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A compound combination with synergistic free radical scavenging effect

A technology of free radicals and compositions, applied in the fields of compound screening, application, food science, etc., can solve the problem of unclear active ingredients and mechanism of action

Active Publication Date: 2015-12-30
SHANDONG AGRICULTURAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In TCM treatment, doctors often use the two medicines in pairs based on experience to achieve better efficacy, but the active ingredients and mechanism of action behind this synergy are still unclear

Method used

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  • A compound combination with synergistic free radical scavenging effect
  • A compound combination with synergistic free radical scavenging effect
  • A compound combination with synergistic free radical scavenging effect

Examples

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Embodiment Construction

[0017] (1) Screening of solvent extracts of Radix Astragali and Cimicifuga to scavenge DPPH free radicals synergistically: Astragalus powder was extracted with ethanol with a volume fraction of 85% to 95% under reflux, and then concentrated to extract by rotary evaporation. Add deionized water of the same quality as the extract to make a suspension, place it in a separatory funnel, and sequentially extract it step by step with petroleum ether, chloroform, ethyl acetate, and n-butanol, and collect the solvent extracts and concentrate them into the extract Finally, the petroleum ether extract, chloroform extract, ethyl acetate extract and n-butanol extract of Astragalus were obtained respectively. Cimicifuga medicinal powder is also extracted and extracted by the above method to obtain Cimicifuga petroleum ether extract, chloroform extract, ethyl acetate extract and n-butanol extract. Through the determination of the DPPH free radical scavenging ability of the 4 extracts of Astr...

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Abstract

The invention relates to a compound combination with an effect of synergistically scavenging radicals. Active trace detection is carried out by adopting a 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging assay; the synergistic effects (combination coefficient, CI) of two groups of antioxidant ingredients are evaluated by adopting a dose-effect analysis method on the basis of a median effect principle; a group of compounds for synergistically scavenging the radicals, namely calycosin and isoferulic acid are screened from astragalus membranaceus and cimicifugae foetidae; methanol solutions of the calycosin and the isoferulic acid are combined according to different dose ratios (3:1, 2:1, 1:1, 1:2, or 1:3), so as to determine the DPPH radical scavenging capacity. Thus, the calycosin and the isoferulic acid display the best synergistic effect under the condition that the dose ratio is 1:1.

Description

(1) Technical field [0001] The invention relates to a compound combination with a synergistic effect of scavenging free radicals, belonging to the field of health food development. (2) Background technology [0002] The formation of an aging population society has increased the incidence of aging-related diseases such as cardiovascular disease, Parkinson's disease, Alzheimer's disease, etc., and some chronic diseases such as cancer that are prone to occur in the elderly have also shown a younger trend in recent years. and the people have caused a huge medical burden. Studies have found that preventing and improving sub-health status is an important way to prevent and alleviate the above diseases, and dietary regulation is one of the more important and economical methods. At present, many studies have confirmed that oxidative stress is directly or indirectly closely related to various diseases, and stress-mediated oxidative stress is also considered to be the initial stage o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L1/29A23L33/00
CPCA23L33/00A23V2002/00G01N33/90G01N2500/20A23V2200/30A23V2250/21A23V2250/2116A23V2300/14A23V2300/50
Inventor 李大鹏王菲
Owner SHANDONG AGRICULTURAL UNIVERSITY
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