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Gel of complexone metal complex as well as preparation method and use thereof

A technology of aminocarboxyl complexing agent and metal complex, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, drug combinations, etc., and can solve the problems that cannot be prevented with the skin

Inactive Publication Date: 2014-06-11
陈郁
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] During my research, I accidentally found that the metal complexes of ammonia carboxyl complexing agents can quickly neutralize the corrosiveness of acid and alkali dangerous chemicals. It has a rapid neutralizing and clearing effect, but it can only be used as an emergency treatment after hydrofluoric acid splashes the skin, and cannot be used for the prevention before the skin

Method used

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  • Gel of complexone metal complex as well as preparation method and use thereof
  • Gel of complexone metal complex as well as preparation method and use thereof
  • Gel of complexone metal complex as well as preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Prepare aminocarboxyl complexing agent metal complex gel according to the following proportions:

[0043] Metal complexes of EDTA aminocarboxyl complexing agent and zinc ions

Embodiment 2

[0045] Prepare aminocarboxyl complexing agent metal complex gel according to the following proportions:

[0046] Metal complexes of EDTA aminocarboxyl complexing agent and aluminum ion

Embodiment 3

[0048] Prepare aminocarboxyl complexing agent metal complex gel according to the following proportions:

[0049] Metal complexes of EDTA aminocarboxyl complexing agent and iron ions

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PUM

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Abstract

The invention discloses a gel of a metal complex of complexone for external use on skin. The gel comprises metal complex of complexone, an organic acid calcium salt, a gel substrate, and pharmaceutically acceptable auxiliary materials, wherein the weight of the metal complex of the complexone accounts for 1-50% of total weight of the gel; the weight of the organic acid calcium salt accounts for 0.1-30% of total weight of the gel; the weight of the gel substrate accounts for 0.1-40% of total weight of the gel. The gel can be used for effectively preventing poisoning of fluorine dangerous chemicals such as a hydrofluoric acid, also can be quickly applied after the hydrofluoric acid is sprayed on the skin, and has the advantages of being easy to coat, free of greasiness, free of thrill, irritability or allergic reaction on the skin and mucous membranes, good in adhesiveness and uniformity on a sensitive layer, quick to dry, easy to clean, free of pollution to clothes, and the like.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a gel of ammonia carboxyl complexing agent metal complex, which is suitable for protection and first aid of fluorine-containing dangerous chemicals such as hydrofluoric acid. Background technique [0002] Hydrofluoric acid not only has the properties of acidic substances, but also has the characteristics of high toxicity and high corrosiveness. If 1% of the body surface area is exposed to high-concentration hydrofluoric acid, if it is not disposed of in time, it can cause death. Therefore, when hydrofluoric acid is splashed to How to prevent the penetration of hydrofluoric acid and neutralize the toxicity and corrosiveness of hydrofluoric acid in time is the key to reduce or avoid damage. [0003] During my research, I accidentally found that the metal complexes of ammonia carboxyl complexing agents can quickly neutralize the corrosiveness of acid and alkali dangerous che...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K9/06A61P17/00
Inventor 陈郁
Owner 陈郁
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