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Photosensitive active substance extracted from Bulgaria Inquinans and extraction method of photosensitive active substance

A photosensitive active substance, gel gyro technology, applied in food extraction, food science, drug combination and other directions, to achieve obvious clinical effects

Inactive Publication Date: 2016-07-20
JILIN AGRICULTURAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After searching, there is no report about the photosensitive active substance in the plastic gyro

Method used

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  • Photosensitive active substance extracted from Bulgaria Inquinans and extraction method of photosensitive active substance
  • Photosensitive active substance extracted from Bulgaria Inquinans and extraction method of photosensitive active substance
  • Photosensitive active substance extracted from Bulgaria Inquinans and extraction method of photosensitive active substance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1) Extraction of the crude components of the gelatinous gyro:

[0021] Get the acetone of 1.5kg of the fruiting body of the gelatinous top and add 4.5kg, and reflux extraction for 10 hours to obtain the acetone extract; rotary evaporation to obtain the extractant of the fruiting body of the gelatinous top;

[0022] 2) Dissolve 0.04g of the fruiting body extract of Gelgyro in 0.40mL of polysorbate-80 to make a solution for intragastric administration;

[0023] 3) Take a number of mice, and each mouse is given the gavage solution of step 2), and after 30 minutes, it is placed in the light for 2 hours;

[0024] 4) Remove the ear of the mouse and dry it at low temperature, cut it into pieces and perform Soxhlet extraction, using methanol as the extraction solution; extract three times, each time for 6 hours, combine the extraction solution, spin evaporate to dryness to obtain the extract, and dissolve it in chloroform;

[0025] 5) The chloroform solution in step 4) was sub...

Embodiment 2

[0027] 1) Extraction of the crude components of the gelatinous gyro:

[0028] Take 2.0 kg of the fruiting body of the gyro and add 8.0 kg of acetone, and extract under reflux for 12 hours to obtain an acetone extract; rotary evaporation to obtain the extract of the gyro;

[0029] 2) Dissolve 0.04g of jelly gyro extract in 0.40mL polysorbate-80 to make a solution for intragastric administration;

[0030] 3) Take a number of mice, and each mouse is fed with the solution of step 2), and placed in the light for 3 hours after 30 minutes;

[0031] 4) Remove the ear of the mouse and dry it at low temperature, cut it into pieces and perform Soxhlet extraction, using methanol as the extraction solution; extract three times, each time for 6 hours, combine the extraction solution, spin evaporate to dryness to obtain the extract, and dissolve it in chloroform;

[0032] 5) The chloroform solution in step 4) was subjected to repeated column chromatography separation, the extract was spotte...

Embodiment 3

[0034] 1) Extraction of the crude components of the gelatinous gyro:

[0035] Get 3.0 kg of the fruiting body of the jelly gyro and add 15 kg of acetone, reflux extraction for 10 hours to obtain the acetone extract; rotary evaporation to obtain the jelly gyro extract;

[0036] 2) Dissolve 0.04g of jelly gyro extract in 0.40mL polysorbate-80 to make a solution for intragastric administration;

[0037] 3) Take a number of mice, and each mouse is given the gavage solution of step 2), and placed in the light for 4 hours after 30 minutes;

[0038] 4) Remove the ear of the mouse and dry it at low temperature, cut it into pieces and perform Soxhlet extraction, using methanol as the extraction solution; extract three times, each time for 6 hours, combine the extraction solution, spin evaporate to dryness to obtain the extract, and dissolve it in chloroform;

[0039] 5) The chloroform solution in step 4) was subjected to repeated column chromatography separation, the extract was spott...

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Abstract

The invention discloses a photosensitive active substance extracted from Bulgaria Inquinans. The photosensitive active substance comprises active ingredients of diisobutyl phthalate causing photosensitive activity toxic reactions. The invention further discloses an extraction method and application of the photosensitive active substance. The photosensitive active ingredients capable of causing toxic symptom aggravation under sunlight are separated from Bulgaria Inquinans sporocarp. The photosensitive active substance can be used for preparing psoriasis drugs and anti-photosensitivity drugs, food and cosmetics and has obvious clinical effect.

Description

Technical field: [0001] The invention discloses a photosensitive active substance extracted from plastic gyro, which contains an active ingredient of diisobutyl phthalate that causes photosensitive active poisoning reaction. The invention further discloses an extraction method and application of the photosensitive active substance. It belongs to the technical field of bacterial chemistry. Background technique: [0002] Bulgaria inquinans Fr. belongs to Ascomycetes, Helotiales, Bulgariaceae, Bulgaria Fr. fungi. Glue gyro is rich in various nutrients and is a kind of fungus that people in the mountainous areas of Northeast China eat. However, eating too much or improper handling will often cause skin itching of limbs, burning sensation, swelling of mucous membranes, swelling of lips, accompanied by nausea, vomiting, abdominal pain, diarrhea and atopic dermatitis poisoning symptoms that aggravate after exposure to light . After retrieval, there is no report about the photose...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K36/062A61K8/97A61P17/06A61Q19/00A23L31/00A23L33/10
CPCA23V2002/00A61K8/97A61K36/062A61K41/00A61Q19/00A23V2200/30A23V2250/208A23V2300/14A23V2200/318
Inventor 包海鹰李志军图力古尔杨树东周元飞李昕冉
Owner JILIN AGRICULTURAL UNIV
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