Transdermal sustained-release drug delivery system and preparation and application method thereof

A technology of drug delivery system and application method, applied in the field of percutaneous drug delivery sustained-release system, can solve the problems of inability to continue drug use, skin impermeability, contact dermatitis, etc., achieving no skin irritation and allergic reaction, and good affinity , the effect of large drug loading

Inactive Publication Date: 2013-05-22
TONGDE HOSPITAL OF ZHEJIANG PROVINCE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the transdermal drug delivery system is a hot spot in modern pharmacy research, it also has its shortcomings. For example, due to the impermeability of the skin, only some active drugs are suitable for transdermal drug delivery. Contact dermatitis occurs at the

Method used

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  • Transdermal sustained-release drug delivery system and preparation and application method thereof
  • Transdermal sustained-release drug delivery system and preparation and application method thereof
  • Transdermal sustained-release drug delivery system and preparation and application method thereof

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Embodiment Construction

[0048] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0049] The embodiment of the present invention provides a transdermal drug delivery system based on a water-soluble polymer material. The basic formula of the drug delivery system is prepared by the following excipients in parts by weight:

[0050] 2 parts of polyvinyl alcohol, 1.5 parts of sodium polyacrylate, 2.5 parts of gelatin,

[0051] 1 part of sodium carboxymethylcellulose, 18 parts of sorbitol, 10 parts of glycerin,

[0052] 50 parts of water, 0.5 parts of castor oil, 0.05 parts of azone

[0053] The embodiment of the present invention also provides the formulation application of a trans...

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Abstract

The invention provides a formula of a transdermal sustained-release drug delivery system employing water-soluble polymer material as a substrate, a preparation method of the system, and an application of the preparation, wherein the substrate is formed by the mixing of polyvinyl alcohol, gelatin, sodium carboxymethylcellulose, sorbitol, glycerin, sodium polyacrylate, castor oil and water. The substrate is large in drug loading capacity, good in affinity with various drugs including extracts of traditional Chinese medicines and chemical drugs, good in transdermal effect as the drug is sustainedly released in a transdermal manner, air-permeable, high in comfort level while being applied on skin, basically free of skin irritation and hypersensitivity reactions, and can be repeatedly used, thus being an ideal transdermal drug delivery platform. And various kinds of sustained-release transdermal delivery preparation can be prepared by combining with various drugs.

Description

technical field [0001] The invention belongs to the technical field of transdermal sustained-release drug delivery systems, and in particular relates to a preparation method and formulation application of a transdermal sustained-release drug delivery system with a water-soluble polymer material as a matrix. Background technique [0002] Transdermal drug delivery system (transdermal drug delivery system, TDDS) refers to a controlled release drug system that can promote a therapeutic amount of drugs to pass through the skin and enter the systemic circulation to exert a systemic effect. Difficulties in gastrointestinal absorption caused by drug interactions; can avoid the first-pass effect; can also avoid the inconvenience caused by injection administration; prolong the curative effect after a single dose; control the short half-life through drug storage and controlled release characteristics The treatment time of the drug; and can be torn off at any time to stop the drug; and ...

Claims

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Application Information

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IPC IPC(8): A61K36/00A61K36/889A61K36/896A61K36/30A61K38/18A61K9/70A61K47/44
Inventor 俞忠明寿旦董宇郭巧英高家鉴章建民吴人杰王绪平
Owner TONGDE HOSPITAL OF ZHEJIANG PROVINCE
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