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A kind of pharmaceutical composition of frovatriptan and preparation method thereof

A technology of frotriptan succinate and a composition, which is applied in the field of solid preparations of frotriptan succinate, and can solve problems such as unreported reports and research and development reports and the like

Inactive Publication Date: 2016-01-13
DIHON PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no market for this product in China, and there are no reports of application and research and development.

Method used

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  • A kind of pharmaceutical composition of frovatriptan and preparation method thereof
  • A kind of pharmaceutical composition of frovatriptan and preparation method thereof
  • A kind of pharmaceutical composition of frovatriptan and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] formula:

[0015]

[0016] Preparation Process:

[0017] Weigh the raw and auxiliary materials according to the formula ratio, combine the raw materials and auxiliary materials and pass through a 60-mesh sieve until they are evenly mixed. The powder is directly compressed into frovatriptan succinate tablets with a tablet weight of 140 mg and a tablet diameter of 7 mm (frovatriptan succinate capsules can also be directly filled into No. 3 capsules).

Embodiment 2

[0019] formula:

[0020]

[0021] Preparation Process:

[0022] Weigh the raw and auxiliary materials according to the formula ratio, combine the raw materials and auxiliary materials and pass through a 60-mesh sieve until they are evenly mixed. The powder is directly compressed into frovatriptan succinate tablets with a tablet weight of 140 mg and a tablet diameter of 7 mm (frovatriptan succinate capsules can also be directly filled into No. 3 capsules).

Embodiment 3

[0024] formula:

[0025]

[0026] Preparation Process:

[0027] Weigh the raw and auxiliary materials according to the formula ratio, combine the raw materials and auxiliary materials and pass through a 60-mesh sieve until they are evenly mixed. The powder is directly compressed into frovatriptan succinate tablets with a tablet weight of 140 mg and a tablet diameter of 7 mm (frovatriptan succinate capsules can also be directly filled into No. 3 capsules).

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PUM

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Abstract

The invention discloses a medicine composition with which frovatriptan succinate can maintain stable. The composition comprises: a, an active component frovatriptan succinate; and b, other common solid preparation auxiliary materials. The other solid preparation forming auxiliary materials are two or more selected from lactose, starch, hydroxypropyl methyl cellulose, povidone copolymer, high-substituted hydroxypropyl cellulose, low-substituted hydroxypropyl cellulose, cross-linked povidone, magnesium stearate, talcum powder, and the like. The invention also discloses a preparation method of the medicine composition.

Description

technical field [0001] The invention relates to a pharmaceutical composition of frovatriptan and a preparation method thereof. In particular, it relates to a solid preparation of frovatriptan succinate, such as tablets, capsules and granules, and a preparation method thereof. Background technique [0002] Migraine is a vascular headache characterized by recurrent hemi- or bilateral headaches. It is a common clinical chronic neurovascular disease with a prevalence rate of 3.3% to 32.6% for women and 0.7% to 16.1% for men. %. Migraine has a great impact on the quality of life. More than 1 / 2 of patients' headaches can affect work or study, and nearly 1 / 3 of patients can be absent from work or school due to headaches. Recurrent migraine attacks can also lead to cognitive decline, mainly speech decline. In addition to the damage caused by the disease itself, migraine can further lead to other damage. For example, migraine is an independent risk factor for stroke. Migraine can...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/403A61K47/38A61P25/06
Inventor 肖碧容史炎高春生
Owner DIHON PHARMA GROUP