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Ganoderma sinense polysaccharide oral liquid composition and preparation method thereof

A liquid composition and oral liquid technology, applied in the field of medicine, can solve the problems of large drug dispersion, easy mildew and instability of aqueous liquid preparations, and achieve low cost, prevention and treatment of leukocytes and thrombocytopenia, and stability. Good results

Active Publication Date: 2014-05-28
江西泽众制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, due to the high degree of dispersion of the drug in the liquid preparation and the large phase interface and interfacial energy, there is a certain degree of instability, and the aqueous liquid preparation is prone to mildew

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preparation of Zizhi polysaccharide powder:

[0027] Wash the Zizhi fruiting body and / or mycelium, drain, add water and decoct twice, decoct for 2 hours for the first time, filter the medicinal liquid with a 100-mesh filter cloth, add 5 times the amount of water to the dregs for the second The second decoction for 2 hours, the medicinal liquid was filtered with a 100-mesh filter cloth, the medicinal liquid obtained by the second decoction was combined, and concentrated under reduced pressure to a clear paste with a relative density of 1.15 (heat measurement at 50°C), and stirred into the clear paste to add 95% Ethanol until the alcohol content reaches 62%, let it stand for 24 hours, take the supernatant to recover the ethanol until there is no alcohol smell, and the precipitate after recovering the ethanol is vacuum-dried at 60°C, and the moisture content of the dry extract is controlled within 3%. Put the paste into a high-efficiency pulverizer and pulverize it into fi...

Embodiment 2

[0029] prescription:

[0030] .

[0031] Preparation:

[0032] Add propylene glycol and polyethylene glycol to 1 / 3 purified water, stir evenly, then add Zizhi polysaccharide powder, stir until completely dissolved at 35°C; add carboxymethylcellulose sodium, aspartame and sodium chloride to the solution, Mix well, cool to room temperature, and set aside; add ethylparaben and propylparaben, mix well, add purified water to 1000ml, fill, and sterilize at 115°C for 15 minutes to obtain.

Embodiment 3

[0034] prescription:

[0035] .

[0036] Preparation:

[0037] Add ethanol to 1 / 3 purified water, stir evenly, then add Zizhi polysaccharide powder, and stir until completely dissolved at 40°C; add polyvinylpyrrolidone and aspartame to the solution, mix well, cool to room temperature, and set aside; take white sugar, Mix with water, heat to dissolve, mix with the above solution evenly, add potassium benzoate, stir evenly, fill, and sterilize at 115°C for 15 minutes to obtain the product.

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PUM

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Abstract

The invention discloses a ganoderma sinense polysaccharide oral liquid composition and a preparation method thereof. The ganoderma sinense polysaccharide oral liquid composition comprises the following components in parts by weight; 5 to 12 parts of ganoderma sinense polysaccharide, 0.5 to 3.5 parts of a solubilizer, 0.3 to 2.0 parts of a suspending agent, 1.0 to 3.0 parts of a flavoring agent, and 0.1 to 0.5 part of a preservative. The oral liquid composition provided by the invention has the advantages of high stability and excellent mouthfeel, and can effectively prevent and treat leukopenia and thrombocytopenia after being taken.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an oral liquid composition of Zizhi polysaccharide and a preparation method thereof. Background technique [0002] Zizhi (parts by weight anoderma Sinense zhao Xu et zhan) belongs to Ganodermaceae, including fruiting body and mycelium. Zizhi polysaccharide is the total polysaccharide extracted from the culture of Zizhi, which has the functions of nourishing and strengthening, nourishing the heart and calming the nerves. Zizhi Polysaccharide Tablets is a non-toxic and side-effect medicine provided by the applicant in 1978 for the treatment of neurasthenia, leukopenia and thrombocytopenia, ionizing radiation and occupational hematopoietic injury, and leukopenia in tumor patients after radiotherapy and chemotherapy. Effective drug, the first new drug developed in the country, obtained production approval in 1985. At present, Zizhi polysaccharide tablets are recorded in the eleventh volume ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/715A61P7/00A61P7/04
Inventor 于新江
Owner 江西泽众制药股份有限公司
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