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Method for extracting total tannin in rhodomyrtus tomentosa rhizome by using supercritical carbon dioxide

A carbon dioxide, myrtle technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of low purity and extraction rate, complicated procedures, time-consuming, etc., and achieve strong selectivity and high efficiency. Extraction rate, the effect of improving yield

Active Publication Date: 2014-06-25
GUANGXI VETERINARY RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the extraction of myrtle tannin is mainly carried out by decoction, which is complex, labor-intensive, time-consuming, and the purity and extraction rate are not high. After the optimal combination of decoction time and extraction times, the highest extraction rate is only 11.58 mg / g

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0017] Weigh 100g of medicinal material powder, soak it with 50% (V / V) ethanol according to the ratio of material to liquid 1:1, put the soaked sample into the extraction kettle in the supercritical device, and before extraction, first Refrigerate and liquefy the carbon dioxide, set the extraction pressure to 20MPa, and the temperature to 55°C, adjust the opening of the inlet valve of the carbon dioxide into the collection kettle, control the pressure of the collection kettle at 5MPa, and control the temperature at 35°C, add 50% (V / V) Ethanol is used as the entrainer, and the entrainer is added to the extraction kettle by a high-pressure pump at a flow rate of 4g / min. After the extraction pressure and temperature reach the preset values, start timing. After 1.5 hours of extraction, stop the extraction, close the carbon dioxide cylinder, and open The manual exhaust valve is used for pressure relief, and the obtained myrtle tannin extract is collected from the outlet of the colle...

example 2

[0019] Weigh 100g of medicinal material powder, soak it with 10% (V / V) dimethylformamide solution according to the ratio of material to liquid 1:1, put the soaked sample into the extraction kettle in the supercritical device, Refrigerate and liquefy the carbon dioxide before extraction, set the extraction pressure to 25MPa and the temperature to 50°C, adjust the opening of the inlet valve of the carbon dioxide into the collection kettle, control the pressure of the collection kettle at 5MPa, and at the same time control the temperature at 35°C, add 10% ( V / V) dimethylformamide is used as entrainer, and the entrainer is added into the extraction kettle by a high-pressure pump at a flow rate of 5g / min. After the extraction pressure and temperature reach the preset value, start timing, and stop after 0.5h of extraction. For extraction, close the carbon dioxide gas cylinder, open the manual exhaust valve for pressure relief, and receive the obtained myrtle tannin extract from the o...

example 3

[0021] Weigh 100g of medicinal material powder, soak it with 10% (V / V) dimethyl sulfoxide solution according to the ratio of material to liquid 1:1, put the soaked sample into the extraction kettle in the supercritical device, Refrigerate and liquefy the carbon dioxide before extraction, set the extraction pressure to 15MPa, and the temperature to 45°C, adjust the opening of the inlet valve of the carbon dioxide into the collection kettle, control the pressure of the collection kettle at 5MPa, and control the temperature at 25°C, add 10% ( V / V) dimethyl sulfoxide is used as entrainer, and the entrainer is added into the extraction kettle by a high-pressure pump at a flow rate of 4g / min. After the extraction pressure and temperature reach the preset value, start timing, and stop after 1 hour of extraction. For extraction, close the carbon dioxide gas cylinder, open the manual exhaust valve for pressure relief, and receive the obtained myrtle tannin extract from the outlet of the...

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Abstract

The invention relates to a method for extracting total tannin in rhodomyrtus tomentosa rhizome by using a supercritical carbon dioxide technique. The method comprises the following steps: pressurizing food-grade CO2 to convert food-grade CO2 into supercutical fluid as an extraction solvent, adding an entrainer for improving the extraction efficiency, crushing the rhizome of rhodomyrtus tomentosa, soaking the crushed rhizome of rhodomyrtus tomentosa, putting the soaked rhizome of rhodomyrtus tomentosa into an extraction kettle, selecting appropriate process parameters such as temperature, pressure, time, an entrainer and concentration so as to obtain an extract, diluting the extract, then inspecting the diluted extract according to a tannin testing method issued by China Veterinary Pharmacopoeia, and calculating the tannin content of the extract. The method is simple, economical and high in operability of process procedures and can be applied to industrial production, and the obtained rhodomyrtus tomentosa tannin can be applied to Chinese medicine production.

Description

technical field [0001] The invention relates to a method for extracting total tannin from rhizomes of myrtle by using supercritical carbon dioxide, which belongs to the important technical field of traditional Chinese medicine development and is specially used for extracting tannin from myrtle. technical background [0002] Myrtle Rhodomyrtus tomentosa (Ait.) Hassk. is a Myrtle family plant, also known as hypericum peach, shanrenzi, suyuanzi, pomegranate seed, etc. It is a traditional Chinese herbal medicine commonly used by folks in southern my country. Stems, leaves, and fruits are used as medicines, with sweet, astringent, and flat flavors; they contain flavonoids, tannins, volatile oils, polysaccharides, and terpenes. Activate collaterals, remove blood stasis and stop bleeding; it is often used for acute and chronic gastroenteritis, indigestion, dysentery, etc. In addition, it also has pharmacological effects such as antioxidant, antibacterial, and antiviral. [0003] At ...

Claims

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Application Information

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IPC IPC(8): A61K36/61A61K125/00
Inventor 孟菲赵武刘伟覃振华郭善康孙建华银慧慧姜源明
Owner GUANGXI VETERINARY RES INST
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