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Preparation method and application of anti-dazzling tablet

A technology of extracting and chuanxiong, applied in the field of preparation of Qingxuan tablets, can solve the problems of large dosage for patients, rough process, affecting clinical application, etc., and achieve the effect of reducing dosage

Inactive Publication Date: 2013-03-27
SHANDONG JIANGHE WETLAND ECOLOGICAL RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report about the use of supercritical and microwave technology in the extraction and preparation of Qingxuan Tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. , seriously affecting the clinical application of this product

Method used

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  • Preparation method and application of anti-dazzling tablet

Examples

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Comparison scheme
Effect test

Embodiment 1

[0025] Take 200g of Rhizoma Chuanxiong, 200g of Angelica dahurica, 100g of Peppermint, 100g of Schizonepetae, and 100g of Gypsum, add Rhizoma Chuanxiong, Mint, and Schizonepeta to a CO2 supercritical extractor, use ethanol as an entrainer, and the entrainer accounts for the volume percentage of the total extraction solvent 4%, extraction pressure 15MPa, temperature 30°C, CO2 flow rate 1m1 / g crude drug·min, extraction time 150min, to obtain a supercritical extract for use; take the rest of the traditional Chinese medicine, crush it, add 2L of 70% ethanol, and put it into a microwave extraction device Microwave extraction was carried out in a medium with an extraction power of 400W, and the extraction was performed twice for 4 minutes each time. The extracts were combined, concentrated, added to a D101 macroporous adsorption resin column, eluted with 50% ethanol, and 5 times the volume of the eluent was collected. Recover ethanol under reduced pressure, concentrate and dry to obt...

Embodiment 2

[0028] Take 200g of Rhizoma Chuanxiong, 200g of Angelica dahurica, 100g of Mint, 100g of Schizonepeta, and 100g of Gypsum, add Chuanxiong, Mint, and Schizonepeta to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction, with an extraction power of 600W, and extracted twice. 8 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain microwave extract , set as...

Embodiment 3

[0031] Take 200g of Rhizoma Chuanxiong, 200g of Angelica dahurica, 100g of Mint, 100g of Schizonepeta, and 100g of Gypsum, add Chuanxiong, Mint, and Schizonepeta to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 500W, and the extraction is performed twice. Combine the extracts for 6 minutes each time, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain microwave extrac...

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Abstract

The invention provides a preparation method of an anti-dazzling tablet which is prepared from crude drugs including 200g of Ligusticum wallichii, 200g of radix angelicae, 100g of mint, 100g of schizonepetaspike and 100g of gypsum through supercritical extraction and microwave extraction, so that the content of ferulic acid is greatly improved. The invention also relates to the application of the anti-dazzling tablet in preparing a medicine for restraining proliferation of human leukemia cell, K562 cell.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Qingxuan tablets. Background technique [0002] Qingxuan tablet is recorded in the standard WS3-B-0836-91 of the Ministry of Health. It is made of 200g of Chuanxiong, 200g of Angelica dahurica, 100g of mint, 100g of Schizonepeta, and 100g of gypsum as raw materials. It can dispel wind and relieve heat. For wind-heat dizziness, migraine headache, stuffy nose and toothache. [0003] In the prior art, there is no report about the use of supercritical and microwave technology in the extraction and preparation of Qingxuan Tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. , Seriously affecting the clinical application of this product. Contents of the invention [0004]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/538A61K9/20A61P11/02A61P1/02A61P25/06A61P25/04A61P35/02A61K33/06
Inventor 不公告发明人
Owner SHANDONG JIANGHE WETLAND ECOLOGICAL RES INST