Test strip card based on quantum dot labeling

A technology of quantum dots and test strip cards is applied in the field of test strips and cards marked by quantum dots, which can solve the problems of low detection efficiency, low sensitivity, difficult sample quantification, etc., and achieve the effect of less sample consumption and short time.

Inactive Publication Date: 2014-03-26
CHENGDU LINGYU BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages are: (1) It can only detect samples qualitatively, but it is difficult to achieve quantitative samples
(2) It is difficult to detect multiple components of the sample at the same time, and the detection efficiency is low
(3) For some samples with extremely low antigen or antibody content, the color of colloidal gold is very light, it is difficult to judge the result with the naked eye, and the detection sensitivity is low
Although the patent can realize simultaneous detection of multiple components, what is claimed is a method, and no claim is made for the rapid immunochromatographic test strip product based on quantum dot labeling
Moreover, this method has deficiencies: (1) To achieve multi-component detection of samples, multiple corresponding detection lines need to be set on the analysis membrane at the same time, that is, each detection line is only used to detect one indicator in the sample, and the detection efficiency is low
(2) Use ultraviolet light to irradiate the test strip to observe the presence or strength of the fluorescent line to judge whether the sample contains the target object. In a real sense, this is still a qualitative detection, or at most it can only achieve certain The determination of the lowest detectable limit of the detected substance cannot fundamentally realize the accurate concentration detection of any component in the sample, and the sensitivity is still low
Storage media recently developed in the information field, such as RFID tags (also known as radio frequency identification tags), IC chips, magnetic codes, bar codes, etc., are used for information access and identification and are now widely used in computers, communications, electronics, commerce, and transportation Control management and other fields, especially RFID tags, small in size, large in storage information capacity, identification without manual intervention, is an ideal means of information access identification, but few people use it for biomedical testing at present

Method used

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  • Test strip card based on quantum dot labeling
  • Test strip card based on quantum dot labeling
  • Test strip card based on quantum dot labeling

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Experimental program
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Embodiment 1

[0035] Figure 1-4 The first embodiment is described. The first embodiment is one of the preferred solutions of the quantum dot marking test strip card of the present invention.

[0036] Figure 1-4 In the preferred embodiment, the quantum dot marking test strip card includes a cartridge 3 and a quantum dot marking test strip 2. The quantum dot marking test strip 2 includes a sample pad 4, a marking pad 5, an analysis film 7, and a water absorbing pad 8 which are sequentially lapped and fixed on the bottom lining 1. The analysis membrane 7 has a detection zone 6. The upper surface of the cartridge 3 has a sample hole 9 at a position corresponding to the test strip sample pad 4, and the upper surface of the cartridge 3 has a detection window 10 at a position corresponding to the test strip analysis film 7. A storage medium 11 is installed on the cartridge 3.

[0037] The marking pad 5 of the quantum dot labeling test strip 2 is coated with a certain target object marked by a sing...

Embodiment 2

[0045] Figure 5-8 The second embodiment is described. The second embodiment is another preferred solution of the quantum dot marking test strip card of the present invention.

[0046] Figure 5-8 In the preferred embodiment, the quantum dot marking test strip card includes a cartridge 3 and a quantum dot marking test strip 2. The quantum dot marking test strip 2 includes a sample pad 4, a marking pad 5, an analysis film 7, a water absorption pad 8, and a test strip reaction end point indicator 12 that are sequentially overlapped and fixed on the bottom lining 1. The analysis membrane 7 has a detection zone 6. The upper surface of the cartridge 3 has a sample hole 9 at a position corresponding to the sample pad 4 of the test strip, and the upper surface of the cartridge 3 has a detection window 10 at a position corresponding to the analysis film 7 of the test strip. The upper box surface of 3 has an observation window 13 at the position corresponding to the indication label 1...

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Abstract

The invention relates to the field of in-vitro diagnosis, particularly a test strip card based on quantum dot labeling. The test strip card comprises a card box (3) and a quantum dot labeling test strip (2) in the card box (3), wherein the card box is provided with a storage medium (11) in which a sample tested object standard curve and other detection information are stored. When detecting a sample, an instrument with a signal detection function acquires characteristic signals of a detection belt (6) of the test strip (2) and calculates to obtain single component concentration or multiple component concentrations in the sample in combination with the tested object standard curve or coefficient parameters simultaneously read from the storage medium (11) by the instrument. The test strip card for detecting samples is simple and quick, and has the characteristics of high sensitivity, objective result, high use flexibility and the like.

Description

technical field [0001] The invention belongs to the field of in vitro diagnosis, and specifically relates to a quantum dot marker which has detection information such as a standard curve or coefficient parameters of the tested object, and can quickly quantify the concentration of a single component or multiple components of a sample in combination with an instrument with a signal detection function. test strip card. Background technique [0002] Colloidal gold immunochromatography (Gold-Immunochromatography Assay, GICA) has been widely used in various aspects of immunoassays. It uses a microporous membrane as a carrier, and uses the capillary action of the microporous membrane to make it drop on one end of the membrane strip. The liquid sample slowly seeps to the other end of the microporous membrane. If there are specific antigens or antibodies in the liquid, they can be combined with immunogold and then combined with the corresponding antibody or antigen coated on the micr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/558
CPCG01N33/558G01N33/588G01N2800/00G01N33/58G01N33/54388
Inventor 马义才顾敏马灵
Owner CHENGDU LINGYU BIOTECH
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