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Astragalus membranaceus powder medicament as well as extraction method and use thereof

An extraction method and technology of astragalus powder are applied in the field of traditional Chinese medicine and natural medicine, and can solve the problems of single drug extraction, high resource waste, low extraction efficiency, etc., and achieve the effects of good effect, simple preparation method and avoidance of resource waste.

Inactive Publication Date: 2013-09-18
QIANNIANJIAN MEDICINE RES & DEV CO LTD BAOTOU CITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing extraction of effective parts of traditional Chinese medicines for treating diabetes is generally a single drug extraction, which not only has low extraction efficiency, but also has high waste of resources.

Method used

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  • Astragalus membranaceus powder medicament as well as extraction method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] After the raw materials of Astragalus powder are mixed in proportion, the total weight is 100 g, crushed to 10-120 mesh, the first time adding 60%-95% ethanol which is 6-10 times the weight of Astragalus powder and soaked for 2-3 hours, slightly Keep it boiling for 1-2 hours, then use 6-10 times the amount of 20%-60% alcohol for the second time, keep it warm for 1-2 hours under boiling, extract 1-5 times, and combine the extracts. Pass through a 300-400 mesh filter bag while it is hot to obtain a clarified filtrate. Pass the filtrate through a three-section high-pressure series resin equipped with PIPO-00 macroporous resin, HPD-500 macroporous resin and strong acid cation exchange resin. When the sample loading is raw material (weight g): resin (weight g) = 1:1, the sample loading is completed, and the flow rate is 1 / 10BV / min. First use 10~15BV of water to elute the three-section series resin, then use 6~10 BV of 80% ethanol to elute the PIPO-00 macroporous resin colum...

Embodiment 2

[0025] After mixing the raw materials of Astragalus Powder in appropriate proportions, the total weight is 1 kg, and crushed to 10-120 meshes. For the first time, add 60%-95% ethanol which is 6-10 times the weight of Astragalus Powder and soak for 2-3 hours. Incubate for 1-2 h in a slightly boiling state. For the second time, use 6-10 times the amount of 20%-60% alcohol and heat for 1-2 h in a slightly boiling state, extract 1-5 times, and combine the extracts. Pass through a 300-400 mesh filter bag while it is hot to obtain a clarified filtrate. Pass the filtrate through a three-section high-pressure series resin equipped with PIPO-00 macroporous resin, HPD-500 macroporous resin and strong acid cation exchange resin. When the sample loading is raw material (weight g): resin (weight g) = 1:1, the sample loading is completed, and the flow rate is 1 / 10BV / min. First use 10~15BV water to elute the three-section series resin, then use 6~10BV 80% ethanol to elute the PIPO-00 macrop...

Embodiment 3

[0027] After mixing the raw materials of Astragalus Powder in appropriate proportions, the total weight is 10 kg, and crushed to 10-120 meshes. For the first time, add 60%-95% ethanol which is 6-10 times the weight of Astragalus Powder and soak for 2-3 hours. Incubate for 1-2 h in a slightly boiling state. For the second time, use 6-10 times the amount of 20%-60% alcohol and heat for 1-2 h in a slightly boiling state, extract 1-5 times, and combine the extracts. Pass through a 300-400 mesh filter bag while it is hot to obtain a clarified filtrate. Pass the filtrate through a three-section high-pressure series resin equipped with PIPO-00 macroporous resin, HPD-500 macroporous resin and strong acid cation exchange resin. When the sample loading is raw material (weight g): resin (weight g) = 1:1, the sample loading is completed, and the flow rate is 1 / 10BV / min. First use 10~15BV water to elute the three-section series resin, then use 6~10BV 80% ethanol to elute the PIPO-00 macro...

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Abstract

The invention relates to an astragalus membranaceus powder medicament as well as an extraction method and use thereof. The astragalus membranaceus powder medicament is prepared from the raw materials in parts by weight: 1-100 parts of astragalus membranaceus, 1-100 parts of root of kudzu vine, and 1-100 parts of root bark of white mulberry. The prepared medicament contains isoprenylated flavonoids, general flavones except for isopentene group, total saponins, total alkaloids and total polysaccharides, and can be used for prevention and treatment of endocrine system diseases, and used for prevention and treatment of the type-2 diabetes mellitus. The astragalus membranaceus powder medicament has the advantages that the medicament is a pure Chinese medicine preparation, less in dosage when being used for prevention and treatment of the type-2 diabetes mellitus and good in effect. By adopting the method disclosed by the invention, the flavones ingredients, namely the isoprenylated flavonoids, the general flavones except for isopentene group, the total saponins, the total alkaloids and the total polysaccharides in the astragalus membranaceus powder are synchronously obtained; resource waste caused by single extraction is effectively avoided; the comprehensive utilization rate of the compound Chinese medicine astragalus membranaceus powder is increased; the deep processing cost is reduced; and meanwhile, the preparation method is simple, convenient, practical, and easy to achieve industrial production.

Description

technical field [0001] The invention relates to an astragalus powder medicine, an extraction method and application, and belongs to the technical field of traditional Chinese medicine and natural medicine. Background technique [0002] Diabetes mellitus (DM for short) usually refers to type 2 diabetes mellitus (T2DM), accounting for more than 90% of the total number of DM, and is one of the three non-communicable diseases with the highest morbidity and mortality in the world. The prevalence of diabetes worldwide is currently on the rise. Especially in China, India, Africa and other developing countries, the rise is most obvious. According to the latest data from the World Health Organization, there are 246 million diabetic patients in the world, and the number of diabetic patients in China is 39.8 million, which is second only to India (40.9 million) in the world. ) is the country with the second largest incidence of diabetes. Experts predict that by 2025, the total number...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/605A61P3/10A61P5/00
Inventor 李卫民段志涛
Owner QIANNIANJIAN MEDICINE RES & DEV CO LTD BAOTOU CITY
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