Novel magnetic resonance contrast medium having electrochemical sensing function and preparation method thereof

A magnetic resonance contrast agent, electrochemistry technology, applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agent, material electrochemical variables, etc., can solve the problems of wide particle size distribution, poor electrical conductivity and thermal stability, poor crystallinity and so on , to achieve the effect of high sensitivity, high stability and excellent performance

Active Publication Date: 2014-04-23
WENZHOU MEDICAL UNIV
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Problems solved by technology

Its products often have disadvantages such as easy agglomeration, poor crystallinity,

Method used

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  • Novel magnetic resonance contrast medium having electrochemical sensing function and preparation method thereof
  • Novel magnetic resonance contrast medium having electrochemical sensing function and preparation method thereof
  • Novel magnetic resonance contrast medium having electrochemical sensing function and preparation method thereof

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Embodiment Construction

[0022] Add graphite powder and chitosan solids with a weight ratio of 1:30 into the ball mill tank, and ball mill for 10-12 hours at a ball milling speed of 500 rpm to obtain a functionalized graphene material, and then the obtained functionalized graphene material The graphene material is added to the PLASMA (plasma) instrument, and then pure acetic acid vapor enters the instrument at high temperature, and the acetic acid vapor is cracked under the action of electricity to hit the carboxyl group in the acetic acid on the graphene material. Carboxylation modification.

[0023] We found through experiments that the weight ratio of graphite powder and chitosan solid is between 1:20-1:40, and the product performance is not much different.

[0024] 10 mg of the functionalized graphene material after carboxylation modification is ultrasonically dispersed into 20 ml of water, and then magnetic nanoparticles containing ferrous ions and ferric ions are added in the water, and the ...

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Abstract

The invention relates to a novel magnetic resonance contrast medium having an electrochemical sensing function and a preparation method thereof. The preparation method provided by the invention realizes full integration of a normal temperature solid phase ball-milling method, a plasma technology and a coprecipitation method. The method comprises the steps of firstly, preparing nitrogen edge functionalized graphene having electrochemical activity at a certain ball-milling speed at normal temperature and under normal pressure without addition of any reagent; secondly, implementing carboxylation modification on the functionalized graphene material through the plasma technology; finally, modifying a magnetic nano material on the carboxyl functionalized graphene through the coprecipitation method. Analysis through a transmission electron microscope and an atomic force microscope discovers that the functionalized graphene material is of a lamellar structure which is about 1nm thick, and deposited magnetic nano particles uniformly cover the graphene sheet by particle size about 15nm. The novel magnetic resonance contrast medium having the electrochemical sensing function is prepared by modifying glucose oxidase on the composite nano material through an amidation method and spinning on an ITO (indium tin oxide) glass electrode.

Description

technical field [0001] The invention belongs to the field of research and development of new contrast agents, and in particular relates to a novel magnetic resonance contrast agent with electrochemical sensing function and a preparation method thereof. Background technique [0002] Magnetic nanoparticle-modified nitrogen edge-functionalized graphene is a new type of graphene composite material, which has good electrochemical catalytic performance and magnetic properties, so it is expected to become a new magnetic resonance imaging contrast agent with sensing function. Magnetic / graphene composite nanomaterials have been widely used in many fields due to their simple preparation method and low cost, such as magnetic resonance imaging, electromagnetic shielding interference, supercapacitors, biosensors, etc. [0003] At present, the preparation methods of magnetic / graphene composite nanomaterials mainly include coprecipitation method, in situ synthesis method and self-assembly ...

Claims

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Application Information

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IPC IPC(8): A61K49/06G01N27/26
Inventor 张文晶李晓健刘勇戴黎明
Owner WENZHOU MEDICAL UNIV
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