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Chitosan-modified nanofiber slow-release antibacterial film and preparation method thereof

A chitosan modification and nanofiber technology, which is applied in fiber treatment, fiber chemical characteristics, rayon manufacturing, etc., can solve the problem of poor binding fastness between antibacterial agents and fibers, limiting the durability of antibacterial effects, swelling and disintegration, etc. problem, to achieve the effect of lasting effect, increasing content and increasing lipophilicity

Active Publication Date: 2020-06-12
广州大鱼创福科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, chitosan and polyethylene oxide have certain water solubility, and after forming the material, they will swell and disintegrate, which will also cause a burst release effect in the later stage of release.
In addition, the existing antibacterial fibers have limited the durability of their antibacterial effects due to the poor combination of antibacterial agents and fibers.

Method used

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  • Chitosan-modified nanofiber slow-release antibacterial film and preparation method thereof
  • Chitosan-modified nanofiber slow-release antibacterial film and preparation method thereof

Examples

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Effect test

Embodiment 1

[0026] A preparation method of chitosan modified nanofiber sustained-release antibacterial film, comprising the steps of:

[0027] 1. Add 0.7g of soybean lecithin, 0.2g of cholesterol and 0.4ml of terpinen-4-ol into 20ml of chloroform, stir well to dissolve it completely, remove the chloroform by rotary evaporation at room temperature, and then use a syringe at a rate of 5ml / min Inject it into 6 times the volume of water containing 3g / L Tween 80, then homogenize at a speed of 11000r / min, dialyze and concentrate to 1 / 6 volume with 15g / L polyvinyl alcohol 6000 solution to obtain pine oil En-4-ol liposomes;

[0028] 2. Add 1g of chitosan powder with a relative molecular weight of 30kDa and a deacetylation degree of 90%, 1.5g of benzenesulfonyl chloride, 1.5g of sodium hydroxide, 0.2g of 15-crown ether-5 and 0.15g of DMAP into 60ml of dichloromethane React at 50°C for 8 hours, then wash the reactant with a sodium hydroxide solution with a concentration of 8g / L, and collect the pr...

Embodiment 2

[0031] A preparation method of chitosan modified nanofiber sustained-release antibacterial film, comprising the steps of:

[0032] 1. Add 0.5g of soybean lecithin, 0.1g of cholesterol and 0.2ml of terpinen-4-ol into 20ml of chloroform, stir well to dissolve it completely, remove the chloroform by rotary evaporation at room temperature, and then use a syringe at a rate of 3ml / min Inject it into 5 times the volume of water containing 2g / L Tween 20, then homogenize at a speed of 10000r / min, dialyze and concentrate to 1 / 5 volume with 10g / L polyvinyl alcohol 6000 solution to obtain pine oil En-4-ol liposomes;

[0033] 2, 1g relative molecular weight is 20kDa, and deacetylation degree is 80% chitosan powder, 1g benzenesulfonyl chloride, 1g sodium hydroxide, 0.1g 15-crown ether-5 and 0.1g DMAP add 50ml dichloromethane at 40 React at ℃ for 6 hours, then wash the reactant with a sodium hydroxide solution with a concentration of 5g / L, and collect the precipitate by centrifugation;

[...

Embodiment 3

[0036] A preparation method of chitosan modified nanofiber sustained-release antibacterial film, comprising the steps of:

[0037] 1. Add 0.8g of soybean lecithin, 0.3g of cholesterol and 0.5ml of terpinen-4-ol into 20ml of chloroform, stir well to dissolve it completely, remove the chloroform by rotary evaporation at room temperature, and then use a syringe at a rate of 7ml / min. Inject it into 8 times the volume of water containing 5g / L Span 80, then homogenize at a speed of 12000r / min, dialyze and concentrate to 1 / 8 volume with 20g / L polyvinyl alcohol 6000 solution to obtain pine oil En-4-ol liposomes;

[0038] 2, 1g relative molecular weight is 50kDa, and deacetylation degree is 100% chitosan powder, 2g benzenesulfonyl chloride, 1.8g sodium hydroxide, 0.3g 18-crown ether-6 and 0.2g DMAP add 75ml dichloromethane in React at 60°C for 10 hours, then wash the reactant with a sodium hydroxide solution with a concentration of 10g / L, and collect the precipitate by centrifugation;...

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Abstract

The invention belongs to the technical field of textile material processing and discloses a chitosan-modified nanofiber slow-release antibacterial film and a preparation method thereof. The preparation method comprises the steps of preparing terpinen-4-ol liposome; adding chitosan powder, benzenesulfonyl chloride, sodium hydroxide, crown ether and DMAP to dichloromethane for reaction, washing a reactant with a sodium hydroxide solution and then collecting precipitates; and dissolving the precipitates and polyethylene oxide into a 90% acetic acid solution, fully stirring the precipitates and the polyethylene oxide, adding the terpinen-4-ol liposome and carrying out electrostatic spinning to obtain a chitosan-modified nanofiber slow-release antibacterial film. Terpinen-4-ol in the prepared chitosan-modified nanofiber slow-release antibacterial film is more lasting in release and better in antibacterial effect.

Description

technical field [0001] The invention relates to the technical field of textile material processing, in particular to a chitosan modified nanofiber slow-release antibacterial film and a preparation method thereof. Background technique [0002] Chitosan is the second most abundant polysaccharide in nature—the deacetylation product of chitin, which is insoluble in water and alkaline solution, but soluble in most dilute acids, and exists in the shells and shells of crustaceans and arthropods. In the cell walls of lower plants such as fungi and algae. Chitosan is rich in resources and has the advantages of good biocompatibility, biodegradability, adhesion, antibacterial, moisture retention, non-toxic and non-polluting properties. The chemical structure of chitosan is similar to that of cellulose. They have good adsorption and compatibility. The hydroxyl groups of chitosan and some of the amino groups form many intermolecular hydrogen bonds with the hydroxyl groups of fibers, whi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H3/005D04H3/033D01D5/00C08B37/08D01F9/00D01F1/10
CPCC08B37/003D01D5/003D01D5/0092D01F1/10D01F1/103D01F9/00D04H3/005D04H3/033
Inventor 葛彦汤佳鹏付译鋆谢雅婷陈苹谢浩月
Owner 广州大鱼创福科技有限公司
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