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Application of saikosaponin a in prevention and treatment of osteoporosis

A technology of saikosaponin and osteoporosis, which is applied in the direction of medical preparations containing active ingredients, bone diseases, organic active ingredients, etc., and can solve problems such as damage to cell structure and function

Inactive Publication Date: 2015-12-30
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, high concentrations of ROS can lead to oxidation reactions of nucleic acids, proteins, and lipids, damage the structure and function of cells, and cause diseases

Method used

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  • Application of saikosaponin a in prevention and treatment of osteoporosis
  • Application of saikosaponin a in prevention and treatment of osteoporosis
  • Application of saikosaponin a in prevention and treatment of osteoporosis

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Embodiment Construction

[0033] The present invention will be further described in detail below with reference to specific embodiments, which is an explanation but not a limitation of the present invention.

[0034] hBMSC is a human bone marrow mesenchymal stem cell with multi-directional differentiation potential, such as osteoblasts, adipocytes, fibroblasts, etc. It is a commonly used cell model for studying the growth and differentiation of bone marrow mesenchymal stem cells. H 2 O 2 Treatment is also a commonly used in vitro oxidative stress model. To observe the effect of saikosaponin a on the apoptosis and differentiation of human bone marrow mesenchymal stem cells and its anti-oxidative damage, hBMSC was selected as the cell model, H 2 O 2 The treatment is an in vitro oxidative stress model. As an animal model, the ovariectomized (castration) mouse model is a commonly used model to simulate postmenopausal osteoporosis in women.

[0035] 1. The protective effect of saikosaponin a on hBMSC apoptosis ca...

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Abstract

The invention discloses an application of saikoside a in prevention and treatment of osteoporosis. According to the application of saikoside a in the prevention and treatment of osteoporosis, saikoside a is characterized by being no toxic to human mesenchymal stem cells, not influencing cell proliferation, but preventing human mesenchymal stem cells from apoptosis caused by hydrogen peroxide, improving H2O2 induced oxidative stress state during differentiation, preventing human mesenchymal stem cells from differential inhibition caused by H2O2, inhibiting raising of adipogenic differentiation of human mesenchymal stem cells caused by H2O2, and also inhibiting the expression of bone resorption factors, so as to reduce apoptosis and differential inhibition of human mesenchymal stem cells and indirectly inhibit osteoclast activation to prevent osteoporosis. According to a castrated mice osteoporosis model, saikoside a can improve the oxidative stress of serum and can also improve cancellous bone microstructures of distal femur and the fourth lumbar vertebra; and therefore, saikoside a can be used for preparing a medicine for preventing and treating osteoporosis.

Description

Technical field [0001] The invention belongs to the technical field of prevention and treatment of osteoporosis, and relates to the application of saikosaponin a to prevention and treatment of osteoporosis. Background technique [0002] Osteoporosis (OP) is a systemic, degenerative, and metabolic bone disease caused by multiple causes of bone tissue bone loss, bone microstructure deterioration, and biomechanical performance decline, leading to increased bone fragility. Fractures are prone to occur, seriously threatening the physical and mental health of middle-aged and elderly people. [0003] Oxidative stress is a state in which high-active substances such as ROS (Reactiveoxygenspecies) are excessively produced in the body, which exceeds the body's scavenging ability, resulting in an imbalance between oxidation and anti-oxidation. ROS in the physiological range plays an important role in regulating normal human functions such as apoptosis, gene expression, signal transduction and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P19/10
Inventor 刘建黄强高博杨柳罗卓荆
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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