Dihydrobenzofuran derivative as well as preparation method, intermediate and application thereof

Abstract

The invention discloses a dihydrobenzofuran derivative as shown by formula I in the specification, a tautomer, a racemate, an enantiomer, a diastereoisomer and a hydrate thereof, or a pharmaceutically acceptable salt or medicament precursor thereof. The invention also discloses a preparation method, an intermediate and an application of the dihydrobenzofuran derivative. The dihydrobenzofuran derivative disclosed by the invention is a very effective agonist to GPR40.

Description

technical field [0001] The present invention specifically relates to dihydrobenzofuran derivatives, their preparation methods, intermediates and their applications. Background technique [0002] Insulin is a hormone secreted by islet β cells in the human pancreas. It has many important physiological functions, the most important of which is to lower blood sugar and regulate sugar metabolism. It can promote the utilization of sugar in human tissues, convert glucose into glycogen and fat, and inhibit gluconeogenesis. It also regulates the metabolism of fat and protein and is a very important bioactive substance in the human body. Insulin secretion defects and insulin resistance (IR) are the basic links and characteristics of the pathogenesis of type II diabetes. Research results show that the early metabolic characteristics of type II diabetes patients are insufficient insulin action and dysfunction of islet β cells (J Clin. Invest. 1998, 101, 86-96.). Obesity and hyperlipi...

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Problems solved by technology

[0008] 虽然目前已有专利公开了作为GPR40受体激动剂或拮抗剂的化合物及其制备方法,如WO2003099793,WO2004022551,WO2004041266,WO2004106276,WO2005063725,WO2005063729,WO2005087710,WO2005095338,WO2006011615,WO2007013689,WO2005086661,WO2006127503,WO2008065409, WO2007033002, WO2007106469, WO2008030520, WO2008030618, WO

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