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Application of ginseng total sub-glycoside combination, ginseng prosapogenin or ginseng protosaponin in preparation of medicines for treating Meniere's syndrome

Active Publication Date: 2013-12-25
SHANGHAI HONGYITANG BIOPHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The evaluation of domestic and foreign research data in recent years shows that buflomedil has the risk of adverse reactions in the nervous system and cardiovascular system, and such risks exceed its limited clinical treatment benefits

Method used

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  • Application of ginseng total sub-glycoside combination, ginseng prosapogenin or ginseng protosaponin in preparation of medicines for treating Meniere's syndrome
  • Application of ginseng total sub-glycoside combination, ginseng prosapogenin or ginseng protosaponin in preparation of medicines for treating Meniere's syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Take 10 kg of Radix Notoginseng decoction pieces, and extract 3 times with 70% ethanol under reflux, each time with 5 times the amount of solvent, each time for 3 hours. The combined extracts were concentrated under reduced pressure. Add an equal volume of 99% glacial acetic acid to the concentrated solution, and hydrolyze at 97-99°C for 5 hours. Add an equal volume of water to the hydrolyzate and pass it through a D10l macroporous resin column. After loading the sample, eluted with water until nearly colorless, then eluted with 0.5% sodium hydroxide, eluted with water until neutral, eluted with 20% ethanol, and finally eluted with 70% ethanol, collected the 70% ethanol eluate, Concentrate under reduced pressure to a fluid extract, and vacuum-dry at 70°C to obtain 0.56 kg of total ginsenoside extract.

[0047] Measure the content of each active ingredient with high pressure liquid chromatography: 20-(S)-Rg3 is 9.0%, 20-(R)-Ra3 is 9.0%, 20-(S)-Rg2 is 2.1%, 20- (R)-Rg2...

Embodiment 2

[0049] Take 10 kg of ginseng decoction pieces, and extract 3 times with 70% ethanol under reflux, each time with 5 times the amount of solvent, each time for 3 hours. The combined extracts were concentrated under reduced pressure. Add an equal volume of 99% glacial acetic acid to the concentrated solution, and hydrolyze at 97-99°C for 5 hours. Add an equal volume of water to the hydrolyzate, and pass through the DM2 macroporous resin column. After the sample is loaded, it is eluted with water until it is nearly colorless, then eluted with 3.5% sodium hydroxide, then eluted with water until neutral, then eluted with 20% ethanol, and finally eluted with 75% ethanol, and the 75% ethanol eluate is collected. Concentrate under reduced pressure to liquid extract, and dry in vacuum at 70°C to obtain 0.38 kg of total ginsenoside extract.

[0050] Measure the content of each active ingredient with high pressure liquid chromatography: 20-(S)-Rg3 is 5.7%, 20-(R)-Rg3 is 5.7%, 20-(S)-Rg2...

Embodiment 3

[0052] Take 10 kg of American ginseng decoction pieces, and extract 3 times with 70% ethanol under reflux, each time with 5 times the amount of solvent, each time for 3 hours. The combined extracts were concentrated under reduced pressure. Add an equal volume of 99% glacial acetic acid to the concentrated solution, and hydrolyze at 97-99°C for 5 hours. Add an equal volume of water to the hydrolyzate and pass it through a D10l macroporous resin column. After loading the sample, eluted with water until nearly colorless, then eluted with 0.5% sodium hydroxide, eluted with water until neutral, eluted with 20% ethanol, and finally eluted with 70% ethanol, collected the 70% ethanol eluate, Concentrate under reduced pressure to a fluid extract, and vacuum-dry at 70°C to obtain 0.55 kg of total ginsenoside extract.

[0053] Measure the content of each active ingredient with high pressure liquid chromatography: 20-(S)-Rg3 is 8.7%, 20-(R)-Rg3 is 8.7%, 20-(S)-Rg2 is 3.4%, 20-(Rg )-Rg2...

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Abstract

The invention relates to the field of medicines, and particularly relates to an application of a ginseng total sub-glycoside combination, ginseng prosapogenin or ginseng protosaponin in the preparation of medicines for treating tinnitus, dizziness and Meniere's syndrome. Plants for preparing the ginseng total sub-glycoside medicine combination are panax plants, and are preferably selected from at least one of ginseng, pseudo-ginseng, panax japonicus, American gingseng and Korean ginseng. The ginseng total sub-glycoside combination is a mixture of ginsenoside partially hydrolyzed and a degradation product, namely secondary saponin, part of glycosyl of which is removed. The physiological activity of the ginseng total sub-glycoside combination is greatly enhanced, and the ginseng total sub-glycoside combination has the physiological activities such as blood vessel expansion, heart dynamic enhancement and platelet aggregation inhibition. The ginseng total sub-glycoside combination, the ginseng prosapogenin or the ginseng protosaponin is used for treating the Meniere's syndrome, is definite in curative effect and has high effective rate, small individual difference and high safety without side effects.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of a total ginsenoside composition, ginsenoside or ginsenoside in the preparation of medicines for treating tinnitus, vertigo and Meniere's syndrome. Background technique [0002] Meniere's disease, also known as Meniere's syndrome, is an inner ear disease of unknown cause, characterized by labyrinthine hydrops. In 1938, Hallpike and Cairns reported that the main pathological change of the disease was membranous labyrinthine hydrops, and this finding has been confirmed by many scholars. However, how membranous labyrinthine hydrops are produced is difficult to explain clearly. The currently known causes include the following factors: various infectious factors (bacteria, viruses, etc.), injuries (including mechanical injuries or acoustic injuries), otosclerosis, syphilis, genetic factors, allergies, tumors, leukemia and autoimmune diseases, etc. . The clinical manifestat...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K31/575A61K31/704A61P1/08A61P27/16
Inventor 高尚先
Owner SHANGHAI HONGYITANG BIOPHARM CO LTD
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