 parts of radix salviae miltiorrhizae, 3-5 parts of semen platycladi, 3-5 parts of rhizoma gastrodiae, 3-5 parts of semen ziziphi spinosae, 3-5 parts of rhizoma dioscoreae, 3-5 parts of fruit of Chinese wolfberry, 3-5 parts of rhizoma polygonati, 3-5 parts of radix astragali, 3-5 partsof radix polygonati officinalis, 3-5 parts of semen euryales, 3-5 parts of fruit of Chinese magnoliavine, 3-5 parts of radix polygoni multiflori, 3-5 parts of radix angelicae sinensis, 3-5 parts of whorlleaf stonecrop herb, 3-5 parts of radix ophiopogonis and 2 parts of cordyceps sinensis. The traditional Chinese medicinal powder for oral administration provided by the invention can fundamentallysolve pathogenic factors of diseases; and the provided traditional Chinese medicinal powder for oral administration is used for treating toxic symptoms of hyperlipidemia, hypertension, diabetics, cardiovascular and cerebrovascular diseases and stasis in liver and kidney and the traditional Chinese medicinal powder for oral administration is good in curative effect and low in side effects.

The invention discloses a traditional Chinese medicine enteroclysm for treating intestinal obstruction, which comprises raw rheum officinale, mirabilite, talc, Yunnan Baiyao powder, officinal magnolia bark, burdock, raw rhizoma rehmanniae, rhizoma anemarrhenae, white paeony root, liquorice root, radix curcumae and elecampane. The traditional Chinese medicine enteroclysm can ensure that rectum mucosa directly absorbs effective components of the medicine through adopting drip clysis to protect outspread intestinal canal, regulates the functions of all visceral organs under effective function ofthe medicines, reduces endotoxin, inhibits the release of cell inflammatory mediums, resists the pathological states of bowel movement disorder as soon as possible, intestinal tract blood movement disorder, infection toxic symptoms and the like of the intestinal obstruction, and effectively protects the intestinal tract barrier function by using traditional Chinese medicines, thereby relieving the intestinal obstruction. The traditional Chinese medicine enteroclysm has the advantages of remarkable treatment effect, rapid effect taking, short treatment course, easy acceptation, extremely low cost, convenience for processing operation and use, no toxic and side effects, no wound and medicine dependence, treatment of both principal and secondary aspects of the disease, economy and effectiveness, and is especially suitable for being popularized and applied to a base level general hospital.

The invention belongs to the technical field of Chinese herbal medicines, and relates to a traditional Chinese medicine for treating beriberi. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 20-30 parts of cortex phellodendri, 10-15 parts of radix puerariae, 3-5 parts of sweet osmanthus root, 5-10 parts of grapefruit peel, 5-15 parts of radix sophorae flavescentis, 5-10 parts of salicylic acid, 3-5 parts of dried alum, 10-15 parts of radix scutellariae, 5-10 parts of folium artemisiae argyi and 2-8 parts of liquorice root. All the components, which are selected to be used in the traditional Chinese medicine provided by the invention, are in compliance with the provisions of the Drug Administration Law of the People's Republic of China, andnone of the tested animals has any toxic symptom; furthermore, anatomical observations prove that the tested animals have no difference with a control group in the aspects of blood, liver function andhistomorphology of the various organs, so that the traditional Chinese medicine provided by the invention is safe and reliable; the beriberi is treated by means of a combined action of all the Chinese herbs, and the traditional Chinese medicine is non-toxic and harmless to a human body. The traditional Chinese medicine has the advantages of lasting drug effect, no relapse after curing, short treatment course, and the like; the traditional Chinese medicine has a beriberi response rate of 100%.

The invention discloses a garbage bag preventing breeding of winged insects and a production process thereof. The raw material comprises polyethylene, color master batch, hydroquinone and carbamate in the weight ratio of 80-100:10-15:7-10:7-10.The garbage bag preventing breeding of winged insects and the production process thereof have following beneficial effects: carbamate is added to the garbage bag with polyethylene as the main component during production; in the way that such medicament kills target nervous systems with poisons, insects are killed by toxic symptoms such as loss of consciousness, respiratory failure and the like arising from strong inhibition so that growth and reproduction of winged insects are inhibited; and people, free from breeding trouble of winged insects in summer, can conveniently lead their lives.

The invention provides a medicine for treating early trauma poisoning and a preparation method thereof, and relates to new application of a distilled water preparation to the pharmacy field. The medicine for treating early trauma poisoning can be used for realizing that early poisoning toxin at a wounded part in the superficial layer of the skin is eliminated by utilizing the distilled water preparation, and the technical key point adopted by the invention is to carry out low-temperature treatment on distilled water. The medicine disclosed by the invention is mainly applied to elimination of early toxic symptoms, such as the red and swollen on the partial skin, the lumps, the urtication, the stabbing pain and the bruise, generated on the wounded part after virus carriers, such as mosquitoes, bees, snakes, scorpions and sharp tools, sting, bite and puncture the skin of people, and is also mainly applied to prevention and inhibition of virus infection and toxicity diffusion.

The invention discloses a medicine for preventing gelsemium poisoning. An active ingredient of the medicine is N-methyl-D-aspartic acid. The medicine can effectively prevent animal or human gelsemiumpoisoning, especially prevent animal or human poisoning reaction caused by gelsemium alkaloid and gelsenicine in gelsemium; and acute toxicity animal experiments show that advanced administration of the N-methyl-D-aspartic acid (NMDA) can remarkably increase the survival rate of animals absorbing gelsenicine, and the toxic symptom of the animals to the gelsenicine is obviously relieved.

The invention provides a method for improving the soil cadmium removal capability of tobacco by use of a fertilization and harvesting technology. The method comprises the following steps of: transplanting tobacco seedlings to heavy metal cadmium contaminated soil according to a natural growing period of the tobacco seedlings, performing conventional cultivation, applying additional fertilizers during a vigorous growing period, and harvesting tobacco after the tobacco seedlings are mature; and performing conventional cultivation again, and applying additional fertilizers so as to promote growth of regenerated tobacco, so that the cadmium absorption and enrichment capability is improved by virtue of application of additional fertilizers and the growing process of regenerated tobacco, and thus the purpose of removing excessive cadmium in soil is achieved. The tobacco seedlings can grow normally in cadmium contaminated soil without obvious toxic symptoms and influence on tobacco yield, and the tobacco seedlings can be regenerated; furthermore, the overground part of the tobacco is large in biomass, so that a large amount of heavy metal cadmium can be absorbed and accumulated. The method provided by the invention is relatively simple in cultivation and low in management cost; harvesting can be performed twice through once planting; tobacco has relatively high protein content; after being treated, tobacco can serve as a feed, and heavy metals can be prevented from entering a food chain again by virtue of a utilization mode of the tobacco, so that certain economical benefits can be achieved while pollution is treated.

The invention discloses a photosensitive active substance extracted from Bulgaria Inquinans. The photosensitive active substance comprises active ingredients of diisobutyl phthalate causing photosensitive activity toxic reactions. The invention further discloses an extraction method and application of the photosensitive active substance. The photosensitive active ingredients capable of causing toxic symptom aggravation under sunlight are separated from Bulgaria Inquinans sporocarp. The photosensitive active substance can be used for preparing psoriasis drugs and anti-photosensitivity drugs, food and cosmetics and has obvious clinical effect.

The invention relates to a Liuwei Dihuang Pill, which is a famous ancient prescription medicine applied for about millennium, and is a well selling medicine for caring health and strengthening body which is pursued by lots of people and frequently taken for a long time; but Alisma orientale in the Liuwei Dihuang Pill can cause toxic symptoms such as gastroenteritis, nausea, emesis, dizzy symptom, giddiness, bellyache, laxness, limbs weakness, inappetence, pruritus, angioneurotic edema, allergic eruption, and even respiratory paralysis, etc. Ancient and recent medicinal literatures indicate that the Alisma orientale has the effects of dredging the water passage, purging the kidney-fire and causing dizziness, is unsuitable to be taken for long and overdosed, and serious side effects such as nephrotoxicity, acute tubular necrosis, etc., can be caused if the Alisma orientale is taken for a long time. Traditional Chinese medicine cortex lycii radicis is the root bark of medlar that is homology of medicine and food, and has the same effect of purging the kidney-fire with the Alisma orientale in the Liuwei Dihuang Pill. The invention uses the cortex lycii radicis to replace the Alisma orientale to be improved into a new Liuwei Dihuang Pill, thereby not only remaining the enriching yin and nourishing kidney function in Liuwei Dihuang Pill adopting ancient prescription, but also avoiding various side effects caused by using the Alisma orientale, and facilitating to further increase the medicine safety; the new Liuwei Dihuang Pill can acquire considerable number of market shares in the competition with the original Liuwei Dihuang Pill.

The invention discloses a formula for treating uremia and a preparation method. The formula is mainly prepared from, by weight, 8-13 parts of cassia twigs, 10-14 parts of bitter bamboo leaves, 7-15 parts of ramose scouring rush herbs, 6-12 parts of cavalerie fevervine, 4-9 parts of flos rosae rugosae, 6-10 parts of devilpepper roots, 8-12 parts of salvia miltiorrhiza roots, 10-15 parts of stellaria yunnanensis, 7-13 parts of phyllanthus urinaria, 9-12 parts of cymbopogon flowers, 6-11 parts of radix achyranthis bidentatae, 5-10 parts of magnolia coco, 3-8 parts of clovetree twigs and 7-14 parts of gold stargrass herbs. According to the formula for treating the uremia and the preparation method, through functions of integrally regulating and improving the habitus, enhancing the disease preventing and resisting capacities, preserving the residual kidney and the like, blood circulation can be promoted, complete excretion of metabolites such as toxins can be promoted, the toxic symptom of the whole body disappears accordingly, the treatment effect is exact, and the effect is significant.

The invention relates to the technical field of biological medicine, and provides an anti-jelly fish toxin nano antibody KY031, a preparation method and application. The nano antibody is a VHH antibody and has an amino acid sequence shown in SEQ ID NO.1, affinity analysis shows that the nano antibody has good affinity, and small animal experiments prove that after jelly fish toxin is injected into mice in an antibody protection group injected with the nano antibody in advance, no poisoning symptom occurs in the mice, and no toxin lethal condition exists after continuous observation for one month. The nano antibody has an excellent anti-jelly fish toxin effect, has an excellent prevention or treatment effect on jelly fish stings, and has broad clinical application prospects.

The invention provides a toxin protein which is separated and purified from latrodectus tredecimguttatus eggs, wherein the N-terminal sequence is Glu-Ser-Ile-Gln-Thr-Ser-Thr-Tyr-Val-Pro-Asn-Thr-Pro-Asn-Gln-Lys-Phe-Asp-Tyr-Glu-Val-Gly-Lys-Asp-Tyr-, and the molecular weight is 28,690. Intraperitoneal injection can induce a series of toxic symptoms of cockroaches and mouse; and a tetrodotoxin-resistant voltage-gated sodium ion channel on the nerve cell membrane can be inhibited. The invention also provides a purifying method of the toxin protein, which specifically comprises preparation of an egg extract, a molecular sieve chromatography step, an ion-exchange chromatography step and an inverse phase-high performance liquid chromatography step; and by introducing a C4 column with low hydrophobicity for purification, the steps are simple, and the purifying effect is good.