Whitening composition and product thereof for multi-mechanism inhibition of tyrosinase activity

Abstract

The invention provides a whitening composition inhibiting tyrosinase activities with multiple mechanisms and products of the composition, which relate to the field of chemicals for daily use. The whitening composition contains three active matters for inhibiting a tyrosinase active mechanism, and the three active matters include an active matter with competitive inhibition action, an active matter with noncompetitive inhibition action and an active matter with linear mixing competitive inhibition action. According to the invention, three inhibition mechanisms are used to obtain the novel inhibition composition, thus improving the enzyme inhibition efficacy of whitening effective substances and combinations, improving the biological effect of whitening, and reducing potential application irritation; the whitening composition is wide in coverage and relatively high in applicability, and has good whitening and freckle removing effects; and the whitening composition can be designed into essence, day cream, night cream, facial masks, facial cleansing milk and like products among cosmetic products.

Description

technical field [0001] The present invention relates to a whitening composition, in particular to a whitening combination optimized for the different inhibition mechanisms of melanin production rate-limiting enzyme-tyrosinase, including competitive, non-competitive and linear mixed competitive inhibition mechanisms things. Background technique [0002] Asian women pay special attention to the beauty of fair skin. In response to this demand, a large number of cosmetic companies and researchers have invested manpower and material resources in the research and development of active ingredients for skin whitening. At present, many skin whitening agents have come out, such as the early pure chemical hydroquinone, the medium-term fruit acid and tissue extract placenta cream, and the recent natural plant extracts such as arbutin, Vc derivatives and licorice extract. The advent of these skin whitening agents has met the needs of consumers to a certain extent and stimulated the dev...

AI Technical Summary

Problems solved by technology

[0004] Although the above studies can inhibit tyrosinase activity, the effect in the actual product failed to meet expectations, and there are several main shortcomings: 1) The mechanism of inhibiting tyrosinase activity has not been further studied, and whitening has not yet been studied 2) Even if some whitening agents or combination components have known mechanisms of tyrosinase inhibition, they have not targeted various inhibition mechanisms such as competitive inhibition, non-competitive 3) Failed to screen whitening effective substances or combinations for different inhibition mechanisms, and make corresponding enzyme activity inhibition tests

Existing whitening agents or combinations targeting tyrosinase inhibition often only consider the competitive inhibitory effect on tyrosinase, which has a single target, so there are insufficient efficacy in actual use and the required dosage of whitening agents is large cause stimulation and other deficiencies

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