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A kind of production and processing method of rabbit brain powder

A processing method, the technology of rabbit brain powder, is applied in the direction of medical formula, extracellular fluid disease, unknown raw materials, etc., which can solve the problems of increased crushing cost, many impurities in blood vessels and meninges, and difficult separation process, so as to reduce centrifugation and drying Difficulty, effect of keeping alive

Active Publication Date: 2017-08-11
青岛康大爱博生物科技有限公司
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  • Summary
  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

Because the brain tissue is tightly combined with blood vessels and meninges, it is impossible to completely remove it by this method. Subsequent direct homogenization, crushing and drying will lead to increased crushing costs. Acetone forms a colloidal solution, which is difficult to separate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1 A kind of production processing method of rabbit brain powder, comprises the following steps:

[0012] 1. Soak the fresh rabbit brain in zero-degree acetone for about 10 minutes, and then use tweezers to remove the blood vessels and meninges in the rabbit brain;

[0013] 2. Put the rabbit brain from which the blood vessels and meninges have been removed into an extrusion device soaked in acetone. Control the volume of acetone to be twice the weight of the rabbit brain. meninges;

[0014] 3. Squeeze the rabbit brain into the grinder through the squeeze piston in the middle of the squeeze device, and the grinder grinds the rabbit brain for 10 minutes at a speed of 1 second / time;

[0015] 4. After grinding, start the filter screen at the bottom of the grinder to further filter out blood vessels and meningeal impurities, then add 20% acetone, shake gently for a few times and then centrifuge at 2000rpm / min for 3 minutes, remove the acetone solvent after centrif...

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Abstract

The invention relates to a production and processing method of rabbit brain powder. A production and processing method of rabbit brain powder, comprising the following steps: (1), soaking fresh rabbit brain in low-temperature acetone or saline to remove blood vessels and meninges; (2), removing the blood vessels and meninges of rabbit brains into Extrusion device soaked in acetone, squeeze the rabbit brain in the extrusion device into the grinder; (3), the grinder grinds the rabbit brain at a slow speed; (4), after grinding, start the filter at the bottom of the grinder , to further filter out blood vessels and meningeal impurities, then add acetone, shake a few times and then centrifuge, remove the acetone solvent after centrifugation, dry, subpackage, and store in a refrigerator at 4°C. The production and processing method of rabbit brain powder of the present invention further removes remaining more than 70% blood vessels and meningeal impurities through two steps of extruding and filtering; before grinding and centrifuging, add 20% acetone to reduce the colloidal state of the solution. It reduces the difficulty of subsequent centrifugation and drying while maintaining the activity of the product.

Description

technical field [0001] The invention relates to a production and processing method of rabbit brain powder. Background technique [0002] Tissue factor is a membrane-bound lipid-dependent glycoprotein, which can form a complex with coagulation factor VII and significantly improve the activation ability of coagulation factor VII to factors X and IX. Tissue factor plays a hemostatic effect by activating the coagulation cascade reaction. Rabbit brain powder extracted with acetone is rich in tissue factor, so rabbit brain powder is widely used in medical clinical tests. [0003] At present, the production and processing of rabbit brain powder mostly adopts the method of crushing or homogenizing after removing blood vessels and meninges. Chinese patent No. 201110070215.7 discloses a processing method for industrial production of rabbit brain powder. In this method, blood vessels and meninges are removed from fresh rabbit brain, and then cold acetone is added to homogenate, mixed ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/30A61P7/04
Inventor 张运晴刘永需王晶孟庆福史敬义
Owner 青岛康大爱博生物科技有限公司
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