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The application of the extract of C. chinensis in the preparation of hypoglycemic drugs

The invention relates to an extract and a technology for rushing Huangcao, which are applied to the application of the cayenne grass extract in the preparation of hypoglycemic drugs, and the application field of traditional Chinese medicine extracts, which achieves the advantages of exact curative effect, simple preparation method and obvious hypoglycemic activity. Effect

Inactive Publication Date: 2019-06-04
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported in the literature that C. chinensis has the pharmacological activity of preventing and treating hepatitis and protecting the liver, but so far there has been no report on the treatment of hyperglycemia with C. chinensis extract.

Method used

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  • The application of the extract of C. chinensis in the preparation of hypoglycemic drugs
  • The application of the extract of C. chinensis in the preparation of hypoglycemic drugs
  • The application of the extract of C. chinensis in the preparation of hypoglycemic drugs

Examples

Experimental program
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Effect test

Embodiment 1

[0029] The preparation of embodiment 1 chasing yellow grass extract

[0030] After crushing 5kg of the whole grass of C. chinensis (commercially available), soak it in 50L of 80% ethanol overnight, heat extract with 80% ethanol (80°C) for 3 times, each time 50L, each extraction time is 1 hour, combine After 3 extractions, the extract was concentrated to dryness at 50-60°C under reduced pressure, and then dried at 50-60°C to constant weight (564g). The yield was 11.3% based on crude drug amount. The prepared C. chinensis extract was subjected to HPLC (high performance liquid phase) detection according to Example 4.

Embodiment 2

[0031] The preparation of embodiment 2 chasing yellow grass extract

[0032] After crushing 5kg of the whole grass of C. chinensis (commercially available), soak it in 50L of 50% ethanol overnight, heat extract with 50% ethanol (80°C) for 3 times, each time 50L, each extraction time is 1 hour, combine After 3 extractions, the extract was concentrated to dryness at 50-60°C under reduced pressure, and then dried at 50-60°C to a constant weight (541g). The yield was 10.8% based on the crude drug amount. The prepared C. chinensis extract was subjected to HPLC (high performance liquid phase) detection according to Example 4.

Embodiment 3

[0033] The preparation of embodiment 3 chasing yellow grass extract

[0034] After crushing 5kg of the whole grass of C. chinensis (commercially available), soak it in 50L of 20% ethanol overnight, heat extract with 20% ethanol (80°C) for 3 times, each time 50L, each extraction time is 1 hour, combine After 3 extractions, the extract was concentrated to dryness at 50-60°C under reduced pressure, and then dried at 50-60°C to constant weight (516g). The yield was 10.3% based on crude drug amount. The prepared C. chinensis extract was subjected to HPLC (high performance liquid phase) detection according to Example 4.

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Abstract

The invention discloses an application of penthorum Chinese pursh extract in the preparation of hypoglycemic drugs. The penthorum Chinese pursh extract is subjected to the following experiments: (1) in-vitro alpha-amylase activity inhibition experiments, wherein the experiment results show that the penthorum Chinese pursh extract has a prominent inhibiting effect on alpha-amylase; (2) experiment of penthorum Chinese pursh extract's effect on mouse starch tolerance, wherein the experiment results show that the penthorum Chinese pursh extract can prominently reduce the blood sugar concentration after the mice eat the starch; (3) acute toxicity experiment of penthorum Chinese pursh extract on mice through intragastric administration, wherein the experiment results show that the penthorum Chinese pursh extract has no prominent side or toxic effect on mice when reducing the blood sugar level. So the invention provides a novel way for preventing and treating diabetes in clinic. The penthorum Chinese pursh extract has a simple preparation method and a great application value in clinic.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract, in particular to the application of the traditional Chinese medicine extract, and in particular to the application of the extract of C. chinensis in the preparation of hypoglycemic drugs. Background technique [0002] Due to many factors such as the improvement of living standards, changes in dietary structure, increasingly tense pace of life, and a less active and more sedentary lifestyle, the incidence of diabetes worldwide is increasing rapidly. Diabetes has become the third serious threat after tumors and cardiovascular diseases. Chronic diseases of human health. When diabetic patients fail to achieve the goal of blood sugar control after diet and exercise treatment, drug therapy is required. For this reason, the research and development of effective hypoglycemic drugs have extremely important significance. At present, the drugs used for hypoglycemia mainly include oral hypoglycemic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P3/10
Inventor 孙连娜黄豆豆李君丽孙蕾黄光辉陈万生
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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