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A kind of irbesartan hydrochlorothiazide tablet and preparation method thereof

A technology of chlorothiazide tablets and hydrochlorothiazide, which is applied in the direction of pill delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve problems such as poor fluidity and sticky punching, improve solubility, avoid sticky punching, and avoid content The effect of substandard uniformity

Active Publication Date: 2015-08-19
HEBEI LONGHAI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by this invention is to overcome the defects of the prior art and provide a kind of irbesartan hydrochlorothiazide tablet, which has the advantages of high dissolution rate of irbesartan and hydrochlorothiazide and good uniformity of hydrochlorothiazide content; the present invention further The preparation method of the tablet is provided, and the method can solve the problems of electrostatic adsorption, agglomeration, poor fluidity, and sticking of irbesartan and hydrochlorothiazide

Method used

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  • A kind of irbesartan hydrochlorothiazide tablet and preparation method thereof
  • A kind of irbesartan hydrochlorothiazide tablet and preparation method thereof
  • A kind of irbesartan hydrochlorothiazide tablet and preparation method thereof

Examples

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Effect test

Embodiment 1

[0021] Embodiment 1 prepares the irbesartan hydrochlorothiazide tablet of the present invention

[0022] prescription:

[0023]

[0024] Preparation:

[0025] (1) Preparation of medicinal premix: Take inulin lauryl carbamate and heat it in a water bath at 80°C to make it molten, add irbesartan and hydrochlorothiazide, stir well, and put it in the refrigerator at -15°C to solidify. Pulverize, place in a vacuum drier at room temperature and dry to constant weight, pulverize and pass through an 80-mesh sieve to obtain a medicinal premix;

[0026] (2) Compressed tablets: Mix the medicinal premix with methylcellulose and microcrystalline cellulose under high shear for 1.5 minutes, spray water on the mixture for 3 minutes, add AEROPERL300Pharma and mix for 3 minutes to obtain dry granules. Finally, magnesium stearate was added and mixed for 30 seconds, and the tablet was obtained.

Embodiment 2

[0027] Embodiment 2 prepares the irbesartan hydrochlorothiazide tablet of the present invention

[0028] prescription:

[0029]

[0030] Preparation:

[0031] (1) Preparation of medicinal premix: Take inulin lauryl carbamate and heat it in a water bath at 80°C to make it molten, add irbesartan and hydrochlorothiazide, stir well, and put it in the refrigerator at -15°C to solidify. Pulverize, place in a vacuum drier at room temperature and dry to constant weight, pulverize and pass through an 80-mesh sieve to obtain a medicinal premix;

[0032] (2) Compressed tablets: Mix the medicinal premix with methylcellulose and microcrystalline cellulose under high shear for 1.5 minutes, spray water on the mixture for 3 minutes, add AEROPERL300Pharma and mix for 3 minutes to obtain dry granules. Finally, magnesium stearate was added and mixed for 30 seconds, and the tablet was obtained.

Embodiment 3

[0033] Embodiment 3 prepares irbesartan hydrochlorothiazide tablet of the present invention

[0034] prescription:

[0035]

[0036] Preparation:

[0037] (1) Preparation of medicinal premix: Take inulin lauryl carbamate and heat it in a water bath at 80°C to make it molten, add irbesartan and hydrochlorothiazide, stir well, and put it in the refrigerator at -15°C to solidify. Pulverize, place in a vacuum drier at room temperature and dry to constant weight, pulverize and pass through an 80-mesh sieve to obtain a medicinal premix;

[0038] (2) Compressed tablets: Mix the medicinal premix with methylcellulose and microcrystalline cellulose under high shear for 1.5 minutes, spray water on the mixture for 3 minutes, add AEROPERL300Pharma and mix for 3 minutes to obtain dry granules. Finally, magnesium stearate was added and mixed for 30 seconds, and the tablet was obtained.

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Abstract

The invention relates to an irbesartan and hydrochlorothiazide tablet and a preparation method thereof, belonging to the technical field of drug preparations. The tablet contains an irbesartan and hydrochlorothiazide medicinal premix, wherein the irbesartan and hydrochlorothiazide medicinal premix is formed by irbesartan, hydrochlorothiazide and inulin lauryl carbamate, wherein the ratio of the total weight of irbesartan and hydrochlorothiazide to the weight of inulin lauryl carbamate is 1:(0.5-2), and the weight ratio of irbesartan to hydrochlorothiazide is 12:1. The tablet has the advantages of high dissolution rate and high uniformity. The preparation method of the tablet can be used for solving the problems of electrostatic adsorption, agglomeration, poor mobility and sticking of irbesartan and hydrochlorothiazide.

Description

technical field [0001] The invention relates to a tablet and a preparation method thereof, in particular to an irbesartan hydrochlorothiazide tablet and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Essential hypertension is one of the common clinical cardiovascular diseases, with a high incidence rate and low treatment and control rates. Elevated blood pressure is an independent risk factor for stroke and coronary heart disease, and increases the risk of heart failure and cerebrovascular disease. Long-term elevated blood pressure can lead to left ventricular hypertrophy, aggravating myocardial ischemia, resulting in myocardial sclerosis, arrhythmia, heart failure and sudden death. According to research reports, nearly 70% of hypertensive patients need to use two or more drugs in combination to achieve target blood pressure. The guidelines for the prevention and treatment of hypertension in Chin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/549A61K47/36A61K9/20A61P9/12A61K31/4184
Inventor 王巍巍郭凤杨亚青王国振
Owner HEBEI LONGHAI PHARMA
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