A kind of intermediate for preparing lubiprostone, its preparation method and the method for preparing lubiprostone by it

A technology for lubiprostone and compound, which is applied in the field of preparing lubiprostone, can solve problems such as complicated synthesis process operation, and achieves the effects of safe operation, high synthesis efficiency, significant social and economic benefits
CN103787942BActive Publication Date: 2017-02-15连云港恒运药业有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
连云港恒运药业有限公司
Publication Date
2017-02-15

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Abstract

The invention relates to an intermediate for preparing lubiprostone, a preparation method of the intermediate and a method for preparing the lubiprostone through the intermediate, in particular to a compound as shown in a formula V for preparing the lubiprostone (as shown in a formula I), a preparation method of the compound and a method for preparing the lubiprostone through the compound. The method comprises the following steps: performing reduction treatment on the compound as shown in the formula V, performing selective deprotection and hydroxyl oxidation to obtain a compound as shown in a formula II, and performing hydroxyl deprotection on the compound as shown in the formula II to prepare the lubiprostone as shown in the formula I. The method is easy and convenient to operate, high in synthetic yield and suitable for large-scale production.
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Description

technical field

[0001] The invention relates to an intermediate for preparing lubiprostone, a preparation method thereof and a method for preparing lubiprostone through the intermediate. Background technique

[0002] Irritable bowel syndrome (IBS) is a gastrointestinal functional disease caused by the interaction of digestive tract, mental state and intestinal lumen factors. According to its main symptoms, it can be divided into three types: diarrhea type, constipation type, and alternating type (that is, diarrhea and constipation appear alternately). The prevalence rate of the disease in my country's cities is about 10.5%. Although IBS is not life-threatening, it seriously affects the daily life and work of patients due to long-term recurrent attacks.

[0003] Irritable bowel syndrome with constipation (IBS-C), characterized by infrequent bowel movements and discomfort with bowel movements, is estimated to affect 4-5 million patients in the United States (approximately 2% ...

Claims

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