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Method for producing and processing rabbit brain powder

A processing method and technology of rabbit brain powder, which can be used in pharmaceutical formulations, extracellular fluid diseases, unknown raw materials, etc., can solve the problems of difficult separation process, increased crushing cost, and many impurities in blood vessels and meninges.

Active Publication Date: 2014-07-09
青岛康大爱博生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the brain tissue is tightly combined with blood vessels and meninges, it is impossible to completely remove it by this method. Subsequent direct homogenization, crushing and drying will lead to increased crushing costs. Acetone forms a colloidal solution, which is difficult to separate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1 A kind of production processing method of rabbit brain powder, comprises the following steps:

[0013] 1. Soak the fresh rabbit brain in zero-degree acetone for about 10 minutes, and then use tweezers to remove the blood vessels and meninges in the rabbit brain;

[0014] 2. Put the rabbit brain from which the blood vessels and meninges have been removed into an extrusion device soaked in acetone. Control the volume of acetone to be twice the weight of the rabbit brain. meninges;

[0015] 3. Squeeze the rabbit brain into the grinder through the squeeze piston in the middle of the squeeze device, and the grinder grinds the rabbit brain for 10 minutes at a speed of 1 second / time;

[0016] 4. After grinding, start the filter screen at the bottom of the grinder to further filter out blood vessels and meningeal impurities, then add 20% acetone, shake gently for a few times and then centrifuge at 2000rpm / min for 3 minutes, remove the acetone solvent after centrif...

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Abstract

The invention relates to a method for producing and processing rabbit brain powder. The method for producing and processing rabbit brain powder includes the following steps: (1) soaking fresh rabbit brains in low-temperature acetone or physiological saline, and removing blood vessels and meninges; (2) putting the rabbit brains with blood vessels and meninges removed in an extruding device soaked in acetone, and extruding the rabbit brains from the extruding device into a grinding machine; (3) grinding the rabbit brains by using the grinding machine in a slow grinding manner; (4) after the grinding operation, starting a filter screen at the bottom of the grinding machine to further filter out the blood vessels and meninge impurities, adding the acetone, slightly shaking for multiple times, centrifuging, then removing the acetone solvent; drying, packaging and storing at 4 DEG C. The method for producing and processing rabbit brain powder provided by the invention is used for further removing more than 70% of the residual blood vessels and meninge impurities by extruding and filtering; 20% of acetone is added before the grinding type crushing and centrifuging steps, so as to reduce the colloid state of the solution, thereby reducing the difficulty of subsequent centrifuging and drying and better keep the activity of the product.

Description

[0001] technical field [0002] The invention relates to a production and processing method of rabbit brain powder. Background technique [0003] Tissue factor is a membrane-bound lipid-dependent glycoprotein, which can form a complex with coagulation factor VII and significantly improve the activation ability of coagulation factor VII to factors X and IX. Tissue factor plays a hemostatic effect by activating the coagulation cascade reaction. Rabbit brain powder extracted with acetone is rich in tissue factor, so rabbit brain powder is widely used in medical clinical tests. [0004] At present, the production and processing of rabbit brain powder mostly adopts the method of crushing or homogenizing after removing blood vessels and meninges. Chinese patent No. 201110070215.7 discloses a processing method for industrial production of rabbit brain powder. In this method, blood vessels and meninges are removed from fresh rabbit brain, and then cold acetone is added to homogenat...

Claims

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Application Information

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IPC IPC(8): A61K35/30A61P7/04
Inventor 张运晴刘永需王晶孟庆福史敬义
Owner 青岛康大爱博生物科技有限公司
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