Antibacterial compound containing quinoline or pyrazole heterocycle rhodanine structure

Abstract

The invention provides an antibacterial compound containing a quinoline or pyrazole heterocycle rhodanine structure and a synthetic method thereof. The antibacterial compound containing the quinoline or pyrazole heterocycle rhodanine structure has a broad antibacterial spectrum and obvious antibacterial activity on gram-positive bacteria, and minimum inhibitory concentration is 1 microgram / ml, thus the antibacterial compound containing the quinoline or pyrazole heterocycle rhodanine structure has the potential to be prepared into an antibacterial agent. The invention provides a lead compound for developing a new antibacterial agent, the synthetic method of the antibacterial compound is simple and reasonable, and production cost is low.

Description

technical field [0001] The invention provides a class of novel compounds with obvious antibacterial activity. The compound exhibits remarkable antibacterial activity against Gram-positive bacteria, and the minimum inhibitory concentration reaches 1 μg / mL. Background technique [0002] Despite the rapid progress of science and technology, the rapid development of antibacterial drugs, more than 200 kinds have been used clinically, and the lives of countless patients have been cured and saved. However, the treatment of infectious diseases is still a serious problem left to the medical field today. question. [0003] This is mainly because the current antibacterial drugs have the following problems: [0004] Antimicrobial resistance. Although many antimicrobial agents are used clinically and have achieved good curative effects, the long-term non-standard use of antibiotics has led to the emergence of various drug-resistant bacteria, which has increased the difficulty of clinic...

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