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Children's oral nucleoside antiviral pharmaceutical gel unit based on improved gel matrix and preparation method thereof

A technology of gel matrix and antiviral drugs, which is applied in the direction of antiviral agents, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve the problem that can only be applied locally to the skin and body cavities such as the nasal cavity and vagina. And the rectum, inaccurate dosage, difficult to use on time and other problems, to achieve the effect of reducing the fear of taking medicine, good curative effect, and good taste

Active Publication Date: 2016-11-30
黑龙江童医生儿童生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The technical shortcomings of nucleoside antiviral drugs in different dosage forms include: for injections, children have a sense of fear, and it is difficult to consciously cooperate with doctors and parents to use them on time; for capsules, when children use less than one capsule, they often take capsules The method of pouring out the medicine in the medicine and taking it with water; for the bottled oral liquid or syrup, there is the disadvantage of repeated pollution for two or more times; To be precise, some coated tablets, sustained-release tablets, and dispersible tablets lose their specific functions such as protection, taste masking, controlled release, and isolation after being artificially divided; as for gels, they can only be used locally on the skin and body cavities Such as the nasal cavity, vagina and rectum, such as penciclovir gel (1%) and acyclovir gel (10g: 0.1g) that have been marketed, and there is no report of oral nucleoside antiviral gel

Method used

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  • Children's oral nucleoside antiviral pharmaceutical gel unit based on improved gel matrix and preparation method thereof
  • Children's oral nucleoside antiviral pharmaceutical gel unit based on improved gel matrix and preparation method thereof
  • Children's oral nucleoside antiviral pharmaceutical gel unit based on improved gel matrix and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1 Ribavirin gel (QQ glycoform)

[0046]

[0047]

[0048] Preparation method: Weigh the pectin, add deionized water, stir under boiling to fully dissolve the pectin into the pectin solution, add sucrose while it is hot to completely dissolve, cool to 60°C, then add ribavirin and other auxiliary materials, Stir well, add water to 1000ml and fill the mold immediately.

[0049] The moisture permeability rate of the airtight package of the present embodiment QQ sugar is less than 200g / (m 2 24h), the air permeability is less than 40000cm 3 / (m 2 24h), the material is high-density polyethylene (HDPE).

Embodiment 2

[0050] Embodiment 2 famciclovir gel (jelly type)

[0051]

[0052]Preparation method: Take agar, calcium chloride, add appropriate amount of deionized water, boil and stir to fully swell into a colloidal solution, and add sucrose while hot to dissolve it. Cool to 60°C. Famciclovir and other ingredients are completely dissolved by adding an appropriate amount of deionized water. Mix the two solutions and stir evenly. Add water to 1000ml and immediately fill the jelly.

[0053] The moisture permeability of the airtight package of the jelly of this embodiment is less than 200g / (m 2 24h), the air permeability is less than 40000cm 3 / (m 2 24h), the material is low-density polyethylene (LDPE).

Embodiment 3

[0054] Embodiment 3 Valacyclovir hydrochloride gel (sucking type)

[0055]

[0056] Preparation method: Take carrageenan, konjac gum, and calcium chloride, add deionized water, boil and stir to fully swell into a colloidal solution, and cool to 60°C. Add other components such as valacyclovir hydrochloride to completely dissolve in deionized water, mix the two solutions, stir evenly, and fill immediately.

[0057] The moisture permeability rate of the airtight package of fruit smoothies in this embodiment is less than 200g / (m 2 24h), the air permeability is less than 40000cm 3 / (m 2 24h), the material is polypropylene (PP).

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Abstract

The invention relates to a child-type oral nucleoside antiviral pharmaceutical gel unit based on an improved gel matrix, the gel unit comprising a gel carrying nucleoside antiviral drugs, and a hermetic package for holding the gel , the gel uses an improved gel matrix, the weight ratio of the nucleoside antiviral drug to the improved gel matrix is ​​1-150:2-62, and the improved gel matrix includes 2-60 weight A water-soluble gel base of 0.5-2 parts by weight and a modifier of 0.5-2 parts by weight. The beneficial effect of the present invention is that it provides a child-type antiviral gel unit based on the improved gel matrix, which adopts a number of innovations including a unique ratio of water-soluble gel matrix and modifier, and can be used in general Different gel forms such as QQ candies, jellies, smoothies or xerogels.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a child-type oral nucleoside antiviral pharmaceutical gel unit based on an improved gel matrix and a preparation method thereof. Background technique [0002] The technical shortcomings of nucleoside antiviral drugs in different dosage forms include: for injections, children have a sense of fear, and it is difficult to consciously cooperate with doctors and parents to use them on time; for capsules, when children use less than one capsule, they often take capsules The method of pouring out the medicine in the medicine and taking it with water; for the bottled oral liquid or syrup, there is the disadvantage of repeated pollution for two or more times; To be precise, some coated tablets, sustained-release tablets, and dispersible tablets lose their specific functions such as protection, taste masking, controlled release, and isolation after being artificially divided; as ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K45/00A61K31/52A61K31/522A61K31/7056A61P31/12A61P31/22A61K47/36A61K47/42A61K47/32
Inventor 姜波刘晓磊王娜闫婉露
Owner 黑龙江童医生儿童生物制药有限公司
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