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Biodegradable macromolecular material for preventing postoperative adhesion and preparation method thereof

A polymer material and biological technology, which is applied in the field of biodegradable polymer materials for preventing postoperative adhesion and its preparation, can solve the problems of complicated operation steps and long preparation period, and achieves simple operation steps, good physical and chemical properties, and improved performance. The effect of efficiency

Active Publication Date: 2014-05-21
BEIJING DATSING BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The organic solvent introduced by this technology needs to be thoroughly cleaned to ensure the biological safety of the product. In addition, the process includes more complicated operation steps and a longer preparation cycle

Method used

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  • Biodegradable macromolecular material for preventing postoperative adhesion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Biodegradable polymer material for preventing postoperative adhesions and its preparation

[0028] Include the following steps:

[0029] (1) Sodium hyaluronate with a molecular weight of 1 million Daltons was dissolved in purified water to prepare a solution with a concentration of 0.6%. Stir to fully dissolve the sodium hyaluronate.

[0030] (2) Add water-soluble carbodiimide (EDC) to the sodium hyaluronate solution, so that the molar ratio of EDC to sodium hyaluronate is 1:5, mix well, and let stand at room temperature for 12 hours.

[0031] (3) Use dialysis paper to dialyze the mixed solution, and replace the purified water for dialysis regularly.

[0032] (4) Prepare the water-soluble chitosan into a solution with a concentration of 0.2%, and use a stirrer to fully mix it with the washed self-crosslinked sodium hyaluronate solution.

[0033] (5) Pour the mixed solution into a mould, freeze sufficiently and then dry it with a freeze dryer to obtain a spo...

Embodiment 2

[0034] Example 2 Biodegradable polymer material for preventing postoperative adhesions and its preparation

[0035] (1) Sodium hyaluronate with a molecular weight of 1 million Daltons was dissolved in purified water to prepare a solution with a concentration of 1%. Stir to fully dissolve the sodium hyaluronate.

[0036] (2) Slowly add water-soluble carbodiimide (EDC) dropwise to the sodium hyaluronate solution, so that the molar ratio of EDC to sodium hyaluronate is 1:8, stir well, and let stand at room temperature for 12 hours.

[0037] (3) Dialyze the mixed solution with dialysis paper, and replace the purified water for dialysis every 1 hour. Cumulatively wash 12 times.

[0038] (4) Prepare the water-soluble chitosan into a solution with a concentration of 0.2%, and use a stirrer to fully mix it with the washed self-crosslinked sodium hyaluronate solution.

[0039](5) Pour the mixed solution into a mold, and vacuum-dry it at 40° C. for 24 hours to obtain a transparent fi...

Embodiment 3

[0040] Example 3 Biodegradable polymer material for preventing postoperative adhesions and its preparation

[0041] (1) Sodium hyaluronate with a molecular weight of 1.5 million Daltons was dissolved in purified water to prepare a solution with a concentration of 0.8%. Stir to fully dissolve the sodium hyaluronate.

[0042] (2) Slowly add 2-chloro-1-methylpyridinium iodide (CMPI) dropwise into the sodium hyaluronate solution, so that the molar ratio of CMPI to sodium hyaluronate is 1:4, and after fully stirring and mixing, Stand at room temperature for 12h.

[0043] (3) Dialyze the mixed solution with dialysis paper, and replace the purified water for dialysis every 1 hour. After accumulatively washing 4 times, the purified water was replaced every 2 hours. After washing 2 times, the cross-linked sodium hyaluronate solution was kept in purified water for dialysis for 8 hours.

[0044] (4) Prepare the water-soluble chitosan into a solution with a concentration of 0.4%, and u...

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Abstract

The invention provides a biodegradable macromolecular material for preventing postoperative adhesion. A method for preparing the biodegradable macromolecular material comprises the steps of adding a cross-linker into a 0.5-2.5% sodium hyaluronate solution, carrying out cross-linking reaction at the temperature of 0-80 DEG C, dialyzing a mixed solution in water after the reaction is ended, uniformly mixing the dialyzed solution and 0.2-2.5% water-soluble chitosan, and then, drying, thereby obtaining the biodegradable macromolecular material. The degradable biological material prepared by the method has good physical and chemical properties and biocompatibility, and can be used for effectively preventing the occurrence of postoperative adhesion.

Description

technical field [0001] The invention relates to the field of polymer materials, in particular to a biodegradable polymer material for preventing postoperative adhesions and a preparation method thereof. Background technique [0002] Adhesions are a common problem after surgery, especially abdominal surgery. Postoperative adhesions can lead to serious complications such as in abdominal surgery where adhesions can lead to conditions such as intestinal obstruction, infertility and chronic pelvic pain. At present, commonly used anti-adhesion materials include polylactic acid, sodium hyaluronate, chitosan, chitosan, collagen, etc. Among them, sodium hyaluronate has been proven to reduce the occurrence of adhesions after abdominal surgery, so it is an ideal material for preventing postoperative adhesions. [0003] Hyaluronic acid is a heteropolysaccharide composed of alternating residues of D-glucuronic acid and N-acetyl-D-glucosamine. Under normal physiological conditions in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04C08J3/24C08L5/08
Inventor 翟晖袁源李次会李湘杰殷瑞贤
Owner BEIJING DATSING BIO TECH
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