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Extracts of vietnamese sophora root and application thereof

A kind of extract, the technology of mountain bean, which is applied in the field of mountain bean root extract, can solve the problems such as the application of petroleum ether extract of mountain bean root that has not been seen

Active Publication Date: 2013-09-18
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] No see bean root petroleum ether extract and its application in anti-dementia

Method used

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  • Extracts of vietnamese sophora root and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Embodiment 1: the petroleum ether extract of mountain bean root

[0066] The roots and rhizomes of the bean root are crushed into a coarse powder with a particle size of 500 μm. Weigh 500 grams of the bean root coarse powder, soak it with 1500 ml of petroleum ether for 24 hours, and then percolate with petroleum ether until the color of the extract is light. Collect the petroleum ether leachate about 5 times the amount of medicinal material (ie 2500ml), concentrate the petroleum ether to dryness under reduced pressure, and obtain 2.67g of petroleum ether extract (yield: 0.53%).

Embodiment 2

[0067] Embodiment 2: the ethanol extract and the ethyl acetate extract of mountain bean root

[0068] The roots and rhizomes of Bean root are crushed into coarse powder with a particle size of 300 μm. Weigh 500 grams of Bean root coarse powder, soak it with 1500 ml of petroleum ether for 24 hours, then percolate with petroleum ether until the color of the extract is light, collect Petroleum ether leachate is about 5 times the amount of medicinal materials (ie 2500g), recover the residue, evaporate the petroleum ether in the residue, extract the residue twice with 80% ethanol with a concentration of 1500ml, each time for 2 hours, combine the two extracts, reduce Concentrate under pressure until there is no alcohol smell to obtain an ethanol concentrate, extract it with an equal volume of ethyl acetate, pour off the upper layer, and concentrate to dryness to obtain 1.02 g of ethyl acetate extract (yield: 0.20%); release the lower layer , concentrated to dryness to obtain 51.88g ...

Embodiment 3

[0069] Embodiment 3: the ethyl acetate extract of mountain bean root

[0070] 1. The root of the mountain bean root is crushed into a coarse powder, and the particle size is 850 μm. Take 500 g of the root of the mountain bean root and soak it in petroleum ether with a volume (2500 ml) of 5 times the weight of the root of the mountain bean root for 36 hours. Ether percolation until the color of the percolation liquid becomes lighter (obtaining 3500ml of petroleum ether percolation liquid), and recovering the residue;

[0071] 2. Evaporate the solvent in the residue, then extract the residue twice with 3500ml of 90% ethanol, the extraction time is 3 hours and 2 hours, combine the extracts, then concentrate until there is no alcohol smell, and then mix with an equal volume of Extract with ethyl acetate, collect the supernatant, and evaporate to dryness to obtain 1.70 g of ethyl acetate extract (yield: 0.34%).

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Abstract

The invention relates to extracts of vietnamese sophora root and application thereof and in particular relates to a petroleum ether extract, an ethanol extract and an ethyl acetate extract of vietnamese sophora root. Through experiments, the petroleum ether extract, the ethanol extract and the ethyl acetate extract of vietnamese sophora root can be used for preventing and treating the Alzheimer's disease and have better effects than the prior art.

Description

technical field [0001] The present invention relates to the extract of the root of the mountain bean, in particular to the petroleum ether extract, the extract of ethanol, the extract of ethyl acetate and the application thereof. Background technique [0002] Sophora tonkinensis is the dried root and rhizome of Sophora tonkinensis Gagnep., a leguminous plant. It has the effects of clearing heat and detoxifying, reducing swelling and relieving throat. For accumulation of fire and poison, sore throat, gingival swelling and pain. [0003] Modern pharmacological research shows that mountain bean root has the following effects: [0004] 1. Anti-pathogenic microorganism effect: Experiments have shown that the bean root has an inhibitory effect on Staphylococcus aureus, Epidermophyton flocculus and Candida albicans, and has an efficient antibacterial effect on Mycobacterium tuberculosis. 2. Anti-tumor: Shandou root has a significant effect on malignant tumors, has few side effect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489A61P25/28
Inventor 陈士林黄林芳刘艾林王冬梅
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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