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Medicine for preventing gelsemium poisoning

A technique for poisoning and medicines of geckos, which is applied in the field of medicines, medicines, and medicines for preventing poisoning of geckos, and can solve the problems of no antidote, etc., so as to alleviate the symptoms of toxicity and improve the The effect on survival

Active Publication Date: 2020-12-29
HUNAN AGRICULTURAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present, there is no specific antidote for hook kiss poisoning, and most of them are mainly symptomatic treatment

Method used

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  • Medicine for preventing gelsemium poisoning
  • Medicine for preventing gelsemium poisoning
  • Medicine for preventing gelsemium poisoning

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016]Screening of Drugs for Preventing Mice Gelsostatin Poisoning

[0017]1. Drugs and reagents

[0018]Flumazenil (purity 99%; batch number: M5653-01; AbMole; United States), vitamin B6Injection (batch number: 1903320; Sinopharm Rongsheng Pharmaceutical Co., Ltd., China), MK-801 (purity: >98%; batch number: M7581-01; AbMole; United States), strychnine (purity> 98%; batch number: DST191026-026; Chengdu Munster Biotechnology Co., Ltd.; China), Diazepam

[0019]2. Animals

[0020]Male ICR mice, 18-22g, were provided by Hunan Slack Jingda Experimental Animal Co., Ltd. They were reared at 25°C and room temperature with a light-dark cycle of 12h / 12h, free to eat and drink, and used for formal experiments after 7 days of adaptation to the laboratory.

[0021]3. Method

[0022]Twenty-five mice were randomly divided into 5 groups: Gelsemide group, Flumazenil + Gelsemide group, vitamin B6+Gelmosine group, Strychnine+Gelmosine group, MK-801+Gelmosine group, Diazepam+Gelmosine; 5 animals in each group, labeled...

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Abstract

The invention discloses a medicine for preventing gelsemium poisoning. An active ingredient of the medicine is N-methyl-D-aspartic acid. The medicine can effectively prevent animal or human gelsemiumpoisoning, especially prevent animal or human poisoning reaction caused by gelsemium alkaloid and gelsenicine in gelsemium; and acute toxicity animal experiments show that advanced administration of the N-methyl-D-aspartic acid (NMDA) can remarkably increase the survival rate of animals absorbing gelsenicine, and the toxic symptom of the animals to the gelsenicine is obviously relieved.

Description

Technical field[0001]The invention relates to a medicine, in particular to a medicine for preventing the poisoning of Gelsemium, in particular to a medicine for preventing the poisoning of the alkaloids in Gelsemium, belonging to the technical field of biomedicine.Background technique[0002]Gelsemium is a world-famous poisonous plant. There are three main types of Gelsemium. One is the Asian Gelsemium, also known as Gutweed. It is mainly produced in Fujian, Guangxi, Zhejiang and other places in China, and two North American species, Gelsemium sempervirens and Gelsemium rankinii Small, mainly produced in North America. In China, Gelsemium is often used for skin diseases, neuralgia, cancer, sciatica, etc. Because the dose of Gelsemium is very close to the toxic dose, the clinical use of Gelsemium is limited. Gelsemium is the most toxic alkaloid in Gelsemium, and its intraperitoneal injection of LD50It is 0.185mg / kg, which is a very toxic substance according to the acute toxicity classi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61P39/02
CPCA61K31/198A61K9/0019A61K47/10A61P39/02Y02A50/30
Inventor 刘兆颖孙志良黄思娟左梦婷
Owner HUNAN AGRICULTURAL UNIV
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