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Organic metal platinum compound with anti-cancer effect, and synthesis method thereof

An organometallic compound technology, applied in the field of organometallic platinum compounds and their synthesis, can solve the problems of drug resistance, reduced drug efficacy and anticancer spectrum, etc., achieves easy preparation method, easy industrial promotion and application, and inhibits cancer. The effect of cell proliferation

Inactive Publication Date: 2013-12-11
DEZHOU UNIV
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Problems solved by technology

[0003] At present, the biggest problem in the clinical application of platinum-based anticancer drugs is drug resistance. Many patients develop congenital or acquired resistance to platinum-based anticancer drugs, which seriously reduces the efficacy and anti-cancer spectrum of drugs.

Method used

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  • Organic metal platinum compound with anti-cancer effect, and synthesis method thereof
  • Organic metal platinum compound with anti-cancer effect, and synthesis method thereof
  • Organic metal platinum compound with anti-cancer effect, and synthesis method thereof

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Embodiment Construction

[0011] (1) The organic ligand N,N'-bis(2-dimethylamino-ethyl)oxalamide (L) with N and O heteroatoms was synthesized according to the existing method;

[0012] (2) The organic ligand L and K 2 PtCl 6 React at 30 degrees Celsius for 6 hours, let stand at room temperature, filter, and naturally volatilize at room temperature to obtain the corresponding crystals. The synthetic route is as follows:

[0013]

[0014] The crystal structure was analyzed by X-ray diffraction, and the results showed that the crystal structure can be expressed as [Pt(II)Cl 6 ] 2- · L 2+ .

[0015] Furthermore, the effects of the above organometallic platinum compounds with clear structures on human lung adenocarcinoma cell A549, mouse leukemia cell line P388, human cervical cancer cell Hela, human breast cancer cell MCF-7 and liver cancer cell Hep G2 were studied. Half inhibitory concentration (IC 50 ),like figure 1 shown in the table.

[0016] The results showed that the two compounds had dif...

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Abstract

The present invention discloses an organic metal platinum compound with a cancer cell proliferation inhibition effect. The compound is synthesized through the following steps: synthesizing an organic ligand N,N'-bis(2-dimethylamino-ethyl)-oxamide L having N and O heteroatoms according the existing literature method, carrying out a reaction of the organic ligand and K2PtCl6 for 6 h at a temperature of 30 DEG C, standing to achieve a room temperature, filtering, and naturally volatilizing at the room temperature to obtain the corresponding crystal [Pt(II)Cl6]<2->.L<2+>, wherein the crystal has a significant cancer cell proliferation inhibition effect, and can be adopted as a novel platinum anticancer drug to be used. In addition, the preparation method is easy to operate, and is easy to industrially promote and apply.

Description

technical field [0001] The invention relates to a synthesis method of a compound, in particular to an organometallic platinum compound with anticancer effect and a synthesis method thereof. Background technique [0002] Since the discovery of cisplatin's anticancer activity in 1967, the application and research of platinum-based metal anticancer drugs have developed rapidly. Today, cisplatin and carboplatin have become indispensable drugs in cancer chemotherapy. In 1995, the World Health Organization evaluated nearly 100 kinds of anticancer drugs in the world, and the comprehensive evaluation scores of cisplatin, such as curative effect and market, ranked first and ranked second. According to statistics, cisplatin-based or combined with cisplatin accounts for 70%-80% of all chemotherapy regimens in my country's anticancer chemotherapy regimens. [0003] At present, the biggest problem in the clinical application of platinum anticancer drugs is drug resistance. Many patient...

Claims

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Application Information

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IPC IPC(8): C07F15/00A61P35/00A61P35/02
Inventor 宋玉兰
Owner DEZHOU UNIV
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