Transdermal sustained-release drug delivery system and preparation and application method thereof

Abstract

The invention provides a formula of a transdermal sustained-release drug delivery system employing water-soluble polymer material as a substrate, a preparation method of the system, and an application of the preparation, wherein the substrate is formed by the mixing of polyvinyl alcohol, gelatin, sodium carboxymethylcellulose, sorbitol, glycerin, sodium polyacrylate, castor oil and water. The substrate is large in drug loading capacity, good in affinity with various drugs including extracts of traditional Chinese medicines and chemical drugs, good in transdermal effect as the drug is sustainedly released in a transdermal manner, air-permeable, high in comfort level while being applied on skin, basically free of skin irritation and hypersensitivity reactions, and can be repeatedly used, thus being an ideal transdermal drug delivery platform. And various kinds of sustained-release transdermal delivery preparation can be prepared by combining with various drugs.

Description

technical field [0001] The invention belongs to the technical field of transdermal sustained-release drug delivery systems, and in particular relates to a preparation method and formulation application of a transdermal sustained-release drug delivery system with a water-soluble polymer material as a matrix. Background technique [0002] Transdermal drug delivery system (transdermal drug delivery system, TDDS) refers to a controlled release drug system that can promote a therapeutic amount of drugs to pass through the skin and enter the systemic circulation to exert a systemic effect. Difficulties in gastrointestinal absorption caused by drug interactions; can avoid the first-pass effect; can also avoid the inconvenience caused by injection administration; prolong the curative effect after a single dose; control the short half-life through drug storage and controlled release characteristics The treatment time of the drug; and can be torn off at any time to stop the drug; and ...

AI Technical Summary

Problems solved by technology

Although the transdermal drug delivery system is a hot spot in modern pharmacy research, it also has its shortcomings. For example, due to the impermeability of the skin, only some active drugs are suitable for transdermal drug delivery. Contact dermatitis occurs at the site of application, and the drug cannot be continued. Therefore, when conducting research on the transdermal drug delivery system, various relevant factors should be considered comprehensively, and appropriate drugs and excipients can be selected to complete the study.

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