Method for preparing technetium (99mTc) methylene diphosphonate injection medicament with long effective period
A technology of methylene diphosphonate and stannous methylene diphosphate is applied in the field of preparation of technetium [99mTc] methylene diphosphonate injection with long validity period, and can solve problems such as waste and achieve Easy to transport, good imaging effect, stable quality effect
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[0022] A kind of technetium [ 99m Tc] the method for methylene bisphosphonate injection drug, in the preparation technetium [ 99m After Tc] methylene bisphosphonate injection, technetium [ 99m Add vitamin C injection to Tc] methylene bisphosphonate injection. The method specifically includes the following steps:
[0023] (1) Dilute vitamin C injection to 0.005g / L-0.05g / L;
[0024] (2) extract high technetium [ 99m Sodium Tc] acid injection, the activity is 10 ~ 200mCi, and diluted to 4ml;
[0025] (3) Take out the freeze-dried product of 5 mg / bottle of stannous methylene diphosphate for injection from the refrigerator and place it at room temperature;
[0026] (4) high technetium [ 99m Sodium Tc] acid injection is injected into stannous methylene diphosphate freeze-dried product at one time, shakes, fully dissolves, and stands still for 5 minutes to obtain technetium[ 99m Tc] methylene bisphosphonate injection;
[0027] (5) Extract 0.1ml of the diluted vitamin C inject...
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