Zinc chelate-containing compound vitamin oral nano-emulsion and preparation method for same

A technology for compound vitamins and milk preparations, applied in the directions of medical preparations, drug combinations, and pharmaceutical formulations containing active ingredients, can solve problems such as precipitation, affecting the normal efficacy of products, precipitation, etc., achieving simple process, enhanced antioxidant effect, The effect of promoting absorption

Inactive Publication Date: 2012-06-27
QILU ANIMAL HEALTH PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, products containing chelated zinc, vitamins, selenium and other trace elements produced by the existing nanoemulsion technology have shortcomings such as precipitation and precipitation, which affect the normal function of the product.

Method used

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  • Zinc chelate-containing compound vitamin oral nano-emulsion and preparation method for same
  • Zinc chelate-containing compound vitamin oral nano-emulsion and preparation method for same
  • Zinc chelate-containing compound vitamin oral nano-emulsion and preparation method for same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A compound vitamin oral nanoemulsion preparation containing chelated zinc, the components per liter are as follows:

[0031] Zinc Gluconate 75g, Lysine Hydrochloride 60g, Vitamin A 5g, Vitamin D 3 0.7g, vitamin E 20g, sodium selenite 0.2g, Tween-80 250g, propylene glycol 120g, ethylparaben 0.2g, 2,6-di-tert-butyl-4-methylphenol (BHT) 0.2g , water to 1L.

[0032] The preparation method of the above-mentioned compound vitamin oral nanoemulsion preparation containing chelated zinc comprises the steps:

[0033] (1) Weigh zinc gluconate and lysine hydrochloride in water in proportion, fully stir and dissolve at 40°C, then add sodium selenite, after the solution is clarified, pass through a 5 μm filter membrane, and set aside;

[0034] (2) Weigh VA oil, VD3 oil, and VE oil in proportion and pour them into a dry reaction tank, add preservatives and antioxidants, stir until they are completely dissolved, add emulsifiers and co-emulsifiers, stir until they are evenly clarifie...

Embodiment 2

[0072] A compound vitamin oral nanoemulsion preparation containing chelated zinc, the components per liter are as follows:

[0073] Zinc gluconate 76g, methionine 55g, vitamin A 6g, vitamin D 3 0.6g, vitamin E 15g, sodium selenite 0.3g, Tween-80 280g, polyethylene glycol 100g, ethylparaben 0.2g, BHT 0.2g, dilute water to 1L.

[0074] The preparation method is the same as in Example 1.

[0075] Reserved sample observation test

[0076] Take part of the nanoemulsion prepared in Example 2, divide it into several glass bottles, seal it and place it under the conditions of 0°C, 25°C, and 40°C for 180 days, and take samples for observation every 10 days. The results showed that the nanoemulsion maintained a clear and transparent appearance under the above five temperature conditions, without precipitation, precipitation, opalescence and other phenomena. Observation under a transmission electron microscope shows that the droplets of the nanoemulsion are spherical, uniformly distr...

Embodiment 3

[0080] A compound vitamin oral nanoemulsion preparation containing chelated zinc, the components per liter are as follows:

[0081] Zinc gluconate 78g, methionine 68g, vitamin A 10g, vitamin D 3 0.5g, vitamin E 23g, sodium selenite 0.2g, polyoxyethylene castor oil EL-35 300g, polyethylene glycol 150g, ethylparaben 0.4g, BHT 0.2g, dilute water to 1L.

[0082] The preparation method is the same as in Example 1.

[0083] Reserved sample observation test

[0084] Take part of the nanoemulsion prepared in Example 3, divide it into several glass bottles, seal it and place it under the conditions of 0°C, 25°C, and 40°C for 180 days, and take samples for observation every 10 days. The results show that the nanoemulsion maintains a clear and transparent appearance under the above three temperature conditions, without precipitation, precipitation, opalescence and other phenomena. Observation under a transmission electron microscope shows that the droplets of the nanoemulsion are sph...

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Abstract

The invention relates to a veterinary compound oral nano-emulsion containing zinc chelate, selenium and multivitamins and a preparation method for the same, wherein the veterinary compound oral nano-emulsion comprises the following components: zinc gluconate, a chelant, vitamin A, vitamin D3, vitamin E, sodium selenite, an emulsifier, an emulsifying aid, a preservative, an antioxidant and water. The veterinary compound oral nano-emulsion disclosed by the invention can comprehensively supplement vitamins; moreover, zinc can enhance esterase activity and thus promoting absorption for vitamin A,vitamin D can promote skeletal development, and selenium can promote absorption for vitamin E and enhance the antioxidation of vitamin E; and when toxic symptom appears due to excessive selenium, vitamin E can enhance excretion for selenium and decrease toxicity.

Description

technical field [0001] The invention relates to a veterinary compound oral nanoemulsion preparation containing chelated zinc, selenium and various vitamins and a preparation method thereof, belonging to the technical field of veterinary drug preparations. Background technique [0002] Zinc is an essential trace element for the growth and breeding of livestock and poultry. When the zinc in the feed is deficient or the zinc in the feed is not easily absorbed by the livestock and poultry, the livestock and poultry will have zinc deficiency, resulting in the body of the livestock and poultry becoming thin, the skin thickening, the testes of the breeding stock and poultry obviously shrinking, the sperm decrease, growth, Breeding is affected. Therefore, zinc should be properly supplemented in the process of livestock and poultry breeding. [0003] At present, most zinc supplement products are inorganic zinc, such as zinc sulfate, zinc carbonate, zinc oxide, etc., and the bioavai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/04A61K9/107A61P3/02A61K31/07A61K31/191A61K31/198A61K31/355A61K31/593
Inventor 李成应王海挺吴连勇田玉柱王雅琪
Owner QILU ANIMAL HEALTH PROD
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