Method for measuring tween-80 content in compound musk injection by using near-infrared spectrum

A technology of near-infrared spectroscopy and near-infrared spectrometer, which is applied in the field of quality inspection of liquid preparations of traditional Chinese medicine

Active Publication Date: 2014-04-30
GUANGZHOU ZHONGDA NANSHA TECH INNOVATION IND PARK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The object of the present invention is to overcome the deficiencies and shortcomings of the prior art, and provide a method for measuring Tween-80 content in compound musk inj

Method used

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  • Method for measuring tween-80 content in compound musk injection by using near-infrared spectrum
  • Method for measuring tween-80 content in compound musk injection by using near-infrared spectrum
  • Method for measuring tween-80 content in compound musk injection by using near-infrared spectrum

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] (1) Collection of calibration sets and determination of their spectra

[0043] Select Tween-80 standard products from Nanjing Well Chemical Co., Ltd. (batch numbers are 20101101, 20101110, 20110114, 20120201) to establish a calibration set;

[0044] Weigh the Tween-80 standard product, and use the specific gravity method to prepare a total of 130 samples of Tween-80 standard solution with a uniform distribution of concentration gradient from 0.1 to 5% (g / g) (0.05% as an interval concentration), mix well, spare;

[0045] Use the near-infrared spectrometer to collect the original spectral data of the calibration set: at room temperature (15-30°C), take 1mL solution for each sample in the calibration set, and use the Bruker spectrometer Tensor37 (Germany Bruker Spectroscopy Instrument Co., Ltd., Germany, light source: tungsten halogen lamp, Detector: InGaAs detector) for data collection to obtain the original near-infrared spectrum data of the Tween-80 standard solution; ...

Embodiment 2

[0068] (1) Collection of calibration sets and determination of their spectra

[0069] Select Tween-80 standard products from Nanjing Well Chemical Co., Ltd. (batch numbers are 20101101, 20101110, 20110114, 20120201) to establish a calibration set;

[0070] Weigh the Tween-80 standard product, and use the specific gravity method to prepare a total of 130 samples of Tween-80 standard solution with a uniform distribution of concentration gradient from 0.1 to 5% (g / g) (0.05% as an interval concentration), mix well, spare;

[0071] Use the near-infrared spectrometer to collect the original spectral data of the calibration set: at room temperature (15-30°C), take 1mL solution for each sample in the calibration set, and use the Bruker spectrometer Tensor37 (Germany Bruker Spectroscopy Instrument Co., Ltd., Germany, light source: tungsten halogen lamp, Detector: InGaAs detector) for data collection to obtain the original near-infrared spectrum data of the Tween-80 standard solution; ...

Embodiment 3

[0085] (1) Collection of calibration sets and determination of their spectra

[0086] Select Tween-80 standard products from Nanjing Well Chemical Co., Ltd. (batch numbers are 20101101, 20101110, 20110114, 20120201) to establish a calibration set;

[0087] Weigh the Tween-80 standard product, and use the specific gravity method to prepare a total of 130 samples of Tween-80 standard solution with a uniform distribution of concentration gradient from 0.1 to 5% (g / g) (0.05% as an interval concentration), mix well, spare;

[0088] Use the near-infrared spectrometer to collect the original spectral data of the calibration set: at room temperature (15-30°C), take 1mL solution for each sample in the calibration set, and use the Bruker spectrometer Tensor37 (Germany Bruker Spectroscopy Instrument Co., Ltd., Germany, light source: tungsten halogen lamp, Detector: InGaAs detector) for data collection to obtain the original near-infrared spectrum data of the Tween-80 standard solution; ...

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Abstract

The invention belongs to the technical field of quality detection of traditional Chinese medicine liquid preparations and particularly relates to a method for measuring tween-80 content in a compound musk injection by using a near-infrared spectrum. The method comprises the following steps of (1) collecting a calibration set and measuring the spectrum; (2) establishing and inspecting a calibration model; (3) forecasting the calibration model; and (4) measuring an unknown compound musk injection sample. The method provided by the invention has the advantages that input, calculation and output of spectrum data are realized by a computer and support software, the whole process time is short, rapid and exact, the method is used for rapid inspection in a laboratory, on-line production detection, the production efficiency is improved, manpower and material resources are greatly saved, big innovation is created fro the increase of the quality standard and rapid detection of the compound musk injection, and economical and social benefits are great.

Description

technical field [0001] The invention belongs to the technical field of quality detection of liquid preparations of traditional Chinese medicines, in particular to a method for determining the content of Tween-80 in compound musk injection by near-infrared spectroscopy. Background technique [0002] According to the definition of "Chinese Pharmacopoeia" (2010 edition), traditional Chinese medicine injection is "refers to the extract and purification of medicinal materials for injecting into the body, emulsion, powder or concentrated solution prepared before use. Bacterial preparations." The compound musk injection is mainly composed of artificial musk, turmeric, patchouli, calamus, borneol, menthol and other medicinal materials through modern production technology, and added polysorbate-80 (Tween-80) Prepared. The compound musk injection has greatly improved the effective supply and bioavailability of traditional Chinese medicine to the human body through vascular administra...

Claims

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Application Information

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IPC IPC(8): G01N21/3577G01N21/359
Inventor 肖雪张湘东付婵马晋芳史庆龙
Owner GUANGZHOU ZHONGDA NANSHA TECH INNOVATION IND PARK
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