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Preparation method of medicine or health-care product for treating xerophthalmia and use of medicine or health-care product

A health care product and a technology for dry eye, which is applied in the field of preparation of drugs for the treatment of dry eye, and can solve the problems of abnormal tear dynamics, abnormal meibomian glands, and rapid evaporation of tears on the surface of the eyeball.

Inactive Publication Date: 2013-11-20
HEBEI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no unified dry eye classification standard in the world. According to the etiology and pathogenesis of dry eye in my country, the classification standard of dry eye in my country is based on the lack of tear components and abnormal tear dynamics in different dry eye patients. Category: (1) Evaporation excessive type: This type of dry eye is mainly due to the abnormality (atrophy, blockage or inflammation) of the meibomian glands in the upper and lower eyelids, resulting in a decrease in the amount of lipid secreted by the meibomian glands or inflammation of the meibomian glands. Rapid evaporation of tears from the surface of the eyeball

Method used

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  • Preparation method of medicine or health-care product for treating xerophthalmia and use of medicine or health-care product
  • Preparation method of medicine or health-care product for treating xerophthalmia and use of medicine or health-care product
  • Preparation method of medicine or health-care product for treating xerophthalmia and use of medicine or health-care product

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] In order to facilitate the application of the medicament of the present invention in the treatment of dry eye, the steps of extracting its active ingredients are as follows:

[0097] (1) Weigh 1000g of light fermented soya bean, pulverize into a coarse powder, degrease by pressing, and use the dregs for subsequent use;

[0098] (2) Step (1) obtained medicinal residues are extracted 3 times with 70% ethanol 7000ml, each time for 2 hours, the extracts are combined, the ethanol is recovered, concentrated to a solution of 0.2g crude drug / ml, and set aside;

[0099] (3) The solution obtained in step (2) is purified by the macroporous adsorption resin of the HPD500 model of 1000ml, first eluted with 5000ml of water, and the eluent is discarded, then eluted with 70% ethanol of 10000ml, and collected and eluted Liquid, recovery of ethanol, concentration, that is, the active ingredient.

Embodiment 2

[0101] In order to facilitate the application of the medicament of the present invention for treating dry eye, it is made into a capsule by the following steps:

[0102] (1) Weigh 1000g of light tempeh, grind it into a coarse powder, degrease it by pressing, and keep the dregs for later use;

[0103] (2) Step (1) obtained medicinal residues are extracted 3 times with 6000ml of 70% ethanol, each time for 2 hours, the extracts are combined, the ethanol is recovered, concentrated to a solution of 0.15g crude drug / ml, and set aside;

[0104] (3) step (2) gained solution, adopt the macroporous adsorption resin of the HPD500 model of 1000ml to carry out purification, first use the water eluting of 5000ml, eluent is discarded, then elute with 70% ethanol of 10000ml, reclaim ethanol, Dried to obtain a dry ointment for subsequent use;

[0105] (4) Grind the dry paste obtained in step (3), pass through an 80-mesh sieve, add starch in an amount equal to the weight of the dry paste, mix,...

Embodiment 3

[0107] In order to facilitate the application of the medicament of the present invention in the treatment of dry eye, it is made into a tablet by the following steps

[0108] (1) Weigh 1000g of light fermented soya bean, crush it into a coarse powder, degrease with petroleum ether extraction method with a boiling point of 60-90°C, and prepare the dregs for later use;

[0109] (2) Step (1) obtained medicinal residues are extracted 2 times with 80% ethanol 8000ml, each time for 2 hours, the extracts are combined, the ethanol is recovered, concentrated to a solution of 0.3g crude drug / ml, and set aside;

[0110] (3) step (2) gained solution, adopt the HPD100 model macroporous adsorption resin of 1000ml to purify, first use the water elution of 10000ml, eluent is discarded, then use the 80% ethanol elution of 15000ml, reclaim ethanol concentration , dry, get a dry paste for later use;

[0111] (4) Grinding the dry paste obtained in step (3), passing through an 80-mesh sieve, addi...

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Abstract

The invention belongs to the field of pharmaceutical manufacturing and application, and in particular discloses a preparation method of a medicine or a health-care product for treating xerophthalmia and a novel use of the medicine or health-care product. Pharmacological experiments verify that the medicine or health-care product can increase secretion of tear of a mouse with xerophthalmia and has a better effect on treatment of xerophthalmia or insufficient secretion of tear. A fermented soybean medicinal material in the medicine or the health-care product belongs to a traditional Chinese medicine as medicine and food, so that the medicinal material can be prepared into the medicine, health-care product or the like for treating xerophthalmia.

Description

technical field [0001] The invention relates to a preparation method and application of a medicine for treating dry eye syndrome, and belongs to the field of medicine manufacture and application. Background technique [0002] Dry eye is one of the most common ophthalmic diseases. It is a series of syndromes caused by the imbalance of tear quality and quantity after the secretion of water quality, mucus and lipid on the surface of the eyeball due to various reasons. factor disease. [0003] At present, there is no unified dry eye classification standard in the world. According to the etiology and pathogenesis of dry eye in my country, the classification standard of dry eye in my country is based on the lack of tear components and abnormal tear dynamics in different dry eye patients. Category: (1) Evaporation excessive type: This type of dry eye is mainly due to the abnormality (atrophy, blockage or inflammation) of the meibomian glands in the upper and lower eyelids, resultin...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61P27/02
Inventor 王鑫国牛丽颖刘敏彦崔力剑刘姣李向军
Owner HEBEI MEDICAL UNIVERSITY
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