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Preparation method of Chinese medicinal composition and preparation for preventing and treating male infertility

A technology for male infertility and traditional Chinese medicine preparations, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc. It is fully extracted and other problems to achieve the effect of improving bioavailability, good patient compliance, and convenient taking.

Active Publication Date: 2014-11-05
长春雷允上药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Liuwei Dihuang Pills are crushed into fine powder and used directly as medicine, and then added with refined honey to make pills. However, the medicine has not been extracted, and the active ingredients in the medicine cannot be fully extracted to exert its curative effect.
However, the latest clinical application and pharmacological studies show that the curative effect of this compound Chinese patent medicine needs to be further improved. One of the important reasons is that the active ingredients of each medicinal material in its prescription have not been fully extracted, resulting in the active ingredients of the traditional Chinese medicine preparation The low content directly affects the clinical application and promotion of the compound Chinese patent medicine

Method used

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  • Preparation method of Chinese medicinal composition and preparation for preventing and treating male infertility
  • Preparation method of Chinese medicinal composition and preparation for preventing and treating male infertility
  • Preparation method of Chinese medicinal composition and preparation for preventing and treating male infertility

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Example 1 Preparation of Chinese medicine preparation (oral solution)

[0073] [Prescription] Cuscuta 75g, Ophiopogon japonicus 152g, Epimedium 100g, Deer horn gum 75g

[0074] Rehmannia glutinosa 75g Lycium barbarum 100g Turtle gum 57g Polygonatum 57g

[0075] Ligustrum lucidum 100g Alisma 38g Ginseng 38g Yam 126g

[0076] [Preparation method] The above twelve flavors, tortoise shell glue, deer horn glue, stewed in water. Ginseng 65% (volume) ethanol aqueous solution, reflux extraction twice, the first 2 hours, the second 1.5 hours, combined extracts, filtered, the filtrate recovered ethanol, concentrated to an appropriate amount. Ginseng medicinal dregs and the remaining nine flavors are added to decoct twice, the first time is 2 hours, the second time is 1.5 hours, the decoction is combined, filtered, the filtrate is left standing, and the supernatant is taken with the stewed tortoise shell glue and antlers Ginseng and ginseng extract are mixed evenly, concentrate...

Embodiment 2

[0078] Example 2 Preparation of Chinese medicine preparation (oral solution)

[0079] [Prescription] Cuscuta 60g, Ophiopogon japonicus 100g, Epimedium 70g, Deer horn glue 55g

[0080] Rehmannia glutinosa 100g Lycium barbarum 70g Turtle gum 47g Polygonatum 80g

[0081] Ligustrum lucidum 80g Alisma 30g Ginseng 30g Yam 100g

[0082][Preparation method] The above twelve flavors, tortoise shell glue, deer horn glue, stewed in water. Ginseng 65% (volume) ethanol aqueous solution, reflux extraction twice, the first 2 hours, the second 1.5 hours, combined extracts, filtered, the filtrate recovered ethanol, concentrated to an appropriate amount. Ginseng medicinal dregs and the remaining nine flavors are added to decoct twice, the first time is 2 hours, the second time is 1.5 hours, the decoction is combined, filtered, the filtrate is left standing, and the supernatant is taken with the stewed tortoise shell glue and antlers Ginseng and ginseng extract are mixed evenly, concentrated ...

Embodiment 3

[0084] Example 3 Preparation of Chinese medicine preparation (oral solution)

[0085] [Prescription] Cuscuta 70g Ophiopogon japonicus 150g Epimedium 80g Antler glue 70g

[0086] Rehmannia glutinosa 70g Lycium barbarum 90g Turtle glue 50g Polygonatum 50g

[0087] Ligustrum lucidum 90g Alisma 30g Ginseng 30g Yam 120g

[0088] [Preparation method] The above twelve flavors, tortoise shell glue, deer horn glue, stewed in water. Ginseng 65% (volume) ethanol aqueous solution, reflux extraction twice, the first 2 hours, the second 1.5 hours, combined extracts, filtered, the filtrate recovered ethanol, concentrated to an appropriate amount. Ginseng medicinal dregs and the remaining nine flavors are added to decoct twice, the first time is 2 hours, the second time is 1.5 hours, the decoction is combined, filtered, the filtrate is left standing, and the supernatant is taken with the stewed tortoise shell glue and antlers Ginseng and ginseng extract are mixed evenly, concentrated to a ...

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Abstract

The invention provides a preparation method of a Chinese medicinal composition and a preparation for preventing and treating male infertility. The Chinese medicinal composition and the preparation are prepared from the following drug materials in parts by weight: 50 to 100 parts of Chinese dodder seed, 90 to 175 parts of lilyturf root, 50 to 125 parts of epimedium herb, 40 to 100 parts of deer-horn glue, 40 to 100 parts of prepared rehmannia, 50 to 125 parts of medlar, 25 to 75 parts of tortoise-plastron glue, 25 to 80 parts of sealwort, 40 to 125 parts of glossy privet fruit, 20 to 60 parts of rhizoma alismatis, 10 to 60 parts of ginseng, and 100 to 150 parts of yam. The preparation method comprises the following steps of: (1) stewing the tortoise-plastron glue and the deer-horn glue out of water to a fluid state; (2) adding an ethanol or ethanol aqueous liquid into ginseng to perform reflux extraction; (3) decocting the ginseng dreg with the other 9 drug materials; and (4) uniformly mixing the decoction, the molten tortoise-plastron glue, the molten deer-horn glue and the ginseng extract, and concentrating until the relative density detected by a Westphal bottle method is 1.10. According to the preparation method, the content of effective ingredients of the Chinese medicinal composition and preparation can be remarkably increased, and the curative effect can be remarkably improved.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a preparation method of a traditional Chinese medicine composition and preparation for preventing and / or treating male infertility, in particular to a method for preventing and / or treating low sperm count and decreased sperm motility A preparation method of a traditional Chinese medicine composition and preparation for male infertility. Background technique [0002] Clinical dialectical analysis of traditional Chinese medicine shows that the onset of male infertility caused by decreased sperm count and low sperm motility often begins with insufficient kidney essence. The kidney is the source of storing essence and raising children, and the filling of kidney essence depends on the continuous replenishment of the day after tomorrow. Deficiency of kidney essence refers to the imbalance of yin and yang in the kidney, which further affects the healthy movement of the spleen,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8969A61P15/08A61K35/32A61K35/56A61K35/586
Inventor 邵春杰
Owner 长春雷允上药业有限公司