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Novel application of methylene blue to post-anesthesia awakening

A technology of methylene blue and sobriety, which is applied in the new application field of methylene blue to promote sobriety after anesthesia, and can solve problems such as uncertain effects and troubles of rescue methods

Active Publication Date: 2013-12-04
INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, almost all anesthetics will cause anesthesia overdose, and the occurrence of anesthesia overdose often indicates the specificity of the individual, resulting in uncertain effects of general rescue methods. Therefore, anesthesia overdose is still an important problem that plagues animal experiments and clinical research

Method used

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  • Novel application of methylene blue to post-anesthesia awakening
  • Novel application of methylene blue to post-anesthesia awakening

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Intraperitoneal injection of methylene blue can significantly accelerate the awakening of anesthetized mice

[0031] Material

[0032] 1. Experimental Kunming mice, SPF grade, provided by the Experimental Animal Center of the Academy of Military Medical Sciences. Males, weighing 18-22 grams, were reared in a 12-hour light / 12-hour dark environment, drank water normally at room temperature (23-26°C, RH35-50%), and fed special mouse feed provided by the Experimental Animal Center of the Academy of Military Medical Sciences.

[0033] 2. Pentobarbital sodium dry powder (Sigma-Aldrich, St.Louis, MO), 1% dissolved in normal saline, preserved.

[0034] 3. Methylene blue solution (Sigma-Aldrich, St. Louis, MO), the concentration is 1%, and the brown bottle is protected from light at 4°C.

[0035] 4. A timer accurate to the second.

[0036] anaesthetization

[0037] According to the experimental animal operation recommendations, Kunming mice were anesthetized by int...

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PUM

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Abstract

The invention relates to novel application of methylene blue to post-anesthesia awakening. The novel application is characterized in that after an animal is completely anesthetized, a certain dose of the methylene blue can be injected to the animal, so that awakening of the animal can be accelerated, the anesthesia time is shortened, and overdose anesthesia can be reduced to a certain extent; the novel application of the methylene blue is beneficial to relieving and resisting the overdose anesthesia by the aid of the methylene blue in animal experiments and clinical application; the experimental animal is anesthetized by the aid of pentobarbital sodium with certain concentration, then methylene blue solution with certain concentration is injected to the completely anesthetized animal, and the concentration of the methylene blue solution is lower than a toxic dose of the methylene blue; then the awakening time of the animal is observed, and an awakening effect of the methylene blue is judged after the awakening effect of the methylene blue is compared with an awakening effect of normal saline; as shown by experiment results, the required time for awakening the animal after the animal is anesthetized by the aid of the pentobarbital sodium can be obviously shortened by the aid of the methylene blue solution, an awakening latency stage can be shortened, and the overdose anesthesia can be reduced. The novel application of the methylene blue has the advantages that a safe, convenient and speedy awakening measure is hopefully provided for clinical application, and possible injury to patients due to the overdose anesthesia can be reduced.

Description

technical field [0001] The invention relates to a new application of methylene blue for promoting wakefulness after anesthesia. After the animal is completely anesthetized, injecting a certain dose of methylene blue can speed up the awakening of the animal, shorten the anesthesia time, and reduce the occurrence of anesthesia overdose to a certain extent. This new use of methylene blue will help methylene blue alleviate and fight against anesthesia overdose in animal experiments and clinically. Background technique [0002] Methylene blue (methylene blue), also known as methylene blue, methylene blue, methylene blue, methylene blue, royal blue, methylene blue, Swiss blue (Swiss blue), the international non-proprietary drug (INN) name is methylthioninium chloride. It is an aromatic heterocyclic compound. The aqueous solution of methylene blue is blue in an oxidative environment, but it will be reduced to a colorless form when it encounters reducing agents such as zinc and am...

Claims

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Application Information

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IPC IPC(8): A61K31/5415A61P39/00A23L1/30A23L33/10
Inventor 赵永岐范明刘淑红吴燕吴丽颖房涛葛学铭赵晓雨
Owner INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
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