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Traditional Chinese medicine composition for treating myelofibrosis and preparation method thereof

A technology of myelofibrosis and composition, which is applied in the field of traditional Chinese medicine composition, can solve the problems of lack of effective measures for treating myelofibrosis, and achieve the effect of treating myelofibrosis

Inactive Publication Date: 2013-04-24
合肥海大生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is still a lack of effective measures for the treatment of myelofibrosis. The treatment should be based on the degree of disease of the bone marrow fibrous tissue and the clinical manifestations. The purpose of treatment is to relieve symptoms and prevent the progression of myelofibrosis.

Method used

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  • Traditional Chinese medicine composition for treating myelofibrosis and preparation method thereof
  • Traditional Chinese medicine composition for treating myelofibrosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: Chinese medicine composition granule of the present invention

[0018] Take 180g of white peony root, 120g of oyster, 280g of Ophiopogon japonicus, 120g of Atractylodes macrocephala, 120g of raw land, 180g of heterophylla, 180g of Radix Polygonum, 180g of trichosanthes, 180g of Cistanche, 120g of turtle shell, 180g of red peony, add water and boil twice, the first time for 2 hours , for the second 2 hours, filter, combine the filtrates, let stand for 48 hours, take the supernatant, concentrate under reduced pressure to a thick paste with a relative density of 1.30 (80°C), dry, grind into fine powder, add 200g of lactose, Dextrin 300g, mixed evenly, sieved, wet granulated with 75% ethanol, dried and bagged.

Embodiment 2

[0019] Embodiment 2: Chinese medicine composition capsule of the present invention

[0020] Take 180g of white peony root, 120g of oyster, 280g of Ophiopogon japonicus, 120g of Atractylodes macrocephala, 120g of raw land, 180g of heterophylla, 180g of Radix Polygonum, 180g of trichosanthes, 180g of Cistanche, 120g of turtle shell, 180g of red peony, add water and boil twice, the first time for 2 hours , for the second 2 hours, filter, combine the filtrates, let stand for 48 hours, take the supernatant, concentrate under reduced pressure to a thick paste with a relative density of 1.30 (80°C), dry, grind into fine powder, add 250g of dextrin , mix well, and put into empty capsules.

Embodiment 3

[0021] Embodiment 3: Chinese medicine composition tablet of the present invention

[0022] Take 180g of white peony root, 120g of oyster, 280g of Ophiopogon japonicus, 120g of Atractylodes macrocephala, 120g of raw land, 180g of heterophylla, 180g of Radix Polygonum, 180g of trichosanthes, 180g of Cistanche, 120g of turtle shell, 180g of red peony, add water and boil twice, the first time for 2 hours , for the second 2 hours, filter, combine the filtrates, let stand for 48 hours, take the supernatant, concentrate under reduced pressure to a thick paste with a relative density of 1.30 (80°C), dry, grind into fine powder, add 200g of starch, 100 g of microcrystalline cellulose, mixed evenly, sieved, wet granulated with 75% ethanol, compressed into tablets and coated.

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Abstract

The invention discloses a traditional Chinese medicine composition for treating myelofibrosis. The composition of the traditional Chinese medicine comprises white paeony roots, oysters, radix ophiopogonis, white atractylodes rhizome, radix rehmanniae, radix pseudostellariae, multiflower knotweed roots, radix trichosanthis, desertliving cistanche, turtle shells, red paeony roots or acceptable carriers in pharmacy. The invention further discloses a preparation method of the composition of the traditional Chinese medicine. The composition of the traditional Chinese medicine has the effects of softening hardness to dissipate stagnation, invigorating the circulation of blood, regulating the stagnation of qi and the like, is used for treating myelofibrosis clinically, has a good curative effect, and is free from toxic and side effects.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating myelofibrosis and a preparation method thereof. Background technique [0002] Myelofibrosis refers to the pathological state in which bone marrow hematopoietic tissue is replaced by fibrous tissue, affecting hematopoietic function, accompanied by extramedullary hematopoiesis in spleen, liver and other organs. The pathogenesis of this disease has not yet been elucidated. It is speculated that the proliferation of fibroblasts in this disease is a reactive and secondary lesion with increased sensitivity to cytokines, while hematopoietic cells undergo clonal or neoplastic hyperplasia. [0003] Most of myelofibrosis occurs between 50-70 years old, with slow onset, mostly asymptomatic or atypical symptoms in the early stage, and about 30% of patients are only diagnosed with high metabolic manifestations such as fatigue...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61P7/06A61P7/00
Inventor 徐旭东方明
Owner 合肥海大生物医药科技有限公司
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