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Antioxidant traditional Chinese medicine composition and preparation methods and application thereof

A composition and anti-oxidation technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of poor antioxidant function and low intake of antioxidant nutrients

Inactive Publication Date: 2014-07-09
TIANJIN TIANSHI BIOLOGICAL DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cai Meiqin and others conducted a nutritional survey on the elderly in Shanghai, and the results showed that the intake of antioxidant nutrients in middle-aged and elderly people is generally low, the serum superoxide dismutase (SOD) is low, and the serum lipid peroxide (LPO) is low. High, indicating that the body's antioxidant function is poor

Method used

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  • Antioxidant traditional Chinese medicine composition and preparation methods and application thereof
  • Antioxidant traditional Chinese medicine composition and preparation methods and application thereof
  • Antioxidant traditional Chinese medicine composition and preparation methods and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] (1) Extract the active ingredients of natto, grape seed and cassia seed:

[0076] Peel the soybeans, soak them in water for 18 hours, grind them, steam them, sterilize them at 120°C for 50 minutes, cool them naturally after sterilization, inoculate the sterilized soybeans with Bacteria natto, and ferment them for 16 hours at a temperature of 35°C and a humidity of 85%. hours, cooled to 5°C, dried, and pulverized to obtain natto powder;

[0077] Crush the grape seeds, extract twice with 40% ethanol at a temperature above 85°C, separate the macroporous resin, ethanol gradient elution, collect the eluate, concentrate at 50°C at 0.08MPa, recover the ethanol until the sugar content is 45°C, and dry it. Get grape seed extract.

[0078] Cassiae is crushed, extracted with 15 times the amount of 50% ethanol, and refluxed for 5 times, each time for 4 hours; the extract is filtered, separated by a polyamide 20-mesh column, eluted with ethanol, the eluate is collected, concentrate...

Embodiment 2

[0081] (1) Extract the active ingredients of natto, grape seed and cassia seed:

[0082] Peel the soybeans, soak them in water for 20 hours, grind them, steam them, sterilize them at 130°C for 50 minutes, cool them naturally after sterilization, inoculate the sterilized soybeans with Bacillus natto, ferment them for 16 hours at a temperature of 45°C and a humidity of 70%. hours, cooled to 10°C, dried, and pulverized to obtain natto powder;

[0083] Crush grape seeds, extract twice with 70% ethanol at a temperature above 85°C, separate with macroporous resin, ethanol gradient elution, collect the eluate, concentrate at 80°C at 0.08MPa, recover ethanol until the sugar content is 45°C, dry, Get grape seed extract.

[0084] Cassiae is crushed, extracted with 15 times the amount of 60% ethanol and refluxed for 3 times, each time for 4 hours; 0.08MPa), recover the ethanol until it has no alcohol smell, spray dry it, and sieve it through a 60-mesh sieve to obtain the cassia seed ex...

Embodiment 3

[0087] (1) Extract the active ingredients of natto, grape seed and cassia seed:

[0088] Peel the soybeans, soak them in water for 18 hours, grind them, cook them, sterilize them at 130°C for 50 minutes, cool them naturally after sterilization, inoculate the sterilized soybeans with Bacteria Natto, and ferment them for 24 hours at a temperature of 35°C and a humidity of 85%. hours, cooled to 10°C, dried, and pulverized to obtain natto powder;

[0089] Crush the grape seeds, extract twice with 40% ethanol at a temperature above 85°C, separate the macroporous resin, ethanol gradient elution, collect the eluate, concentrate at 60°C at 0.05MPa, recover the ethanol to a sugar content of 45°C, and dry it. Get grape seed extract.

[0090] Cassiae seeds are crushed, extracted with 10 times the amount of 60% ethanol, and refluxed for 5 times, each time for 2 hours; 0.08MPa), recover the ethanol until it has no alcohol smell, spray dry it, and sieve it through 80 meshes to obtain the ...

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Abstract

The invention discloses an antioxidant blood fat-reducing traditional Chinese medicine composition which comprises the following raw material drugs by weight: 20-60 parts of natto, 5-35 parts of grape seed and 5-20 parts of cassia seed. The antioxidant and blood fat-reducing traditional Chinese medicine composition is prepared by processing of the natural traditional Chinese medicine materials which are safe, less in side effects and low tendency to produce medicine resistance. The antioxidant blood fat-reducing traditional Chinese medicine composition can achieve the antioxidant and blood fat-reducing functions by reducing the level of peripheral blood triglyceride (TG), total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C), increaseing the level of high density lipoprotein cholesterol (HDL-C), clearing away free radicals, inhibiting oxidation of lipids, and the like.

Description

technical field [0001] The invention relates to an anti-oxidation and blood lipid-lowering traditional Chinese medicine composition and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] According to the data of the first China Aging Industry Summit Forum, the degree of aging in China is accelerating, and the elderly population is aging. Cai Meiqin and others conducted a nutritional survey on the elderly in Shanghai, and the results showed that the intake of antioxidant nutrients in middle-aged and elderly people is generally low, the serum superoxide dismutase (SOD) is low, and the serum lipid peroxide (LPO) is low. High, indicating that the body's antioxidant function is poor. Therefore, if exogenous antioxidants are supplemented in an appropriate amount for a long time, on the one hand, it can compensate the level of endogenous antioxidants (such as SOD); Oxygen free radicals can inhibit lipid peroxidatio...

Claims

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Application Information

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IPC IPC(8): A61K36/87A61P39/06A61P3/06
Inventor 柯学杨文文林丹丹
Owner TIANJIN TIANSHI BIOLOGICAL DEV
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