Intermediate V for anti-hepatitis C medicine Boceprevir as well as preparing method and application thereof

The technology of a compound and a compound of the general formula is applied in the field of preparation of the anti-hepatitis C drug Boceprevir, which can solve the problems of reaction detection and control of intermediates, side reactions and the like
CN103936628AInactive Publication Date: 2014-07-23SHANGHAI INST OF PHARMA IND +1
8 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI INST OF PHARMA IND
Publication Date
2014-07-23
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to the technical field of a preparing method of anti-hepatitis C medicine Boceprevir. A compound V (E) provided by the invention has a structural formula shown as the accompanying drawing. The operation of the compound preparation is simple and convenient, and the yield is higher. The compound can be used for synthesizing the anti-hepatitis C medicine Boceprevir, and a new thought and method can be provided for the synthesis of the anti-hepatitis C medicine Boceprevir. In addition, ultraviolet chromophoric groups are contained in molecules of the compound, the detection is more convenient than that of an ordinary synthesis method, and side reaction caused by oxhydryl nucleophilicity in a condensation step is avoided through the introduction of benzyls onto oxhydryls. Compared with the existing synthesis method, the preparing method provided by the invention has certain advantages.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the technical field of preparation methods for anti-hepatitis C drug Boceprevir. Background technique

[0002] Globally, the infection rate of hepatitis C virus (HCV) is about 3%, and the total number of infected people is about 200 million. Because of the high infection rate of HCV and the serious potential complications such as liver cirrhosis and liver cancer, HCV is a serious threat to human life and health. According to the Simmonds naming system, HCV can be divided into six main genotypes, namely I-VI, and each type can be divided into several subtypes (such as Ia, Ib, IIa, IIb, IIIa, IIIb, etc.). There are about 40 million HCV-infected people in my country, 69% of which are type I infections (mainly type Ib). The current treatment of chronic hepatitis C is mainly the combination of pegylated interferon (PEG-IFNα) and ribavirin (RBV), which fails to produce sustained virological response in about 50% of HCV type I patie...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More