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Application of volatile oil of Uyghur medicine Tumor Nigella in preparation of medicine for treating chronic obstructive pulmonary disease

A technology of Nigella sativa and chronic obstructive disease, which is applied in the field of NGS volatile oil medicine, can solve problems such as COPD effects that have not been reported, achieve inhibition of pulmonary bronchial smooth muscle M choline receptors, stabilize anti-chronic inflammation, and prevent the formation of lung Effects of bullae and emphysema

Active Publication Date: 2015-10-28
中国人民解放军新疆军区联勤部药品仪器检验所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are a small number of in vitro studies reported abroad that sativa seeds can improve respiratory system disorders, but no research data on the effect of NGS on COPD has been reported.

Method used

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  • Application of volatile oil of Uyghur medicine Tumor Nigella in preparation of medicine for treating chronic obstructive pulmonary disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1, the application of the Uyghur medicine Nigella cuminum volatile oil in the preparation of medicaments for treating chronic obstructive pulmonary disease.

[0021] According to actual needs, the application of the above-mentioned Uyghur medicine Nigella cuminum volatile oil in the preparation of drugs for the treatment of chronic obstructive pulmonary disease can be further optimized or / and improved:

Embodiment 2

[0022] Example 2, as a preference of the above example, the mass percentage of NGS volatile oil contains m-cymene 41% to 63%, α-pinene 8% to 14%, and thymoquinone 3.5% to 5.8%.

Embodiment 3

[0023] Example 3, as a preference of the above examples, the mass percentage of NGS volatile oil contains m-cymene 61.48%, α-pinene 12.95%, and thymoquinone 3.7 3%.

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Abstract

The invention relates to the technical field of NGS volatile oil medicine, specifically to an application of a Uighur drug nigella glandulifera preyn seed volatile oil in chronic obstructive pulmonary disease drug preparation. With the NGS volatile oil, a stable anti-chronic inflammation effect is provided for chronic bronchitis caused by chronic obstructive pulmonary diseases, lung bronchial spasm symptoms caused by chronic obstructive pulmonary diseases can be effectively improved, and generation of pulmonary bulla and emphysema can be prevented. The action mechanism relates to functions of lung bronchial smooth muscle M cholinergic receptor inhibition, and lung bronchial tissue inflammatory cell and inflammatory cytokine reduction, wherein the action mechanism is described in home and abroad researches at the first time.

Description

technical field [0001] The invention relates to the technical field of NGS volatile oil medicine, and relates to the application of the volatile oil of Nigella cumulus of Uyghur medicine in the preparation of a medicine for treating chronic obstructive pulmonary disease. Background technique [0002] Chronic obstructive pulmonary disease (COPD) is a general term for chronic airway obstructive diseases, mainly referring to chronic bronchitis and emphysema with irreversible airway obstruction. COPD patients have a poor prognosis and eventually die of respiratory failure and pulmonary diseases, which is the fourth leading cause of human death. The pathogenesis of COPD is mainly the chronic inflammation of the pulmonary bronchi, which leads to the persistence of bronchospasm, hyperactivity of cathepsin, and long-term damage to the structure of the pulmonary bronchi. There are currently no drugs that can reverse the progressive decline in lung function. Chemical drugs for the s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61P11/00A61P29/00C11B9/02
Inventor 耿东升张宏涛张文斌
Owner 中国人民解放军新疆军区联勤部药品仪器检验所
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