Externally used traditional Chinese medicine composition and cataplasm for treating lobular hyperplasia of mammary gland, and preparation methods thereof
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A technique of mammary gland lobular hyperplasia and Babu ointment is applied in the field of traditional Chinese medicine, and achieves the effects of relieving premenstrual breast pain, reasonable preparation process and large drug loading capacity
Active Publication Date: 2012-10-03
ZHEJIANG ACAD OF TRADITIONAL CHINESE MEDICINE
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Commonly used Chinese patent medicines include: Rukang Capsules, Rupixiao Tablets (capsules), Xiaojindan, Xiaoyao Powder, etc. Currently, there is no external preparation of traditional Chinese medicine that has obtained the production number of the State Food and Drug Administration for clinical application
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Embodiment 1
[0050] 1) Take 250g of qualified epimedium and 250g of acute seed, add 4000g of water, soak for 0.5h, decoct and extract for 2 hours, filter; add 3000g of water to the filter residue, decoct and extract for 1 hour, filter; combine the filtrates twice , concentrated under reduced pressure to 476ml (relative density at 40°C is 1.05), cooled to room temperature, and slowly added 816ml of medicinal ethanol with a mass concentration of 95% under stirring to make the alcohol content 60%, fully stirred, and stood overnight After filtration, the filtrate is recovered under reduced pressure until it has no alcohol smell, and continues to concentrate in a water bath to about 475ml (relative density at 40°C is 1.05) liquid medicine, and set aside;
[0051] 2) Take 100g of cloves, 4g of natrium, and 50g of frankincense that have passed the inspection, crush them, pass through a No. 3 sieve, and put them in a supercritical fluid extraction device. CO 2 Carry out supercritical extraction, ...
Embodiment 2
[0057] 1) Take 25Kg of qualified Epimedium and 25Kg of acute seed, add 400Kg of water, soak for 0.5h, decoct and extract for 2 hours, filter; add 300Kg of water to the filter residue, decoct and extract for 1 hour, filter; combine the filtrates twice , concentrated under reduced pressure to 48 L (relative density at 40°C is 1.05), cooled to room temperature, and slowly added 81.6 L of medicinal ethanol with a mass concentration of 95% under stirring to make the alcohol content 60%, fully stirred, and statically Leave it overnight and then filter, and the filtrate is decompressed to recover the solvent until it has no alcohol smell, and then continue to concentrate in a water bath to about 47.6 L (relative density at 40°C is 1.05) liquid medicine, and set aside;
[0058] 2) Take 10Kg of cloves, 400g of natrium, and 5Kg of frankincense that have passed the inspection, crush them, pass through a No. 3 sieve, and put them in a supercritical fluid extraction device. CO 2 Carry out...
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Abstract
The invention relates to an externally used traditional Chinese medicine composition and cataplasm for treating lobular hyperplasia of mammary gland, and preparation methods thereof, belonging to the field of traditional Chinese medicine. The externally used traditional Chinese medicine composition for treating lobular hyperplasia of mammary gland comprises the following components in parts: 10-15 parts of epimedium, 2-8 parts of clove, 0.1-0.3 part of artificial musk, 0.1-0.5 part of dragons blood, 0.1-0.4 part of salmiacum, 10-15 parts of garden balsam, 2-5 parts of frankincense and 0.1-0.5part of camphor. The prescription has compatibility and efficacies of penetrating through the skin into the interior, promoting flow of qi and blood circulation, removing obstruction in channels and detoxifying, removing blood stasis and resolving phlegm, and softening and resolving hard mass to remove breast lumps. The preparation method adopts advanced extraction processes such as decoction extraction, CO2 supercritical extraction and the like to extract the active components, and adopts superfine comminution to treat trace noble medicinal materials which are used as medicines directly; anda water soluble high molecular material is adopted to prepare the externally used cataplasm which is advanced in dosage form, high in drug loading rate, convenient in use and highly comfortable in application. The externally used preparation is used for treating breast lobular hyperplasia and is capable of preventing and alleviating breast distention and pain before menstruation.
Description
technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicinal composition for treating mammary gland lobular hyperplasia, a cataplasm ointment and a preparation method. Background technique [0002] Mammary gland hyperplasia is a benign proliferative disease of breast tissue, neither inflammation nor tumor. In pathological form, it includes chronic cystic hyperplasia and lobular hyperplasia, so it is also called breast cystic hyperplasia or chronic breast cystic breast disease, commonly known as "breast lobular hyperplasia", which belongs to the category of "breast addiction" in traditional Chinese medicine. The disease is a common disease in women, mostly occurs in 30 to 50 years old, women aged 50 to 60 can also develop the disease. According to the statistics of Maternal and Child Health in China, the incidence of breast disease has reached 32.4% of the diseases of women of childbearing age, am...
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