Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of preparation method and application of lotus root extract

A technology of hair lotus and extract, which is applied in the field of biomedicine to achieve the effect of low production cost and easy operation of the preparation process

Inactive Publication Date: 2015-09-02
SHANDONG RES INST OF TUMOUR PREVENTION TREATMENT
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The above-mentioned documents and patents, etc., have not yet seen the report of using high-speed countercurrent chromatography, polyamide and other chromatographic purification techniques to prepare the extract of lotus root

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of preparation method and application of lotus root extract
  • A kind of preparation method and application of lotus root extract
  • A kind of preparation method and application of lotus root extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1: Preparation of the lotus extract and monomer compound

[0031] (1) 30kg of lotus root, use 65% ethanol as the solvent, extract by warm soaking at 25°C, the number of extractions is 3 times, each extraction time is 24 hours, and the amount of solvent used each time is 23 times the weight of the medicinal material; filter , combining the extracts, recovering ethanol, concentrating, and drying to obtain the lotus root extract A;

[0032] (2) Dissolve the lotus root extract A obtained in step (1) with 15 times the amount of water, filter to obtain liquid A and precipitate A; use high-speed countercurrent chromatography (HSCCC) to dissolve the precipitate A with petroleum ether -Ethyl acetate-methanol-water (2:2:1:1) is the solvent system, separation and purification are carried out, the solvent is recovered, concentrated and dried, and the lotus root extract B is obtained;

[0033] (3) Pass the drug solution A obtained in step (2) through a polyamide column, elu...

Embodiment 2

[0037] Embodiment 2: Preparation of lotus root extract and monomer compound

[0038] (1) 10 kg of lotus root, use ethanol with a concentration of 65% as a solvent, and extract by warm soaking at 10°C, the number of extractions is 5 times, each extraction time is 48 hours, and the amount of each solvent is 25 times the weight of the medicinal material; filter , combining the extracts, recovering ethanol, concentrating, and drying to obtain the lotus root extract A;

[0039] (2) Dissolve the lotus extract A obtained in step (1) with 20 times the amount of water, and filter to obtain liquid A and precipitation A; use high-speed countercurrent chromatography (HSCCC) to dissolve precipitation A with petroleum ether -Ethyl acetate-methanol-water (2:2:1:1) is the solvent system, separation and purification are carried out, the solvent is recovered, concentrated and dried, and the lotus root extract B is obtained;

[0040] (3) Pass the drug solution A obtained in step (2) through a p...

Embodiment 3

[0044] Embodiment 3: Preparation of lotus root extract and monomer compound

[0045] (1) 10kg of hair lotus, use 65% ethanol as solvent, and extract by warm soaking at 35°C, the number of extractions is 1 time, each extraction time is 12 hours, and the amount of each solvent is 21 times the weight of the medicinal material; filter , combining the extracts, recovering ethanol, concentrating, and drying to obtain the lotus root extract A;

[0046] (2) Dissolve the lotus root extract A obtained in step (1) with 5 times the amount of water, and filter to obtain the medicinal solution A and precipitation A; the precipitation A is mixed with petroleum ether by high-speed countercurrent chromatography (HSCCC). -Ethyl acetate-methanol-water (2:2:1:1) is the solvent system, separation and purification are carried out, the solvent is recovered, concentrated and dried, and the lotus root extract B is obtained;

[0047] (3) Pass the drug solution A obtained in step (2) through a polyamid...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a preparation method for a Picris japonica extract and application thereof. The preparation method includes: extracting Picris japonica, conducting high speed counter current chromatography, polyamide and other chromatography purification to obtain a Picris japonica extract B and a Picris japonica extract C, and mixing the Picris japonica extract B with the Picris japonica extract C in certain proportion so as to obtain the Picris japonica extract, which can be combined with a pharmaceutically acceptable carrier or other suitable excipients so as to be prepared into oral medication dosage forms according to conventional methods. The Picris japonica extract can be used for preparing drugs for prevention and treatment of diabetes.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to a preparation method and application of an extract of Chinese medicinal materials, in particular to a preparation method of a lotus root extract and its application in the preparation of drugs for preventing and treating diabetes. Background technique [0002] With the aging of the world's population, diabetes has become a common and frequently-occurring disease, and its incidence is on the rise in industrialized countries. According to statistics, there are about 150 million diabetic patients in the world, 80% of which are non-insulin-dependent diabetes (type 2), of which there are about 30 million in my country. The number of deaths caused by diabetes complications ranks third after cardiovascular and cerebrovascular diseases and cancer in developed countries, which has attracted great attention from all over the world, and researches on the pathogenesis and drug prevention and treatme...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61K9/20A61K9/16A61K9/48A61P3/10
Inventor 孙燕来张毅李焱李健宁
Owner SHANDONG RES INST OF TUMOUR PREVENTION TREATMENT
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com